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Cited by 65 publications
(41 citation statements)
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References 29 publications
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“…The lowering of plasma total cholesterol, triglyceride and low density lipoprotein-cholesterol levels and significant increase in high density lipoprotein-cholesterol level in the treated animals clearly confirmed the presence of hypolipidemic agents in the extracts of P. glaucus and standard drug gibenclamide compared to untreated diabetic rats could be inactiva-ting HMG-CoA reductase. The presence of secondary metabolites such as polyphenols, alkaloids, flavonoid, tannins and terpenoidin P. glaucus extract may contri-bute in protecting the ß cells of pancreas and thus producing hypoglycemic and hypolipidemic activity (Juárez-Rojop et al, 2014). The ability of the extracts to manage hyperlipidemia is a potential beneficial effect on cardiovascular risk factors which is a major cause of death in diabetes mellitus .…”
Section: Discussionmentioning
confidence: 99%
“…The lowering of plasma total cholesterol, triglyceride and low density lipoprotein-cholesterol levels and significant increase in high density lipoprotein-cholesterol level in the treated animals clearly confirmed the presence of hypolipidemic agents in the extracts of P. glaucus and standard drug gibenclamide compared to untreated diabetic rats could be inactiva-ting HMG-CoA reductase. The presence of secondary metabolites such as polyphenols, alkaloids, flavonoid, tannins and terpenoidin P. glaucus extract may contri-bute in protecting the ß cells of pancreas and thus producing hypoglycemic and hypolipidemic activity (Juárez-Rojop et al, 2014). The ability of the extracts to manage hyperlipidemia is a potential beneficial effect on cardiovascular risk factors which is a major cause of death in diabetes mellitus .…”
Section: Discussionmentioning
confidence: 99%
“…Carica papaya (papaya) originated from the tropical regions of Mexico and America but is now widely distributed throughout the tropics and subtropics of the world [1]. The C. papaya is a fast growing, erect and typically unbranched herbaceous tree, with hollow trunk of about 20 cm in diameter [2].…”
Section: Introductionmentioning
confidence: 99%
“…The ripe or unripe fruit as well as other different parts of C. papaya have been reported to possessing wide range of biological applications [1,[19][20][21][22]. The present study was aimed to identify the phytocomponents of Aqueous Extract of Unripe Fruit (AqEUF) of C. papaya that are likely responsible for its biologic activity using GC-MS analytical protocols.…”
Section: Introductionmentioning
confidence: 99%
“…The flesh part of ripe papaya fruit has sweet and delicate taste, rich with multiple vitamins (C, E and A) and contains an excellent source of folic acid, potassium, copper, phosphorous and iron. Many published clinical evidence had shown the presence of phytochemicals in papaya leaves contributes to its multiple functional role as a remedy for diabetes treatment (Juárez-Rojop et al, 2014), anti-inflammatory effect (Owoyele et al, 2008), immunomodulatory effects (Otsuki et al, 2010), chemopreventive effects (Tan et al, 2014), antiplasmodial effect (Ahmad et al, 2011) and analgetic activity (Hasimun et al 2014).…”
Section: Introductionmentioning
confidence: 99%