Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma

Abakay, Mehmet Akif; Güneş, Selçuk; Gülüstan, Filiz

doi:10.1016/j.bjorl.2020.07.012

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…These two characteristics were deemed strong prognostic factors in previous studies. It was reported that harvested lymph nodes (HLNs) ≥18 indicated favorable survival outcomes and tumor control, 21 and a ratio of harvested lymph nodes to metastatic lymph nodes (LNR) > 6% predicted significantly lower OS and DFS rates 22 . It was also reported that total nodal volume (TNV) could be an independent prognostic factor, and for patients with TNV > 15 cc, elective neck dissection after CCRT may be necessary 23 .…”

Section: Discussionmentioning

confidence: 99%

A Nomogram to Predict Nodal Response after Induction Chemotherapy for Hypopharyngeal Carcinoma

Hsueh

Huang

et al. 2022

The Laryngoscope

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Background For hypopharyngeal carcinoma, metastatic neck nodes with a low response to induction chemotherapy (ICT) should not be managed with concomitant chemoradiotherapy (CCRT), and the prediction of chemosensitivity before ICT could prevent adverse events from occurring during chemotherapy. In this study, we developed a nomogram to predict the regional response to ICT. Methods A total of 153 hypopharyngeal carcinoma patients with regional metastasis treated with ICT in our institution from January 2010 to September 2020 were retrospectively studied. According to ICT response evaluated by RECIST 1.1, patients were divided into chemo‐insensitive (PR < 70%/SD/PD) (group 1) and chemosensitive (CR/PR ≥ 70%) (group 2) groups. Patients' clinical, image, and hematologic data before ICT were collected. The nomogram was built based on multivariate analysis and stepwise logistic regression and was evaluated from the aspects of discrimination and calibration. Results A nomogram based on five critical predictors, namely, tumor differentiation degree, T classification, metastatic lymph node size, number of lymph node metastases, and cervical nodal necrosis, was developed. The areas under the curve (AUC) values were 0.76 and 0.70 after adjusting the results using bootstrap methods. The calibration curve showed relatively good agreement between the predicted and observed probabilities. Conclusions Our nomogram yielded good accuracy in predicting the regional ICT response and will be a useful tool to assist clinicians in decision making. Level of Evidence 4 Laryngoscope, 133:849–855, 2023

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Section: Discussionmentioning

confidence: 99%

A Nomogram to Predict Nodal Response after Induction Chemotherapy for Hypopharyngeal Carcinoma

Hsueh

Huang

et al. 2022

The Laryngoscope

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Novel Prognostic Models Predicting the Cancer-Specific Survival in Patients with Cutaneous Melanoma Based on Metastatic Lymph Node Status

Zhang

2021

Ann Surg Oncol

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Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma

Cited by 2 publications

References 17 publications

A Nomogram to Predict Nodal Response after Induction Chemotherapy for Hypopharyngeal Carcinoma

A Nomogram to Predict Nodal Response after Induction Chemotherapy for Hypopharyngeal Carcinoma

Novel Prognostic Models Predicting the Cancer-Specific Survival in Patients with Cutaneous Melanoma Based on Metastatic Lymph Node Status

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