Iridoid and phenylethanoid glycosides from the aerial part of Barleria lupulina

Lee, Seoung Rak; Clardy, Jon; Senger, Donald R.; Cao, Shugeng; Kim, Ki‐Hyun

doi:10.1016/j.bjp.2016.01.002

Cited by 7 publications

(7 citation statements)

References 13 publications

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“…Studies have documented that B. lupulina has medicinal values, including anti-inflammation [ 12 ], antiviral [ 13 , 14 ], antibacterial [ 11 , 15 , 16 ], antidiabetic [ 17 ], cytotoxic [ 18 , 19 ], antidiuretic, and antiarthritic activity [ 20 , 21 ]. Several studies have also shown that the species possesses highly potential antioxidants and bioactive compounds used in treatments of various diseases and health issues [ 10 , 15 , 19 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Conditions for Microwave-Assisted Extraction of Polyphenolic Content and Antioxidant Activity of Barleria lupulina Lindl.

Ismail-Suhaimy

Gani

Zaidan

et al. 2021

Plants

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Barleria lupulina Lindl. (Acanthaceae) as an ornamental plant has been widely used in folklore medicine due to its abundancy in polyphenolic compounds. The present study examined conditions for optimal extraction of antioxidants from B. lupulina leaf extracts by using the microwave-assisted extraction (MAE) method. The effects of ethanol concentrations, microwave power, and extraction time on total phenolic content (TPC), total flavonoid content (TFC), 1-diphenyl-2-picrylhydrazyl (DPPH), and 2,20-azino-bis (3-ethylbenzothizoline-6-sulfonic acid) (ABTS) were investigated by single-factor experiments. Response surface methodology (RSM) was applied to observe interactions of three independent variables (ethanol concentrations, microwave power, and extraction time) on the dependent variables (TPC, TFC, DPPH, and ABTS) to establish optimal extraction conditions. Quadratic polynomial equations in all experimental models yielded favorably with fitted models with R2 and R2adj of more than 0.90 and a non-significant lack of fit at p > 0.05. The optimal conditions for the extraction of antioxidant activity were established at 80% (v/v) ethanol, 400 W, and 30 s with TPC (238.71 mg gallic acid equivalent (GAE)/g sample), TFC (58.09 mg QE/g sample), DPPH (87.95%), and ABTS (89.56%). Analysis by ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) successfully identified four new phenylethanoid glycoside compounds in the species.

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Section: Introductionmentioning

confidence: 99%

Optimizing Conditions for Microwave-Assisted Extraction of Polyphenolic Content and Antioxidant Activity of Barleria lupulina Lindl.

Ismail-Suhaimy

Gani

Zaidan

et al. 2021

Plants

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“…Phenylethanoid glycosides are a group of aqueous-soluble compounds, with majority of them have been isolated from medicinal plants [ 125 , 126 ]. The general structure of phenylethanoid glycosides has one glucopyranoside unit linked to the phenethyl alcohol.…”

Section: Phytochemical Evaluation Of Barleriamentioning

confidence: 99%

Phytochemicals and Biological Activities of Barleria (Acanthaceae)

Gangaram

Naidoo

Dewir

et al. 2021

Plants

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Plant species belonging to the family Acanthaceae are globally known to possess various medicinal properties and have cultural and economic importance in both traditional medicine and horticulture. They are important to both animals and humans and are used as food or for ornamental purposes worldwide. Barleria is the third largest genus in the family Acanthaceae. A few of the highly important and reported species of Barleria include B. prionitis, B. cristata, B. grandiflora, and B. lupulina. The flowers, leaves, stems, roots, and seed extracts of plants belonging to this genus are rich in bioactive compounds and have exhibited significant medicinal potential for the treatment of various ailments and infections. Evidence derived from several studies has demonstrated the antioxidant, antibacterial, antifungal, anti-inflammatory, anticancer, antidiabetic, antiulcer, hepatoprotective, analgesic, antiamoebic, antihelminthic, antiarthritic, antihypertensive, antiviral properties and toxicity of extracts, in addition inhibition of acetylcholinesterase activity and biosynthesis of nanoparticles, of the plant and seed extracts of species belonging to Barleria. Studies have reported that bioactive compounds such as flavonoids, quinones, iridoids, phenylethanoid glycosides, the immunostimulant protein “Sankaranin”, and antibiotics isolated from Barleria species are resposnsible for the above biological activities. Traditionally, the genus Barleria has significant medicinal potential; however, there is a scarcity of information on various species that are yet to be evaluated. This review provides a comprehensive report on existing literature, concerning the phytochemistry and biological activities of the genus Barleria.

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“…Another iridoid glycoside namely Barlupulin C methyl ester was isolated from aerial parts of B. lupulina. NMR data suggests that the molecular formula of the compound is C18H26O12 (19). Compounds like cyclobutane,1,1-dimethyl-2-octyl, 1-Hentetracontanol, 1,2-Benzenedicarboxylic acid, diisooctyl ester, 1-Hentetracontanol, 2-Hexyl-1-octanol were isolated from the essential oils of B. lupulina (20).…”

Section: Phytochemistry Of Barleria Speciesmentioning

confidence: 99%

Phytochemical, pharmacological and tissue culture studies of some important species of the genus Barleria L. (Acanthaceae) - a review

Sudheer

Nagella

2021

Plant Sci. Today

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Ayurvedic sciences helped the early humans to overcome chronic dangerous diseases. There are thousands of varieties of herbs and medicinal plants used to overcome such dreadful diseases. The genus Barleria L. belongs to family Acanthaceae, a medicinally significant group of plants having diversified phytochemicals used for different pharmacological properties. It has been utilized since ancient times for medicinal purposes. It has many plant secondary metabolites such as terpenes, flavonoids, lignins, alkaloids, particularly the iridoid glycosides. The secondary metabolites extracted from Barleria spp. show potential pharmacological activities viz., anti-microbial, anti-inflammatory, anti-oxidant, anti-fertility, anti-arthritic and anti-ulcer activity. In view of these, present review is focused on the phytochemistry, pharmacology and tissue culture studies of some of the important species of the genus Barleria L.

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Iridoid and phenylethanoid glycosides from the aerial part of Barleria lupulina

Cited by 7 publications

References 13 publications

Optimizing Conditions for Microwave-Assisted Extraction of Polyphenolic Content and Antioxidant Activity of Barleria lupulina Lindl.

Optimizing Conditions for Microwave-Assisted Extraction of Polyphenolic Content and Antioxidant Activity of Barleria lupulina Lindl.

Phytochemicals and Biological Activities of Barleria (Acanthaceae)

Phytochemical, pharmacological and tissue culture studies of some important species of the genus Barleria L. (Acanthaceae) - a review

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