Rapid validated high performance thin layer chromatography method for simultaneous estimation of mangiferin and scopoletin in Canscora decussata (South Indian Shankhpushpi) extract

Sethiya, Neeraj Kumar; Trivedi, Ashish; Mishra, S.H.

doi:10.1016/j.bjp.2015.04.002

Cited by 22 publications

(9 citation statements)

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“…HPTLC studies revealed the presence of various phytochemicals shown in Table 1, as reported and published in our earlier studies and may be utilized for phytochemical differentiation among four varieties of Shankhpushpi [9], [15], [16], [17].…”

Section: Resultsmentioning

confidence: 59%

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Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India

Sethiya

Nahata

Singh

et al. 2019

Journal of Ayurveda and Integrative Medicine

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Section: Resultsmentioning

confidence: 59%

“…High Performance Thin Layer Chromatography (HPTLC) studies were performed using various solvent systems as reported in our earlier studies [9], [15], [16], [17].…”

Section: Methodsmentioning

confidence: 99%

Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India

Sethiya

Nahata

Singh

et al. 2019

Journal of Ayurveda and Integrative Medicine

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“…Source of Scopoletin: Scopoletin (7-hydroxy-6methoxy coumarin) is a phenolic coumarin isolated from various parts of the plant (roots, fruits, leaves, stems, etc.) such as Acer saccharum Marsh 45 , Aegle marmelos 30 , Aleurites moluccana (L.) 46 , Arabidopsis thaliana 47 , Artemisia annua 48 , Artemisia feddei 49 , Artemisia iwayomogi 50 , Brunfelsia hopeana 51 , Canscora decussate 52 , Chenopodium murale 53 , Cirsium setidens 54 , Clausena excavate Burm.f. (Pyin-daw-thein) 55 , Convolvulus prostrates 56 , Erycibe obtusifolia Benth 9 , Fagraea ceilanica 57 , Gossypium hirsutum 58 , Hevea brasiliensis 59 , Hedyotis capitellata 60 , Helianthus anuus 61 , Helichrysum italicum 62 , Hymenodictyon floribundum 63 , Hymenodictyon obovatum 64 , Hypochaeris radicata 65 , Ipomoea batatas 66 , Ipomoea digitata 67 , Ipomoea reniformis 68 , Lasianthus lucidus Blume1, Macaranga gigantifolia Merr 69 , Magnolia fargesii 70 , Manihot esculenta 71 , Melia azedarach L. 20 , Morinda citrifolia 12 , Morus alba L. (Po-sa) 72 , Nicotiana tabacum 73 , Scaphopetalum thonneri 74 , Sinomonium acutum 29 , Solanum lyratum 39 , Tetrapleura tetraptera 75 , Tilia cordata Mill 76 , Ulmus pumila, Ulmus campestris 77 , Viburnum tinus 7...…”

Section: Fig 1: Chemical Structure Of Scopoletinmentioning

confidence: 99%

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2021

IJPSR

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Scopoletin (7-hydroxy-6-methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. This article is created to provide information regarding the synthesis and pharmacological activity of scopoletin. Scopoletin has been found in many plant species and isolated from various parts of the plant (roots, fruits, leaves, stems, etc.) such as Morinda citrifolia, Aegle marmelos, Erycibe obtusifolia Benth, Lasianthus lucidus Blume, Melia azedarach L., Sinomonium acutum, Convolvulus prostratus, and Solanum lyratum, etc. which all possess a number of medicinal properties. Its various pharmacological activities have been reported through a number of investigations. It is reported that such compounds produced specific biological activities and possible health implications for humans in food and medicine. Pharmacological activities that are established in-vivo are antithyroid, antihypertensive, anti-proliferative, anti-inflammatory, neurological, anti-dopaminergic and anti-adrenergic, antidiabetic drug, and antihyperuricemic activities. Based on in-vitro studies, scopoletin has pharmacological activities, including an antihepatotoxicity, antibacterial, antifungal, antitubercular, and antioxidant. From the assorted pharmacological activities of scopoletin, it has the potential to be further developed.INTRODUCTION: Scopoletin (7-hydroxy-6methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. It has a yellow crystalline structure with a molecular weight of 192 and a melting point of 204-206 °C. Its various biological activities have been reported through a number of investigations. Booth et al., (2004) reported that such compounds produced specific biological activities and possible health implications for humans in food and medicine.

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“…Quantitative analysis of mangiferin by high-performance thin-layer chromatography (HPTLC). HPTLC analysis was determined according to the method of Sethiya et al (2015). The chromatogram was performed on 20 x 10 cm aluminum plate coated with silica gel 60 F254.…”

Section: Phytochemical Analysismentioning

confidence: 99%

Comparison of Antioxidant and α-Glucosidase Inhibitory Activities in Different Cultivars of Five Mango (Mangifera Indica L.) Leaf Extracts

Chewchinda¹,

Suriyaphan²,

Kanchanadumkerng³

et al. 2020

CMUJNS

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The objectives of study were to evaluate and compare the antioxidant, total phenolic, total flavonoid, mangiferin content and antidiabetic activities of five young mango cultivars leaf extract, namely, ‘Apple’, ‘Nam Dok Mai’, ‘Bao’, ‘OkRong’ and ‘Kiew Savoey’. Antioxidant effect was investigated by DPPH, ABTS radical scavenging activity, and ferric reducing power (FRAP) assays. Inhibitory on α-glucosidase activity and type of enzyme inhibition were evaluated by using Lineweaver Burk plot analysis. Mangiferin, major active compound, was quantified by HPTLC method. Furthermore, the hypoglycemic effect was determined using streptozotocin (STZ) –nicotinamide (NA) -induced type 2 diabetic mice. Young mango cv. ‘Apple’ leaf extract demonstrated the strongest antioxidant activity in all assays. Moreover, it contains highest amounts of total phenolic and mangiferin to the values of 311 mg GAE/g extract and 197 mg/g extract, respectively. It possessed potent α-glucosidase inhibitory activity with IC50 value of 0.50 µg/mL. Lineweaver-Burk plot analysis demonstrated a non-competitive inhibition of αglucosidase activity with the inhibition constant (Ki) of 2.98 µg/mL. Coadministration of young mango cv. ‘Apple’ leaf extract at dose of 1,000 mg/kg significantly reduced the total blood glucose level by 13.43% in STZ-NA-induced type 2 diabetic mice when compared with control diabetic mice in oral glucose tolerance test (OGTT) model. Inhibition of glucose absorption may be one of the possible mechanism of its hypoglycemic effect. In conclusion, young mango cv. ‘Apple’ leaf extract possesses the strongest antioxidant and antidiabetic activities which has a potential to develop as nutraceutical products.

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Rapid validated high performance thin layer chromatography method for simultaneous estimation of mangiferin and scopoletin in Canscora decussata (South Indian Shankhpushpi) extract

Cited by 22 publications

References 29 publications

Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India

Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India

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Comparison of Antioxidant and α-Glucosidase Inhibitory Activities in Different Cultivars of Five Mango (Mangifera Indica L.) Leaf Extracts

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