Olfactory dysfunction in COVID-19: a marker of good prognosis?

Mendonça, Cindy Vitalino; Neto, José Arruda Mendes; Suzuki, Fábio Akira; Orth, Marlon Steffens; Neto, Hugo Machado; Nacif, Sérgio Roberto

doi:10.1016/j.bjorl.2020.12.002

Cited by 24 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies have shown that anosmia, an upper respiratory tract symptom, is associated with a good prognosis in patients with COVID-19. 9,10 In the present study, nonsystemic symptoms, such as cough, anosmiaageusia, and postnasal drip, were more common in the first wave. In contrast, systemic symptoms, such as fever and shortness of breath, were more common in the second wave.…”

Section: Discussionsupporting

confidence: 43%

Cardiovascular Involvement and Mortality With New Covid-19 Variants

Coşgun

2021

Pak Heart J

View full text Add to dashboard Cite

Objectives: The presence of cardiac involvement is accepted as an indicator of morbidity and mortality in Coronavirus disease 2019 (COVID-19) patients. Therefore, this study investigates data on cardiovascular involvement and clinical outcomes between the first wave with wild virus and mutation-dominant second wave of the COVID-19 outbreak. Methodology: This was a single centre, retrospective study using and the data was collected from confirmed COVID-19 patients. Patients’ demographic and clinical characteristics, cardiovascular involvement, and the factors associated with mortality were analysed. All these data were compared between first (wild virus) and second-wave (mutant viruses) patients. Results: The study included 476 positive inpatients confirmed by a real-time polymerase chain reaction. Although the length of hospital stay was similar, the duration of intensive care units (ICUs) was longer in the second wave (6.3 ± 3.2 vs. 7.5 ± 3.5; p=0.020). The rate of severe illness (12.9 vs. 20.3%; p=0.037) and critical illness referral to ICUs (4.3 vs. 9.7%; p=0.031) was higher in the second wave than in the first. In addition, the incidence of myocardial damage was significantly higher in the second wave (4.3 vs. 10.7%; p=0.046). Conclusion: In the present study, myocardial injury, development of critical illness, and referral to the ICUs increased in correlation with the disease severity in the second wave compared to the first. Variant viruses and possibly the burden of the crowd on healthcare contribute to this situation. Therefore, epidemiological data are required to guide situational awareness as long as the pandemic remains.

show abstract

Section: Discussionsupporting

confidence: 43%

Cardiovascular Involvement and Mortality With New Covid-19 Variants

Coşgun

2021

Pak Heart J

View full text Add to dashboard Cite

show abstract

“…A study reported that patients with anosmia have a lower mortality rate and intensive care unit (ICU) admission (Talavera et al 2020). Similarly, olfaction complaints were reported more in patients with mild flu syndrome than in patients with severe flu syndrome (Mendonça et al 2021). Some previous systematic reviews and meta-analyses demonstrated the prevalence and various relevant factors that affect chemosensory dysfunction in COVID-19 (Aziz et al 2021;Hajikhani et al 2020;Tong et al 2020;von Bartheld et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The World Health Organization (WHO), two months after it declared the COVID-19 pandemic on May 2020, recognized alterations in the perception of smell and taste as symptoms of this disease (11). The described cardinal symptoms are more often observed in the population of young (not yet explained why) female patients (more frequently than males) and able-bodied, where the disease spreads more easily (12,13). A significantly higher prevalence of patients with COVID-19 who have lost their taste and smell is treated at home (rare hospitalization), they are less likely to have lung damage, less likely to receive oxygen therapy and they have mild lymphopenia (4,9).…”

Section: Marker Of Sars-cov-2 Infection or Related Anosmia And Ageusiamentioning

confidence: 99%

“…A significantly higher prevalence of patients with COVID-19 who have lost their taste and smell is treated at home (rare hospitalization), they are less likely to have lung damage, less likely to receive oxygen therapy and they have mild lymphopenia (4,9). In the literature, the opinion is represented for all the above, that the loss of odor is a prognostic and predictive sign of a less severe form of coronavirus infection (12)(13)(14). But there are studies that have the opposite opinion and advocate the view that there is no difference in the rate of hospitalization or in the severity of the disease between patients with and without sensory disorders in smell and taste (9,15).…”

Section: Marker Of Sars-cov-2 Infection or Related Anosmia And Ageusiamentioning

confidence: 99%

The importance of smell and taste in everyday life: Dysfunction in COVID-19 patients

Stanojlović¹

2021

Medicinski podmladak

View full text Add to dashboard Cite

Human-to-human transmission of coronavirus (SARS-CoV-2) - COVID-19 (corona virus disease 2019) - is characterized by a pandemic exponential rate and the patients with mild to moderate infection have odor and taste problems that represent a new atypical disease. A new viral syndrome of acute anosmia or "new loss of taste or smell" without rhinitis and nasal obstruction or rhinorrhea has been placed on the list of symptoms that may occur 2 to 14 days after exposure to the COVID-19 virus. Two months after declaring the COVID-19 pandemic in May 2020, the World Health Organization (WHO) has recognized changes in the perception of smell and taste as symptoms of this disease. The described cardinal symptoms are more common in the population of young patients and able-bodied people which facilitates the spread of disease. Significantly higher prevalence of patients with COVID-19 who have lost their taste and smell is treated at home (rare hospitalization), lung damage is rare, as well as oxygen therapy with mild lymphopenia. Different scenarios of SARS-CoV-2 viral infection can be assumed: it is probable that the virus does not enter directly into olfactory sensory neurons (they do not have ACE2 and TMPRSS2 receptors), but it is localized to vascular pericytes and causes inflammatory processes and vasculopathies. On the other hand, direct infection of non-neuronal cells which contain said receptors is possible. Those are specific cell types in the olfactory epithelium such as sustentacular, horizontal basal cells, as well as Bowman's glands, which leads to massive degeneration and loss of olfactory neurons. The sense of taste is a complex sensation that is the result of the interaction of smell, taste, temperature and texture of food. The virus damages cranial nerves, epithelial receptors and blood vessels leading to taste damage (ageusia or dysgeusia). A multidisciplinary approach with epidemiological, clinical and basic research is needed to elucidate the mechanism of sensorineural odor and taste loss caused by coronavirus.

show abstract

Olfactory dysfunction in COVID-19: a marker of good prognosis?

Cited by 24 publications

References 22 publications

Cardiovascular Involvement and Mortality With New Covid-19 Variants

Cardiovascular Involvement and Mortality With New Covid-19 Variants

Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis

The importance of smell and taste in everyday life: Dysfunction in COVID-19 patients

Contact Info

Product

Resources

About