Arterial lactate as a predictor of postoperative complications in head and neck squamous cell carcinoma

Souza, Suzane Pereira de; Serra, Maurício Gomes da Silva; Oliveira, Neyara dos Santos; Oliveira, Márcio Campos; Bessa, José de; Reis, Tércio Guimarães

doi:10.1016/j.bjorl.2021.04.008

Cited by 4 publications

(3 citation statements)

References 21 publications

(27 reference statements)

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“… 50 A study identified arterial cutoff lactate level >1.7 mmol/L as a marker for the rising risk of postoperative complications in the neck and head surgery with 65.38% sensitivity and 66.67% specificity. 51 …”

Section: Resultsmentioning

confidence: 99%

Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review

AL-shiakh

2023

SAGE Open Medicine

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Objective: In the Emergency Department, the physician’s purpose is to rapidly and accurately diagnose the severity of a patient’s condition so that proper treatment can be administered. Therefore, this study pays close attention to the association and prognostic value of blood lactate on different disease outcomes by systematically reviewing recently published studies. Methods: The search strategy was developed based on searches in the year 2022 for potential publications including original articles, case reports, and reviews using the following web databases google scholar, PubMed, and Science Direct. A total of 25 studies were identified and reviewed extensively to evaluate the link between mortality and serum lactate levels. Results: This literature review presents the strong association of elevated serum lactate levels with the in-hospital mortality rate among emergency department patients. Conclusion: These findings suggest that even a moderately raised lactate level in serum can predict the severe outcome in emergency department patients suffering from different conditions. Therefore, early (at the time of administration of hospital) and periodic serum lactate value determination through different techniques and scores is of need and should become part of routine analyses in emergency department to predict and choose therapies that could benefit critically ill patients.

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Section: Resultsmentioning

confidence: 99%

Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review

AL-shiakh

2023

SAGE Open Medicine

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“…Arterial lactate is a biochemical element which is elevated in acute inflammatory phases with different etiologies. Lactate is also a strong predictor of a longer duration of the surgical procedure and prolonged hospital stay [ 26 ]. Besides, older age, lower oxygen index and elevated CRP are known factors associated with complications and poor outcomes, which is consistent with the finding of the present study.…”

Section: Discussionmentioning

confidence: 99%

Systemic immune-inflammation index within the first postoperative hour as a predictor of severe postoperative complications in upper abdominal surgery: a retrospective single-center study

et al. 2022

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Background Systemic pro-inflammatory factors play a critical role in mediating severe postoperative complications (SPCs) in upper abdominal surgery (UAS). The systemic immune-inflammation index (SII) has been identified as a new inflammatory marker in many occasions. The present study aims to determine the association between SII and the occurrence of SPCs after UAS. Methods Included in this study were 310 patients with upper abdominal tumors who received UAS and subsequently were transferred to the anesthesia intensive care unit between November 2020 and November 2021 in Nanjing Drum Hospital. SPCs, including postoperative pulmonary complications (PPCs), major adverse cardiac and cardiovascular events, postoperative infections and delirium, were recorded during the hospital stay. The clinical features of the patients with and without SPCs were compared by Student’s t-test or Fisher’s exact test as appropriate. Risk factors associated with SPC occurrence were evaluated by univariable and multivariable logistic regression analyses. Receiver operating characteristic (ROC) curve analysis was used to establish a cut-off level of SII value to predict SPCs. Results Of the 310 patients receiving UAS, 103 patients (33.2%) presented at least one SPC, including PPCs (n = 62), adverse cardiovascular events (n = 22), postoperative infections (n = 51), and delirium (n = 5). Both preoperative SII and 1-h postoperative SII in patients with SPCs were significantly higher than those in patients without SPCs. Multivariate analysis showed that 1-h postoperative SII was an independent predictor for SPC occurrence (OR = 1.000, 95% CI 1.000–1.000, P = 0.007), together with postoperative C-reactive protein, postoperative arterial lactate, postoperative oxygenation-index and older age. The ROC curve showed that the optimal cutoff value of 1-h postoperative SII to predict SPCs was 754.6078 × 109/L, with an 88.3% sensitivity and a 29% specificity. Multivariate analysis also confirmed that 1-h postoperative SII > 754.6078 × 109/L was associated with increased SPC occurrence (OR = 2.656, 95% CI 1.311–5.381, P = 0.007). Conclusion Our findings demonstrated an association between the higher level of 1-h postoperative SII and SPCs, suggesting that 1-h postoperative SII, especially categorized 1-h postoperative SII using cutoff value, may be a useful tool for identifying patients at risk of developing SPCs.

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“…In head and neck surgical patients, normalization of hyperlactatemia is crucial to decrease mortality and postoperative complications [2]. However, even in critically-ill surgical patients, hyperlactatemia is not necessarily indicative of circulatory failure [3].…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Hyperlactatemia during Facial Gender Affirmation Surgery

Sarathy,

Bhethanabotla,

Mohan

et al. 2024

J Clin Med Surgery

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Hyperlactatemia is defined as elevations in blood lactate >2 mmol above baseline without concurrent metabolic acidosis [1]. Prolonged hyperlactatemia can be an independent risk factor for worse outcomes as lactate is a byproduct of anaerobic metabolism and linked with tissue ischemia and/or organ dysfunction. In head and neck surgical patients, normalization of hyperlactatemia is crucial to decrease mortality and postoperative complications [2]. However, even in critically-ill surgical patients, hyperlactatemia is not necessarily indicative of circulatory failure [3]. Our center has anecdotally noted hyperlactatemia in patients undergoing Facial Gender-Affirmation Surgery (FGAS), but it remains unclear whether it corresponds directly to adverse clinical outcomes. The present study sought to examine implications of intraoperative hyperlactatemia during FGAS.

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Arterial lactate as a predictor of postoperative complications in head and neck squamous cell carcinoma

Cited by 4 publications

References 21 publications

Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review

Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review

Systemic immune-inflammation index within the first postoperative hour as a predictor of severe postoperative complications in upper abdominal surgery: a retrospective single-center study

Intraoperative Hyperlactatemia during Facial Gender Affirmation Surgery

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