Characterization and evaluation of the cytotoxic potential of the essential oil of Chenopodium ambrosioides

Degenhardt, Ruth T.; Farias, Ingrid Vicente; Grassi, Liliane Trivellato; Franchi, Gilberto C.; Nowill, Alexandre E.; Bittencourt, Christiane Meyre da Silva; Wagner, Theodoro Marcel; Souza, Márcia María de; Cruz, Alexandre Bella; Malheiros, Ângela

doi:10.1016/j.bjp.2015.08.012

Cited by 42 publications

(21 citation statements)

References 20 publications

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“…The leaves of C. ambrosioides especially have been broadly studied, but the results vary strongly. While some authors find ascaridole and derivates with about 50–80.0% as the main component [ 33 , 49 – 51 ], others find it with less than 10% as a minor component [ 52 , 53 ]. It is supposed that, apart from the different geographic location, the part of the plant, or the processing method, those differences can be explained by the existence of different varieties of the plant: C. ambrosioides var.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, the whole aerial part is not considered (very) cytotoxic: Ruffa et al (2002) did not detect cytotoxic effects up to 1,000 μ g/ml for HepG2 [ 57 ], Koba et al (2009) found a CC 50 = 700 μ g/ml for HaCaT [ 50 ], and Barros et al (2013) determined CC 50 of 264 to 319 μ g/ml for HeLa, HepG2, and HCT-15 [ 58 ]; those values are in the range of CC 50 = 563 ± 66 μ g/ml ELM that we report for Caco-2. Although Degenhardt et al (2016) reported cytotoxic effects of an ethanolic leaf extract against blood cell lines with CC 50 of 30–62 μ g/ml [ 33 ] and Al-kaf et al (2016) reported a CC 50 ≈ 25 μ g/ml for HT-29 for a hydrodistillate [ 51 ], both associated the cytotoxic effect to the high ascaridole content of their extracts, which coincide with a report on the cytotoxicity of ascaridoles with CC 50 = 4.2–23.7 μ g/ml for different tumour cell lines [ 59 ]. However, Koba et al (2009) could demonstrate that it is neither ascaridole (CC 50 > 1 mg/ml), as suspected, nor p -cymene (CC 50 > 1 mg/ml), but neral (CC 50 ≈ 100 μ g/ml) is the cytotoxic principle [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

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In Vitro Bioactivity of Methanolic Extracts from Amphipterygium adstringens (Schltdl.) Schiede ex Standl., Chenopodium ambrosioides L., Cirsium mexicanum DC., Eryngium carlinae F. Delaroche, and Pithecellobium dulce (Roxb.) Benth. Used in Traditional Medicine in Mexico

Knauth

Acevedo-Hernández

Cano

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Seven out of eight methanolic extracts from five plants native to Mexico were inactive against ten bacterial strains of clinical interest. The fruit extract of Chenopodium ambrosioides inhibited the bacteria Enterococcus faecalis (MIC = 4375 μg/ml), Escherichia coli (MIC = 1094 μg/ml), and Salmonella typhimurium (MIC = 137 μg/ml). The fruit extract of C. ambrosioides was with CC50 = 45 μg/ml most cytotoxic against the cell-line Caco-2, followed by the leaf extract from Pithecellobium dulce (CC50 = 126 μg/ml); interestingly, leaves of C. ambrosioides (CC50 = 563 μg/ml) and bark of P. dulce (CC50 = 347 μg/ml) extracts were much less cytotoxic. We describe for the first time the cytotoxic effect from extracts of the aerial parts and the flowers of Cirsium mexicanum (CC50 = 323 μg/ml and CC50 = 250 μg/ml, resp.). Phytochemical analysis demonstrated for both extracts high tannin and saponin and low flavonoid content, while terpenoids were found in the flowers. For the first time we report a cytotoxicological study on an extract of Eryngium carlinae (CC50 = 356 μg/ml) and likewise the bark extract from Amphipterygium adstringens (CC50 = 342 μg/ml). In conclusion the fruit extract of C. ambrosioides is a potential candidate for further biological studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In Vitro Bioactivity of Methanolic Extracts from Amphipterygium adstringens (Schltdl.) Schiede ex Standl., Chenopodium ambrosioides L., Cirsium mexicanum DC., Eryngium carlinae F. Delaroche, and Pithecellobium dulce (Roxb.) Benth. Used in Traditional Medicine in Mexico

Knauth

Acevedo-Hernández

Cano

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…The methyl petroselinate has antioxidant activity [55]. Ascaridol, a bicyclic monoterpenoid showed cytotoxicity against MDA MB-231 breast cancer [56]. The presence of these bioactive compounds in the crude extract of Curvularia papendorfii can justify its interesting biological activities as antiviral, antibacterial and antiproliferative properties.…”

