The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo

Gao, Qing‐Han; Zhao, Xin; Yin, Lei; Zhang, Yuanbin; Wang, Bing; Wu, Xiuli; Zhang, Xinhui; Fu, Xueyan; Sun, Weihong

doi:10.1016/j.bjp.2016.01.001

Cited by 17 publications

(9 citation statements)

References 47 publications

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“…The enzymes SGOT and SGPT are important metabolic enzymes of the liver which normally exist in the cytoplasm but these enzymes enter into the circulatory system due to toxicity mediated altered permeability of the cellular membrane upon liver injury [27]. CCl 4 -induced elevation of ALP is in line with the high levels of serum bilirubin and the depletion of increased ALP with simultaneous suppression of raised bilirubin level indicates the stabilization of biliary dysfunction in the liver during the hepatic injury [4].…”

Section: Resultsmentioning

confidence: 75%

Hepatoprotective Activity of Aqueous Extract of Oxalis Debilis Kunth Against Ccl4 - Induced Liver Damage

Athokpam

Bawari

Choudhury

2017

Asian J Pharm Clin Res

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Objective: To evaluate the hepatoprotective activity of aqueous extract of Oxalis debilis Kunth in carbon tetrachloride (CCl 4 )-induced hepatotoxicity in Swiss albino mice.Methods: Hepatotoxicity was induced by CCl 4 30% in olive oil (1 ml/kg intraperitoneally). Mice were treated with aqueous extract of O. debilis at doses of 250 and 500 mg/kg body weight orally for 14 days. There were two groups, pre-treatment (once daily for 14 days before CCl 4 intoxication) and post-treatment (2, 6, 24, and 48 hrs after CCl 4 intoxication). The observed effects were compared with a known hepatoprotective agent, silymarin.Results: Pre-treatment and post-treatment groups of aqueous extract of O. debilis significantly reduced elevated serum levels of serum transaminases, alkaline phosphatase, and bilirubin and increased the level of total protein as compared to CCl 4 -treated group. The histopathological study also confirms the hepatoprotection. Preliminary qualitative phytochemical analysis of the plant revealed the presence of phenolic compounds, tannins, flavonoids, and saponins. Conclusion:The results of this study suggest that O. debilis can be used as safe, cheap, and alternative preventive and protective drugs against liver injury. The protective effect observed could be attributed to the presence of various phytochemicals which are responsible for the restoration of liver damage.

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Section: Resultsmentioning

confidence: 75%

Hepatoprotective Activity of Aqueous Extract of Oxalis Debilis Kunth Against Ccl4 - Induced Liver Damage

Athokpam

Bawari

Choudhury

2017

Asian J Pharm Clin Res

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“…The GC–MS and GC–FID analyses in Table 2 showed the presence of zingiberene (13.58%), α-curcumene (10.77%), β-sesquiphellandrene (9.86%), α-farnesene (5.30%), and β-bisabolene (5.93%) with sesquiterpene hydrocarbons in ginger; cinnamic aldehyde (13.06%) with the organic compounds of aldehyde in cinnamon, and finally, pulegone (5.61%) with monoterpenes extracted from spearmint. A review of the literature indicated that sesquiterpene hydrocarbons and monoterpenes could be effective in various biological activities such as antioxidant effects [41,42]. Zhan et al extracted α-zingiberene (22.29%), β-sesquiphellandrene (8.58%), α-farnesene (3.93%), β-bisabolene (3.87%), α-curcumene (2.63%) with sesquiterpene hydrocarbons from ginger volatile oil, which had antioxidant potency [43].…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to Be Pregnant: A Randomized Clinical Trial

