Antitumor activity and toxicity of volatile oil from the leaves of Annona leptopetala

Brito, Monalisa Taveira; Ferreira, Rafael Carlos; Beltrão, Daiene Martins; Moura, Ana Paula Gomes e; Xavier, Aline Lira; Pita, João Carlos Lima Rodrigues; Batista, Tatianne Mota; Longato, Giovanna Barbarini; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de; Medeiros, Karina Carla de Paula; Santos, Sócrates Golzio dos; Costa, Vicente Carlos de Oliveira; Tavares, Josean Fechine; Diniz, Margareth de Fátima Formiga Melo; Sobral, Marianna Vieira

doi:10.1016/j.bjp.2018.06.009

Cited by 12 publications

(6 citation statements)

References 35 publications

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“…The antitumor activity and toxicity of the EO of Annona leptopetala leaves, which are rich in spathulenol (12.5%) and α-limonene (9.0%), were evaluated. The EO showed antitumor activity in vitro and in vivo, mainly in the leukemia cell line, without major changes seen in the toxicity parameters evaluated [42].…”

Section: Antiproliferative and Cytotoxic Activitiesmentioning

confidence: 89%

Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry, and Biological Activities

Cascaes

Carneiro

Nascimento

et al. 2021

IJMS

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The present work involves a systematic review of the chemical composition and biological effects of essential oils from the Annonaceae species collected in Brazil from 2011 to 2021. Annonaceae is one of the most important botanical families in Brazil, as some species have economic value in the market as local and international fruit. In addition, the species have useful applications in several areas—for instance, as raw materials for use in cosmetics and perfumery and as medicinal plants. In folk medicine, species such as Annona glabra L. and Xylopia sericea A. St.-Hil. are used to treat diseases such as rheumatism and malaria. The species of Annonaceae are an important source of essential oils and are rich in compounds belonging to the classes of mono and sesquiterpenes; of these compounds, α-pinene, β-pinene, limonene, (E)-caryophyllene, bicyclogermacrene, caryophyllene oxide, germacrene D, spathulenol, and β-elemene are the most abundant. The antimicrobial, anti-inflammatory, antileishmania, antioxidant, antiproliferative, cytotoxic, larvicidal, trypanocidal, and antimalarial activities of essential oils from the Annonaceae species in Brazil have been described in previous research, with the most studies on this topic being related to their antiproliferative or cytotoxic activities. In some studies, it was observed that the biological activity reported for these essential oils was superior to that of drugs available on the market, as is the case of the essential oil of the species Guatteria punctata (Aubl.) R. A. Howard., which showed a trypanocidal effect that was 34 times stronger than that of the reference drug benznidazol.

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Section: Antiproliferative and Cytotoxic Activitiesmentioning

confidence: 89%

Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry, and Biological Activities

Cascaes

Carneiro

Nascimento

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…Another report by Brito et al [ 34 ] noticeably discussed the antitumour and toxicity of volatile oil from Annona leptopetala leaf suggesting antitumour activity with moderate gastrointestinal toxicity. Our results corroborate these findings indicating antitumour activity without major changes in toxicity parameters evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…Another report by Brito et al [34] noticeably discussed the antitumour and toxicity of volatile Nonetheless, few investigators have reported that A. muricata induces cytotoxicity due to alteration in glucose metabolism resulting in unsafe metabolism obstructions. This impedance can be a target against cancer since the proliferating tumour cells have high energy demand provided by aerobic glycolysis and oxidative phosphorylation [32,37].…”

Section: Discussionmentioning

confidence: 99%

Antitumour activity of Annona muricata L. leaf methanol extracts against Ehrlich Ascites Carcinoma and Dalton’s Lymphoma Ascites mediated tumours in Swiss albino mice