Section: Biological Activities Of Identified Compounds and Kheiric Acidmentioning

confidence: 99%

Evaluation of Antiviral, Antibacterial and Antiproliferative Activities of the Endophytic Fungus Curvularia papendorfii, and Isolation of a New Polyhydroxyacid

et al. 2020

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An endophytic fungus isolated from Vernonia amygdalina, a medicinal plant from Sudan, was taxonomically characterized as Curvularia papendorfii. Ethyl acetate crude extract of C. papendorfii revealed an important antiviral effect against two viral pathogens, the human coronavirus HCoV 229E and a norovirus surrogate, the feline coronavirus FCV F9. For the last one, 40% of the reduction of the virus-induced cytopathogenic effect at lower multiplicity of infection (MOI) 0.0001 was observed. Selective antibacterial activity was obtained against Staphylococcus sp. (312 µg/mL), and interesting antiproliferative activity with half maximal inhibitory concentration (IC50) value of 21.5 ± 5.9 µg/mL was observed against human breast carcinoma MCF7 cell line. Therefore, C. papendorfii crude extract was further investigated and fractionated. Twenty-two metabolites were identified by gas chromatography coupled to mass spectrometry (GC–MS), and two pure compounds, mannitol and a new polyhydroxyacid, called kheiric acid, were characterized. A combination of spectroscopic methods was used to elucidate the structure of the new aliphatic carboxylic acid: kheiric acid (3,7,11,15-tetrahydroxy-18-hydroxymethyl-14,16,20,22,24-pentamethyl-hexacosa-4E,8E,12E,16,18-pentaenoic acid). Kheiric acid showed an interesting result with a minimum inhibitory concentration (MIC) value of 62.5 µg/mL against meticillin-resistant Staphylococcus aureus (MRSA). Hence, endophytes associated with medicinal plants from Sudan merit more attention, as they could be a treasure of new bioactive compounds.

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“…Earlier reports had shown that the extracts and essential oil of C. ambrosioides and its fractions showed cytotoxic potential ( Nowak et al., 2016 ; Degenhardt et al., 2016 ). Another report on the toxicity of aqueous extract of Chenopodium ambrosioides leaves, showed that no animals from either acute or sub chronic trial exhibited any signs of toxicity; however, slight hepatotoxic lesions in the rats were produced ( da Silva et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Design, formulation and evaluation of Chasmanthera dependens Hochst and Chenopodium ambrosioides Linn based gel for its analgesic and anti-inflammatory activities

Kola-Mustapha

Yohanna

Ghazali

et al. 2020

Heliyon

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Background The incidence of pain and inflammation in West Africa and in fact globally, continues to increase at an alarming rate. This research was conducted to investigate the analgesic and anti-inflammatory activities of leaf extracts of Chasmanthera dependens and Chenopodium ambrosioides ; formulate and evaluate polyherbal gels from their combination in a bid to providing topical therapeutic solutions to pain and inflammation. Methods Pre-formulation studies (phytochemical analysis, in vitro analgesic and anti-inflammatory activities) were conducted on the methanol leaf extracts of Chasmanthera dependens and Chenopodium ambrosioides . Individual and polyherbal gels were prepared using polymer carbopol 940 (1%) at combination ratios of 0:100, 25:75, 50:50, 75:25 and 100:0 Chasmanthera : Chenopodium. These herbal gels were evaluated for physical parameters, pH, viscosity, extrudability and spreadability. Analgesic and anti-inflammatory activities of herbal gels were evaluated by their inhibitory activities (percentage inhibition) against COX-2, TNF-α, IL-10, PGE-2 and compared with commercial diclofenac gel. Results The phytochemicals of the two extracts detected gave varied contents of major classes of secondary metabolites. The pre formulation inhibitory studies of the two extracts exhibited dose dependent inhibitory activities against COX-2, TNF-α, IL-10, PGE-2. The physical appearance, homogeneity, and consistency of the herbal formulations were good. The herbal gels were spreadable with good extrudability. The pH of the herbal gels ranged from 4.5 ± 0.4 to 5.2 ± 0.4. The viscosity of the herbal gels ranged between 4.3 ± 0.2 and 4.7 ± 0.4 Pas. The herbal gels exhibited significant differences in inhibitory activities against COX-2, TNF-α, IL-10, PGE-2 when compared with control commercial diclofenac gel. Conclusion The outcomes, including the inhibition of mediators COX-2, TNF-α, IL-10, PGE-2, confirm the use of the plant extracts under study, the individual and polyherbal gels formulated for the potential topical therapeutic treatment of pain and inflammation.

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Characterization and evaluation of the cytotoxic potential of the essential oil of Chenopodium ambrosioides

Cited by 42 publications

References 20 publications

In Vitro Bioactivity of Methanolic Extracts from Amphipterygium adstringens (Schltdl.) Schiede ex Standl., Chenopodium ambrosioides L., Cirsium mexicanum DC., Eryngium carlinae F. Delaroche, and Pithecellobium dulce (Roxb.) Benth. Used in Traditional Medicine in Mexico

In Vitro Bioactivity of Methanolic Extracts from Amphipterygium adstringens (Schltdl.) Schiede ex Standl., Chenopodium ambrosioides L., Cirsium mexicanum DC., Eryngium carlinae F. Delaroche, and Pithecellobium dulce (Roxb.) Benth. Used in Traditional Medicine in Mexico

Evaluation of Antiviral, Antibacterial and Antiproliferative Activities of the Endophytic Fungus Curvularia papendorfii, and Isolation of a New Polyhydroxyacid

Design, formulation and evaluation of Chasmanthera dependens Hochst and Chenopodium ambrosioides Linn based gel for its analgesic and anti-inflammatory activities

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