Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats

Paixão, Mônica Silveira; Melo, Mônica Santos de Souza; Damascena, Nicole Prata; Araújo, Adriano A. S.; Soares, Andrea Ferreira; Oliveira, Denise V.A.; Oliveira, Jeison Saturnino de; Almeida, Francisco A. G.; Amaral, Francilene S.; Araujo, Brancilene Santos de; Estevam, Charles S.; Botelho, Marco Antônio; Quintans‐Júnior, Lucindo José

doi:10.1016/j.bjp.2014.12.002

Cited by 13 publications

(10 citation statements)

References 30 publications

(46 reference statements)

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“…Also, the plant has cytotoxicity and insecticide properties [ 223 ]. H. pectinata has an important neurogenic and inflammatory orofacial antinociceptive effects, without interference in the motor performance.…”

Section: Species Of the Lamiaceae Family With Potential Analgesic/mentioning

confidence: 99%

“…The opioid system seems unlikely to participate in the antinociception caused by the extract [ 224 ]. The local application of dental gel based on H. pectinata has anti-inflammatory effect and also prevents alveolar bone resorption and weight loss in animals with periodontitis [ 223 ]. The healing effect of H. pectinata suggests that this plant may have antileishmanial action [ 219 ].…”

Section: Species Of the Lamiaceae Family With Potential Analgesic/mentioning

confidence: 99%

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Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

246

143

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Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a reliable source of new therapy. Pain is a global public health problem with a high impact on life quality and a huge economic implication, becoming one of the most important enemies in modern medicine. The medicinal use of plants as analgesic or antinociceptive drugs in traditional therapy is estimated to be about 80% of the world population. The Lamiaceae family, one of the most important herbal families, incorporates a wide variety of plants with biological and medical applications. In this study, the analgesic activity, possible active compounds of Lamiaceae genus, and also the possible mechanism of actions of these plants are presented. The data highlighted in this review paper provide valuable scientific information for the specific implications of Lamiaceae plants in pain modulation that might be used for isolation of potentially active compounds from some of these medicinal plants in future and formulation of commercial therapeutic agents.

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Section: Species Of the Lamiaceae Family With Potential Analgesic/mentioning

confidence: 99%

Section: Species Of the Lamiaceae Family With Potential Analgesic/mentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

246

143

View full text Add to dashboard Cite

show abstract

“…It has been alleged that the Hyptis genus possesses medicinal properties and it is recommended in folk medicine for the treatment of several conditions, such as gastrointestinal disorders, skin infections, nasal congestion, fever and cramps (Rojas et al, 1992[ 43 ]). Additionally, redox, analgesic and anti-inflammatory profiles have been reported to this genus (Franco et al, 2011[ 12 ]; Lima et al, 2013[ 25 ]; Menezes et al, 2015[ 31 ]; Paixão et al, 2015[ 35 ], 2013[ 36 ]).…”

Section: Introductionmentioning

confidence: 99%

HPLC-DAD analysis, antinociceptive and anti-inflammatory properties of the ethanolic extract of Hyptis umbrosa in mice

Anjos

Araújo-Filho

Duarte

et al. 2017

EXCLI Journal; 16:Doc14; ISSN 1611-2156

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“…Natural compounds have been used for different therapeutic applications, including antinociceptive (Almeida et al, 2015;Bonjardim et al, 2011;Franco et al, 2011;Melo et al, 2014), antioxidant (Paixão et al, 2013), and antiinflammatory (Veras et al, 2013;Paixão et al, 2015) activities. However, there are few studies that describe pharmacological effects of a nanostructured gel of thymol in acute periodontitis model.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

et al. 2015

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Lippia sidoides Cham (Verbenaceae) is largely distributed in the northeastern region of Brazil. It is popularly known as 'Alecrim-pimenta'. Recent studies have shown that some species of Lippia have interesting pharmacological activities. This study aimed to evaluate the effect of a nanostructured thymol gel (TG) 1.2 mg/g on acute phase of ligature-induced periodontitis model [acute periodontal disease (APD)] in rats. APD was induced in 24 Wistar rats subjected to ligature placement on left molars in maxillae. Animals were treated with TG, immediately after APD induction. Saline-based gel was utilized as negative control and diethylammonium diclofenac gel 10 mg/g was used as positive control. Animals were randomly assigned into the groups. The periodontium and the surrounding gingiva were examined at histopathology, as well as the neutrophil influx into the gingiva was assayed using myeloperoxidase activity levels by ELISA method. TG treatment reduced tissue lesion at histopathology coupled to decreased myeloperoxidase activity production in gingival tissue when compared with the saline gel control group (p < 0.05). The TG gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue confirming to be effective in reducing gingival inflammation in this model.

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Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats

Cited by 13 publications

References 30 publications

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

HPLC-DAD analysis, antinociceptive and anti-inflammatory properties of the ethanolic extract of Hyptis umbrosa in mice

Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

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