et al. 2019

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This paper aimed to evaluate the effect of herbal mixture (Mentha spicata, Zingiber officinale, Cinnamomum zeylanicum, and Citrus sinensis) only and along with clomiphene citrate (CC) compared to CC on serum antioxidants, glycemic status, menstrual regulation, and rate of pregnancy. This single-blind randomized clinical trial was carried out on 60 infertile participants with polycystic ovary syndrome (PCOS) willing to be pregnant. They were randomly allocated into group 1 (n = 20) who received routine dose of CC pills (50–150 mg) for three menstrual cycles from the fifth day of menstruation for five days; group 2 (n = 20) who consumed herbal mixture daily (700 mg); and group 3 (n = 20) who used up herbal mixture along with CC for 3 months. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), fasting blood sugar (FBS), insulin, and homeostatic model assessment for insulin resistance (HOMA-IR) were measured in their blood samples. No statistically significant differences were observed between the three groups in terms of socio-demographic characteristics. After intervention, however, the levels of CAT in group 2 (adjusted mean difference (aMD): = 9.0; confidence interval (CI) 95% = 1.1–16.9) and group 3 (aMD = 12.2; CI 95% = 4.5–19.9), GPx in group 2 (aMD = 986.1; CI 95% = 141.1–1831.1) and group 3 (aMD = 1781.2; CI 95% = 960.7–2601.8), and SOD in group 2 (aMD = 55.1; CI 95% = 26.0–84.2) increased. While FBS in group 3 (aMD = −8.7; CI 95% = −14.7 to −2.7), insulin in group 2 (aMD = −5.6; CI 95% = −10.8 to −0.4), and HOMA-IR in group 2 (aMD = −1.3; CI 95% = −2.4 to −0.2) significantly decreased compared to the group 1. To summarize, herbal mixture supplements along with CC have beneficial effects on serum antioxidant levels, as well as glycemic biomarkers of infertile PCOS, menstrual regulation, and pregnancy rate.

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“…The pharmacological mechanisms of Yinzhihuang granules have not yet been completely understood due to its complex active ingredients and versatile action pathways. Modern pharmacological studies have found that the volatile oil component contained in the monarch drug Artemisiae Scopariae Herba can obviously antagonize the serum ALT and AST activities induced by carbon tetrachloride (CCl4) in mice with liver injury and can thus protect the liver from CCl4 injury [ 29 ]. By inducing the liver enzyme system, Artemisiae Scopariae Herba enhances the liver's absorption, binding, and excretion of bilirubin and promotes the removal of bilirubin [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Yinzhihuang Granules on Serum Liver Enzymes in Jaundice Patients: A Real-World Study Based on HIS Data

Zhang

Lyu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. Our aim was to analyze the influence of Yinzhihuang granules on serum liver enzymes in jaundice patients and to provide real-world evidence for the efficacy evaluation of Yinzhihuang granules in treating jaundice. Methods. We constructed a data warehouse which integrates real-world electronic medical records from the hospital information system of multiple 3A hospitals in China and used a descriptive statistical method to analyze the changes in the serum liver enzymes of the jaundice patients treated with Yinzhihuang granules and then used Wilcoxon signed-rank to test the changes in the indicators caused by the treatment. Results. After being treated with Yinzhihuang granules, the jaundice patients had a decrease in the average serum levels of total bilirubin, indirect bilirubin, aspartate aminotransferase, glutamyl transpeptidase, and alkaline phosphatase, and the differences were statistically significant ( P < 0.05 ) but had no significant changes in the average serum levels of direct bilirubin and alanine aminotransferase ( P > 0.05 ). Conclusion. The data analysis on the real-world electronic medical records demonstrate that Yinzhihuang granules help to reduce jaundice patients’ serum levels of total bilirubin, indirect bilirubin, aspartate aminotransferase, glutamyl transpeptidase, and alkaline phosphatase, but there is no evidence that Yinzhihuang granules help to reduce the jaundice patients’ serum levels of direct bilirubin and alanine aminotransferase.

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The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo

Cited by 17 publications

References 47 publications

Hepatoprotective Activity of Aqueous Extract of Oxalis Debilis Kunth Against Ccl4 - Induced Liver Damage

Hepatoprotective Activity of Aqueous Extract of Oxalis Debilis Kunth Against Ccl4 - Induced Liver Damage

The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to Be Pregnant: A Randomized Clinical Trial

Effects of Yinzhihuang Granules on Serum Liver Enzymes in Jaundice Patients: A Real-World Study Based on HIS Data

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