The maturation state of the auditory nerve and brainstem in rats exposed to lead acetate and supplemented with ferrous sulfate

Zucki, Fernanda; Morata, Thaís C.; Duarte, Josilene Luciene; Ferreira, Manuela; Salgado, Manoel Henrique; Alvarenga, Kátia de Freitas

doi:10.1016/j.bjorl.2016.12.004

Cited by 3 publications

(1 citation statement)

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“…It was found that the administration of both synthetic and natural antioxidants has impressive effects on the prevention of metal-induced biochemical alterations, but the numbers of clinical studies in this field are still limited. For this purpose, Zucki et al [ 184 ] investigated the auditory system and its maturation, particularly the auditory nerve and brainstem, in rats that were exposed to lead acetate and supplemented with ferrous sulfate as an antioxidant agent. In this study, 15 male rats were exposed to 100 mg/L of lead acetate with ferrous sulfate (20 mg/kg), and 15 rats were exposed to 400 mg/L of lead with ferrous sulfate (20 mg/kg) within their drinking water for 6 weeks.…”

Section: Role Of Antioxidant Materials In the Tissue Regeneration Pro...mentioning

confidence: 99%

Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature

et al. 2023

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Oral and maxillofacial tissue defects caused by trauma, tumor reactions, congenital anomalies, ischemic diseases, infectious diseases, surgical resection, and odontogenic cysts present a formidable challenge for reconstruction. Tissue regeneration using functional biomaterials and cell therapy strategies has raised great concerns in the treatment of damaged tissue during the past few decades. However, during biomaterials implantation and cell transplantation, the production of excessive reactive oxygen species (ROS) may hinder tissue repair as it commonly causes severe tissue injuries leading to the cell damage. These products exist in form of oxidant molecules such as hydrogen peroxide, superoxide ions, hydroxyl radicals, and nitrogen oxide. These days, many scientists have focused on the application of ROS-scavenging components in the body during the tissue regeneration process. One of these scavenging components is antioxidants, which are beneficial materials for the treatment of damaged tissues and keeping tissues safe against free radicals. Antioxidants are divided into natural and synthetic sources. In the current review article, different antioxidant sources and their mechanism of action are discussed. The applications of antioxidants in the regeneration of oral and maxillofacial tissues, including hard tissues of cranial, alveolar bone, dental tissue, oral soft tissue (dental pulp, periodontal soft tissue), facial nerve, and cartilage tissues, are also highlighted in the following parts.

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Section: Role Of Antioxidant Materials In the Tissue Regeneration Pro...mentioning

confidence: 99%

Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature

et al. 2023

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Molecular mechanism of selenium against lead-induced apoptosis in chicken brainstem relating to heat shock protein, selenoproteins, and inflammatory cytokines

Chen,

Yu,

Hao

et al. 2024

Ecotoxicology and Environmental Safety

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Participation of phospholipase-A2 and sphingomyelinase in the molecular pathways to eryptosis induced by oxidative stress in lead-exposed workers

Hernández

Villanueva-Ibarra

Maldonado-Vega

et al. 2019

Toxicology and Applied Pharmacology

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The maturation state of the auditory nerve and brainstem in rats exposed to lead acetate and supplemented with ferrous sulfate

Abstract: This study indicate that the lead acetate can have deleterious effects on the maturation of the auditory nerve and brainstem (cochlear nucleus region), as detected by the Brainstem Auditory Evoked Potentials, and the ferrous sulphate can partially amend this effect.

Cited by 3 publications

References 36 publications

Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature

Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature

Molecular mechanism of selenium against lead-induced apoptosis in chicken brainstem relating to heat shock protein, selenoproteins, and inflammatory cytokines

Participation of phospholipase-A2 and sphingomyelinase in the molecular pathways to eryptosis induced by oxidative stress in lead-exposed workers

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