Chemical constituents from ethanol extract of Polyalthia rumphii branches and their cytotoxicity evaluation

Wang, Tianshan; Wu, Xiaoping; Liu, Yanping; Luo, You-Ping; Li, Xiang; Yujie, Zhou; Yang, Aiping; Yan, Zhengmeng; Ye, Ling; Chen, Siwei; Fu, Jinshuai; Jiao, Xianzhi

doi:10.1016/j.bjp.2018.03.004

Cited by 3 publications

(1 citation statement)

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“…For centuries, medicinal plants such as the Annonaceae species have been used in traditional medicines to cure various microbial diseases [ 9 ]. Polyalthia longifolia (false ashoka tree) is used in traditional medicine for the treatment of fever, skin diseases, diabetes, hypertension, and helminthiasis [ 10 ]. A literature survey revealed that aqueous and methanolic extracts of P. longifolia leaves also showed important antimicrobial properties [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

New Insights into the Antimicrobial Potential of Polyalthia longifolia—Antibiofilm Activity and Synergistic Effect in Combination with Penicillin against Staphylococcus aureus

et al. 2022

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Widespread antibiotic resistance has led to the urgent need for the identification of new antimicrobials. Plants are considered a valuable potential resource for new effective antimicrobial compounds. Therefore, in the present study, we focused on the antimicrobial activity of Polyalthia longifolia plants harvested from Cameroon using the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and time-kill assays. The mechanism of action was investigated by employing fluorescence and scanning electron microscopy. The anti-Staphylococcus aureus activity was studied using biofilm inhibition and checkerboard assays. Our results revealed that the tested extracts possess important antimicrobial activities, notably against Gram positive bacteria (MICs as low as 0.039 mg/mL). P. longifolia leaf extracts exhibited a significant bactericidal effect, with a total kill effect recorded after only 2 h of exposure at concentrations equivalent to MBC (0.078 and 0.156 mg/mL). The extracts showed a synergistic antibacterial activity in combination with penicillin against a MRSA clinical isolate and significantly inhibited S. aureus biofilm formation. The mechanism of action is related to the impairment of cell membrane integrity and cell lysis. All these findings suggest that P. longifolia could be an important source of reliable compounds used to develop new antimicrobials.

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