Naik

Dessai

Krishnan

2020

Libyan Journal of Medicine

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The use of plants as a source of sedative or treatment for cancer is reasonably widespread worldwide. Annona muricata Linn exhibits a vast array of medicinal and ethno-pharmaceutical benefits, attributed by different plant parts. The activity of this plant is regarded to the bio-production of secondary metabolites like alkaloids, phenols, flavonoids, and most unique group of compounds, namely, annonaceous acetogenins. Whilst this plant is gaining popularity as an anticancer treating plant, this study was undertaken to verify the plausible anticancer effect of leaf methanol extracts of A. muricata (LEAM). Acute toxicity study was carried to obtain safe dose in mice models using haematological, biochemical, and histological evaluations in Swiss albino mice. In-vitro cytotoxicity towards Dalton's Lymphoma Ascites (DLA) and Ehrlich Ascites Carcinoma (EAC) cell lines were determined by trypan blue exclusion method. In-vivo antitumour activity of LEAM (100, 200, and 500mg/kg b.wt.) was evaluated using DLA induced solid carcinoma and EAC induced ascites carcinoma models and its comparison with standard drug Cisplatin. Acute toxicity studies did not exhibit significant variations in treated mice suggesting diminutive side effects of LEAM. Statistical analysis revealed the IC 50 values for DLA and EAC cell lines as 85.56 ± 5.28 and 68.07 ± 7.39 µg/mL, respectively, indicating better cytotoxic activity against EAC than DLA cells. LEAM decreased the tumour burden in dose-dependent manner. In comparison, with different concentrations tested, treatment with LEAM (200 mg/kg b.wt. and 500 mg/kg b.wt.) significantly reduced the solid tumour volume development by 58.11% and 65.70%, respectively. While lifespan was prolonged up to 51.43% in 500 mg/kg b.wt. LEAM treated ascites tumour-induced mice. This study thus indicates that LEAM possesses potent cytotoxic and antineoplastic activity and calls for more methodical safety assessments and other end-points of anti-tumourigenesis.

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“…The eremanthin extracted from Costus speciosus was found to stop the proliferation of MCF-7 and MDA-MB-231; it was found that eremanthin regulates cell growth by changing the expression of different signaling molecules [ 36 ]. Spathulenol is a tricyclic sesquiterpenoid compound with high anticancer activity [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Optimization of Supercritical Carbon Dioxide Extraction of Saussurea costus Oil and Its Antimicrobial, Antioxidant, and Anticancer Activities

et al. 2022

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Saussurea costus is a medicinal plant with different bioactive compounds that have an essential role in biomedicine applications, especially in Arab nations. However, traditional extraction methods for oils can lead to the loss of some volatile and non-volatile oils. Therefore, this study aimed to optimize the supercritical fluid extraction (SFE) of oils from S. costus at pressures (10, 20, and 48 MPa). The results were investigated by GC/MS analysis. MTT, DPPH, and agar diffusion methods assessed the extracted oils’ anticancer, antioxidant, and antimicrobial action. GC/MS results showed that elevated pressure from 10 to 20 and 48 MPa led to the loss of some valuable compounds. In addition, the best IC50 values were recorded at 10 MPa on HCT, MCF-7, and HepG-2 cells at about 0.44, 0.46, and 0.74 μg/mL, respectively. In contrast, at 20 MPa, the IC50 values were about 2.33, 6.59, and 19.0 μg/mL, respectively, on HCT, MCF-7, and HepG-2 cells, followed by 48 MPa, about 36.02, 59.5, and 96.9 μg/mL. The oil extract at a pressure of 10 MPa contained much more of á-elemene, dihydro-à-ionone, patchoulene, á-maaliene, à-selinene, (-)-spathulenol, cedran-diol, 8S,13, elemol, eremanthin, á-guaiene, eudesmol, ç-gurjunenepoxide-(2), iso-velleral, and propanedioic acid and had a higher antioxidant activity (IC50 14.4 μg/mL) more than the oil extract at 20 and 48 MPa. In addition, the inhibitory activity of all extracts was higher than gentamicin against all tested bacteria. One of the more significant findings from this study is low pressure in SFE enhancement, the extraction of oils from S. costus, for the first time. As a result, the SFE is regarded as a good extraction technique since it is both quick and ecologically friendly. Furthermore, SFE at 10 MPa increased the production and quality of oils, with high antioxidant activity and a positive effect on cancer cells and pathogens.

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Antitumor activity and toxicity of volatile oil from the leaves of Annona leptopetala

Cited by 12 publications

References 35 publications

Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry, and Biological Activities

Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry, and Biological Activities

Antitumour activity of Annona muricata L. leaf methanol extracts against Ehrlich Ascites Carcinoma and Dalton’s Lymphoma Ascites mediated tumours in Swiss albino mice

Optimization of Supercritical Carbon Dioxide Extraction of Saussurea costus Oil and Its Antimicrobial, Antioxidant, and Anticancer Activities

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