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citations
Cited by 12 publications
(9 citation statements)
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References 18 publications
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“…Therefore, a possible mechanism underlying the protective effect of CMO and CA against the genotoxicity induced by MMS is their ability to diminish alkylating DNA damage. As reported by Gonçalves et al (2014) and Silva et al (2017), the major compounds detected in CMO oleoresin are sesquiterpenes β-caryophyllene and αcopaene, as well as the diterpenes CA and (−)-3-βacetoxy copalic acids, respectively. It is important to indicate that Copaifera oleoresin are composed of volatile and non-volatile fractions, predominantly containing sesquiterpenes and acid diterpenes, respectively.…”
Section: Discussionsupporting
confidence: 54%
“…Therefore, a possible mechanism underlying the protective effect of CMO and CA against the genotoxicity induced by MMS is their ability to diminish alkylating DNA damage. As reported by Gonçalves et al (2014) and Silva et al (2017), the major compounds detected in CMO oleoresin are sesquiterpenes β-caryophyllene and αcopaene, as well as the diterpenes CA and (−)-3-βacetoxy copalic acids, respectively. It is important to indicate that Copaifera oleoresin are composed of volatile and non-volatile fractions, predominantly containing sesquiterpenes and acid diterpenes, respectively.…”
Section: Discussionsupporting
confidence: 54%
“…The copaiba oil has not yet been registered as a phytochemical drug. Thus, in the present study, toxicogenetic assays were necessary to verify possible deleterious effects on organs that were not targets of the study [34]. The micronucleus test revealed no structural or numerical chromosome damage in dividing cells of animals treated with C. multijuga oil-containing eye drops, which would therefore not predispose to the occurrence of genetic diseases or neoplasms in exposed individuals.…”
Section: Discussionmentioning
confidence: 86%
“…used the liver comet assay and peripheral blood and bone marrow micronucleus tests to investigate the acute genotoxic potential of a single administration to mice of copaiba oil by gavage at doses of 500, 1000 and 2000 mg/kg and observed no cytotoxic or genotoxic effect. Furthermore, Gonçalves et al [34] demonstrated that the oral administration of C. multijuga oleoresin (200, 500 and 2500 mg/kg, for 8 consecutive weeks) exerted no toxic effect on the reproductive system of male rats.…”
Section: Groupmentioning
confidence: 99%
“…β ‐Caryophyllene is a major compound in CmOR, CpbOR, CtOR, commercial C−I, C–II, C–III, C–IV and C–VI samples, displaying more than 40 % in CmOR and commercial C–III samples. Cascon and Gilbert , and Gonçalves et al . reported high concentration (>50 %) of this compound in C. multijuga samples.…”
Section: Resultsmentioning
confidence: 76%