Survival results of 3786 patients with stage I or II laryngeal squamous cell carcinoma: a study based on a propensity score

Carvalho, Genival Barbosa de; Köhler, Hugo Fontan; Lira, Renan Bezerra; Vartanian, José Guilherme; Kowalski, Luiz Paulo

doi:10.1016/j.bjorl.2020.06.007

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…1,2 Management of early laryngeal cancer (stages T1 and T2a, without regional metastatic disease) must balance oncologic success and minimal treatment morbidity. 3,4 Endoscopic surgery has progressed in technology of surgical tools and endoscopes, with laser resection dominating the field. Mucosal lesion extent and vocal cord mobility are easy to assess endoscopically, but limits and issues in early glottic cancer diagnostics are also evident, especially with inability to accurately assess tumor extension into deep laryngeal soft tissue, the anterior commissure, or the subglottic area.…”

Section: Discussionmentioning

confidence: 99%

“…Laryngeal cancer represents a major challenge in diagnosis and treatment, given the importance, role, and location of the larynx in humans and the posttherapeutic impact on quality of life 1,2 . Management of early laryngeal cancer (stages T1 and T2a, without regional metastatic disease) must balance oncologic success and minimal treatment morbidity 3,4 . Endoscopic surgery has progressed in technology of surgical tools and endoscopes, with laser resection dominating the field.…”

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confidence: 99%

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Diagnostic Accuracy of Preoperative CT and Endoscopy Staging in Early Laryngeal Cancer

Stevanović

Gregurić²,

Pažanin

et al. 2022

Otolaryngol.--head neck surg.

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Objectives This study aims to evaluate the diagnostic accuracy of preoperative computed tomography (CT) and intraoperative endoscopic tumor staging with regard to histopathologic staging in patients with early laryngeal cancer. Study Design A retrospective nonrandomized single-institution comparative cohort study including 109 patients. Setting A tertiary surgical center. Methods Patients were treated for T1a, T1b, and T2a laryngeal squamous cell carcinoma by endoscopic laser surgery. The outcome measures were the presence of under- or overstaging in endoscopic and CT findings and positive postoperative margins. Results Endoscopic overstaging as compared with histopathologic T category correlated with rising tumor category ( P = .001; odds ratio [OR], 69.1) and CT findings showing anterior commissure involvement ( P = .002; OR, 9.54), while endoscopic understaging correlated with rising tumor histologic grade ( P = .039; OR, 4.28) and smaller tumor size ( P = .011; OR, 6.39). CT overstaging vs histopathologic T category correlated with CT findings showing anterior commissure involvement ( P = .001; OR, 21.76), supraglottic involvement ( P = .001; OR, 59.98), subglottic involvement ( P = .001; OR, 39.94), rising clinical T category ( P = .01; OR, 9.11), and rising tumor histologic grade ( P = .004; OR, 10.95). CT understaging as compared with histopathologic T category correlated with smaller clinical T categories ( P = .002; OR, 12.72) and smaller tumor histologic grade ( P = .030; OR, 7.02). Rising age, rising tumor size, anterior commissure involvement on CT, and tumor extension into the supraglottis were risk factors for positive margins. Conclusion Our results indicate that CT adds little valuable information in differentiating small superficial lesions in the glottis, while systematically overstaging cases of early laryngeal cancer. In T1a and T1b glottic tumors, endoscopy should be the preferred diagnostic method.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Diagnostic Accuracy of Preoperative CT and Endoscopy Staging in Early Laryngeal Cancer

Stevanović

Gregurić²,

Pažanin

et al. 2022

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

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“…It is induced by various risk factors, such as smoking, drinking and human papillomavirus infection ( 1 ). At present, the main treatment strategies for laryngeal cancer are surgery, radiotherapy as well as chemotherapy ( 2 ). Under the goals of maintaining speech and swallowing functions, some patients have experienced relapse and require salvage treatment.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of an Immune-Related Signature for the Prediction of Recurrence Risk of Patients With Laryngeal Cancer

