Screening of ferulic acid related compounds as inhibitors of xanthine oxidase and cyclooxygenase-2 with anti-inflammatory activity

Nile, Shivraj Hariram; Ko, Eun Young; Kim, Doo Hwan; Keum, Young‐Soo

doi:10.1016/j.bjp.2015.08.013

Cited by 102 publications

(58 citation statements)

References 24 publications

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“…Polyphenols like caffeic acid, ferulic acid, sinapic acid, quercetin and kaempferol, highly present in the current samples, have been reported as having strong antioxidant, anti-inflammatory and antimicrobial activities (Marchese et al, 2014;Deng et al, 2015;Harwansh et al, 2015). These compounds in different in vitro and in vivo bioassays, showed an intense antioxidant potential and anti-inflammatory activity against ROS through the regulation of different cellular enzymatic mechanisms (Crespo et al, 2008;De Melo et al, 2009;Wang & Wang, 2015;Ferlemi et al, 2016;Nile et al, 2016). Similar conclusions were taken about the role of ferulic acid, quercetin and kaempferol.…”

Section: Figuresupporting

confidence: 70%

“…Similar conclusions were taken about the role of ferulic acid, quercetin and kaempferol. These compounds in different in vitro and in vivo bioassays, showed an intense antioxidant potential and anti-inflammatory activity against ROS through the regulation of different cellular enzymatic mechanisms (Crespo et al, 2008;De Melo et al, 2009;Wang & Wang, 2015;Ferlemi et al, 2016;Nile et al, 2016). Thus, the presence of such compounds in the three studied wastes, reinforce their interest to be used for the extraction of important bioactive compounds.…”

Section: Resultsmentioning

confidence: 82%

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Reuse potential of vegetable wastes (broccoli, green bean and tomato) for the recovery of antioxidant phenolic acids and flavonoids

Aires

Carvalho

Saavedra

2016

Int J of Food Sci Tech

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Summary The aim of this study was to evaluate the potential use of crop wastes (stems and leaves) from broccoli, beans and tomato to extract antioxidant polyphenols. Two different methods of extraction were performed: ultrasound (40 kHz) and conventional with 70 °C. In both methods, alkaline and acidic solvents were used. The polyphenol composition was assessed by HPLC‐DAD/UV‐VIS, and the 2,2‐diphenyl‐1‐picrylhydrazyl assay was used to measure the antioxidant activity. The results showed a significant variation of polyphenol composition and antioxidant activity with the type of sample, pH of solvent and extraction method. Also it was possible to observe that acidic methanol and 70 °C enables the extraction of significant amounts of phenolic acids and flavonoids. Based in our results, broccoli, green bean and tomato wastes can be used to extract antioxidant polyphenols, and the use of such wastes to extract polyphenols can be an opportunity to develop an environmental friendly management's systems creating incoming for producers and agro‐food sector.

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Section: Figuresupporting

confidence: 70%

Section: Resultsmentioning

confidence: 82%

Reuse potential of vegetable wastes (broccoli, green bean and tomato) for the recovery of antioxidant phenolic acids and flavonoids

Aires

Carvalho

Saavedra

2016

Int J of Food Sci Tech

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“…Literature data report high efficacy of ferulic acid and its derivatives in reducing xanthine oxidase and cyclooxygenase activity. It is therefore believed that ferulic acid reduces the amount of ROS produced by the enzyme-catalyzed transformation [17].…”

Section: Antioxidative Activity Of Ferulic Acidmentioning

confidence: 99%

Antioxidant Properties of Ferulic Acid and Its Possible Application

Zduńska¹,

Dana²,

Kołodziejczak³

et al. 2018

Skin Pharmacol Physiol

497

251

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Ferulic acid has low toxicity and possesses many physiological functions (anti-inflammatory, antioxidant, antimicrobial activity, anticancer, and antidiabetic effect). It has been widely used in the pharmaceutical, food, and cosmetics industry. Ferulic acid is a free radical scavenger, but also an inhibitor of enzymes that catalyze free radical generation and an enhancer of scavenger enzyme activity. Ferulic acid has a protective role for the main skin structures: keratinocytes, fibroblasts, collagen, elastin. It inhibits melanogenesis, enhances angiogenesis, and accelerates wound healing. It is widely applied in skin care formulations as a photoprotective agent, delayer of skin photoaging processes, and brightening component. Nonetheless, its use is limited by its tendency to be rapidly oxidized.

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“…The inhibition or decrease in growth level by these factors may be useful in control on management of variety of inflammatory conditions. [5,33] …”

Section: Cytotoxicitymentioning

confidence: 99%

“…[3,4] The utilization of flavonoids like ferulic acid and gallic acid, and their related compounds proved to having significant xanthine oxidase (XO) and cyclooxygenase activity. [5] Many dietary flavonoids such as pinobanksin, galangin, pinocembrin, pinocembrin-7-O--D-glucopyranoside, and glabranin were also having XO inhibitory activity. Enzyme kinetic studies and molecular docking simulation showed the mechanisms underlying for the XO inhibitory activities.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, anti‐inflammatory, and enzyme inhibitory activity of natural plant flavonoids and their synthesized derivatives

Nile

Keum

Nile

et al. 2017

J Biochem & Molecular Tox

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The synthesized flavonoid derivatives were examined for their antioxidant, anti-inflammatory, xanthine oxidase (XO), urease inhibitory activity, and cytotoxicity. Except few, all the flavonoids under this study showed significant antioxidant activity (45.6%-85.5%, 32.6%-70.6%, and 24.9%-65.5% inhibition by DPPH, ferric reducing/antioxidant power, and oxygen radical absorption capacity assays) with promising TNF-inhibitory activity (42%-73% at 10 M) and IL-6 inhibitory activity (54%-81% at 10 M) compared with that of control dexamethasone. The flavonoidsO 7 -hexyl chrysin, showed an inhibition with IC 50 values (4.5-8.1 g/mL), more than allopurinol (8.5 g/mL) at 5 M against XO and showing more than 50% inhibition at a final concentration (5 mM) with an IC 50 value of ranging from 4.8 to 7.2 ( g/mL) in comparison with the positive control thiourea (5.8 g/mL) for urease inhibition. Thus, the flavonoid derivatives may be considered as potential antioxidant and antigout agents.

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Screening of ferulic acid related compounds as inhibitors of xanthine oxidase and cyclooxygenase-2 with anti-inflammatory activity

Cited by 102 publications

References 24 publications

Reuse potential of vegetable wastes (broccoli, green bean and tomato) for the recovery of antioxidant phenolic acids and flavonoids

Reuse potential of vegetable wastes (broccoli, green bean and tomato) for the recovery of antioxidant phenolic acids and flavonoids

Antioxidant Properties of Ferulic Acid and Its Possible Application

Antioxidant, anti‐inflammatory, and enzyme inhibitory activity of natural plant flavonoids and their synthesized derivatives

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