et al. 2021

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ObjectiveOur purpose was to develop and verify an immune-related signature for predicting recurrence risk of patients with laryngeal cancer.MethodsRNA-seq data of 51 recurrence and 81 non-recurrence laryngeal cancer samples were downloaded from TCGA database, as the training set. Microarray data of 34 recurrence and 75 non-recurrence cancer samples were obtained from GEO dataset, as the validation set. Single factor cox regression was utilized to screen prognosis-related immune genes. After LASSO regression analysis, an immune-related signature was constructed. Recurrence free survival (RFS) between high- and low- recurrence risk patients was presented, followed by ROC. We also evaluated the correlation between immune infiltration and the signature using the CIBERSORT algorithm. The genes in the signature were validated in laryngeal cancer tissues by western blot or RT-qPCR. After RCN1 knockdown, migration and invasion of laryngeal cancer cells were investigated.ResultsTotally, 43 prognosis-related immune genes were identified for laryngeal cancer. Among them, eight genes were used for constructing a prognostic signature. High risk group exhibited a higher recurrence risk than low risk group. The AUC for 1-year was separately 0.803 and 0.715 in the training and verification sets, suggesting its well efficacy for predicting the recurrence. Furthermore, this signature was closely related to distinct immune cell infiltration. RCN1, DNAJA2, LASP1 and IBSP were up-regulated in laryngeal cancer. RCN1 knockdown restrained migrated and invasive abilities of laryngeal cancer cells.ConclusionOur findings identify a reliable immune-related signature that can predict the recurrence risk of patients with laryngeal cancer.

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“…2 Although there are data indicating that the disease-specific survival rate of surgical treatment is better than that of radiotherapy, the survival rate of LSCC has not been substantially improved in the past half century. 3 At present, the exact pathogenesis of LSCC is still unclear. Despite more and more studies conducted on the recognition of tumor markers, there are few tumor markers that can be used clinically to assist diagnosis and treatment of LSCC.…”

Section: Introductionmentioning

confidence: 99%

“…Usually, the therapeutic methods of LSCC mainly include surgery, radiotherapy, chemotherapy, and comprehensive treatment mode 2 . Although there are data indicating that the disease‐specific survival rate of surgical treatment is better than that of radiotherapy, the survival rate of LSCC has not been substantially improved in the past half century 3 . At present, the exact pathogenesis of LSCC is still unclear.…”

Section: Introductionmentioning

confidence: 99%

HAGLROS promotes cell proliferation and angiogenesis and inhibits apoptosis by activating multiple signaling pathways in LSCC cells

Zhang

et al. 2021

J Oral Pathology Medicine

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Background HAGLROS is a long noncoding RNA involving in the development of a variety of cancers, but its mechanism of action in laryngeal squamous cell carcinomas (LSCC) is still unclear. We aim to unveil the effect and mechanism of HAGLROS on LSCC. Methods The expression of HAGLROS in LSCC patients’ tissues, serum, and LSCC cell lines was quantified by quantitative real‐time PCR. AMC‐HN‐8 and SNU‐46 cells were transfected with the overexpression plasmid of HAGLROS and shHAGLROS, and the functional assay (colony formation assays, flow cytometry, and tube formation) was performed. Western blot was used to determine the expressions of vascular endothelial growth factor (VEGF), proliferating cell nuclear antigen (PCNA), P27 and cleaved caspase‐3, as well as phosphorylated‐c‐Jun‐N‐terminal kinase (p‐JNK), JNK, phosphorylated‐extracellular signal‐regulated kinase 1/2 (p‐Erk1/2), Erk1/2, phosphorylated‐protein kinase B (p‐AKT) and AKT. Results HAGLROS was highly expressed in LSCC tissues and cells, and it was correlated to lymph node, tumor depth, and clinical stage of LSCC patients. The proliferation ability of LSCC cells was higher than that of HuLa‐PC cells. Meanwhile, HAGLROS overexpression promoted the abilities of proliferation and angiogenesis and reduced apoptosis, whereas silencing of HAGLROS exerted the opposite effects in LSCC cell lines. Moreover, overexpressed HAGLROS upregulated the expressions of VEGF and PCNA yet downregulated the expressions of P27 and cleaved caspase‐3 by activating Erk1/2 and AKT or JNK signaling pathways in different LSCC cell lines. Conclusion Overexpressed HAGLROS promoted the proliferation and angiogenesis yet inhibited apoptosis of LSCC cells by activating Erk1/2 and AKT or JNK signaling pathways.

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Survival results of 3786 patients with stage I or II laryngeal squamous cell carcinoma: a study based on a propensity score

Cited by 5 publications

References 23 publications

Diagnostic Accuracy of Preoperative CT and Endoscopy Staging in Early Laryngeal Cancer

Diagnostic Accuracy of Preoperative CT and Endoscopy Staging in Early Laryngeal Cancer

Development and Validation of an Immune-Related Signature for the Prediction of Recurrence Risk of Patients With Laryngeal Cancer

HAGLROS promotes cell proliferation and angiogenesis and inhibits apoptosis by activating multiple signaling pathways in LSCC cells

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