Diagnosis and comprehensive therapy for cutaneous neuroendocrine carcinoma of the external auditory canal: a case report and literature review

Xiu, Qian; Wang, Xueju; Zhu, Dan; Meng, Cuida

doi:10.1016/j.bjorl.2016.02.005

Brazilian Journal of Otorhinolaryngology

2018

DOI: 10.1016/j.bjorl.2016.02.005

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Diagnosis and comprehensive therapy for cutaneous neuroendocrine carcinoma of the external auditory canal: a case report and literature review

Qian Xiu

Xueju Wang

Dan Zhu

et al.

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Cited by 4 publications

(3 citation statements)

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“…Well-differentiated primary neuroendocrine tumors with external auditory canal location are extremely rare [4][5][6][7]. Surgical excision and additional radiation therapy have been reported as the preferred methods in disease management in the current literature 4,5,8.…”

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confidence: 99%

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68Ga-DOTATATE Uptake in Well-Differentiated Neuroendocrine Tumor of the External Auditory Canal

Fenercioğlu¹,

Beyhan²,

Şahin³

et al. 2022

Clin Nucl Med

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A 38-year-old woman presented with a 4-month history of leftsided otalgia and otorrhea. Otoscopy revealed a mass in the left external auditory canal causing obliteration. A biopsy was taken, and the diagnosis was consistent with a well-differentiated neuroendocrine tumor. The patient was referred to our department for staging with 68 Ga-DOTATATE PET/CT. Increased radiopharmaceutical uptake was observed in the primary tumor and metastatic lymph nodes.

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mentioning

confidence: 99%

“…[4][5][6][7] Surgical excision and additional radiation therapy have been reported as the preferred methods in disease management in the current literature. 4,5,8…”

mentioning

confidence: 99%

68Ga-DOTATATE Uptake in Well-Differentiated Neuroendocrine Tumor of the External Auditory Canal

Fenercioğlu¹,

Beyhan²,

Şahin³

et al. 2022

Clin Nucl Med

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“…Cutaneous low-grade neuroendocrine tumor (cLGNET) has infrequently been reported in the literature and typically present on the scalp or trunk of elderly patients (3). To the best of our knowledge, only six cases of NENs of the external ear have been reported (4)(5)(6)(7)(8)(9). The majority of these cases were diagnosed as high-grade MCC; none have described a cLGNET (4)(5)(6)(7).…”

mentioning

confidence: 99%

A Rare Presentation of Primary Cutaneous Low-Grade Neuroendocrine Tumor of the External Auditory Canal

Bhardwaj

Tanenbaum

Nguy³

et al. 2021

Otology &Amp; Neurotology

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Objective: To describe the first case of a primary cutaneous low-grade neuroendocrine tumor (cLGNET) originating from the external auditory canal as well as our team's surgical management. Patient: A healthy 34-year-old female presented with a lowgrade neuroendocrine tumor of her right external auditory canal (EAC) which extended from the posterior-superior aspect of the EAC into the middle ear. Intervention: A complete otological examination was performed in addition to CT and MRI imaging. The low-grade neuroendocrine tumor was surgically biopsied and further surgery was recommended for complete resection. Results: Audiogram revealed profound right sensorineural hearing loss. CT scan demonstrated complete opacification of the right EAC, middle ear, and mastoid air cells, dystrophic calcification in the mesotympanum overlying the cochlear promontory, and no associated osseous erosion. MRI revealed abnormal FLAIR hyperintensity and enhancement of the labyrinthine segment of the right facial nerve, cochlea, and horizontal and posterior semicircular canals. An enhancing mass opacifying the right EAC demonstrating restricted diffusion on diffusion-weighted image was also evident. Pathologic examination and immunohistochemical staining confirmed a diagnosis of primary cLGNET of the EAC. Conclusion: Primary cLGNETs of the external ear are exceedingly rare but should be considered if an adult patient presents with a mass in the EAC. Management should include early biopsy and surgical excision followed by histological and immunohistochemical confirmation.

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Exploring diagnosis and therapeutic complexities of an aggressive Merkel cell carcinoma: A case report and review of the literature

de Carvalho Kimura,

Takahiro Chone,

Agustin Vargas

et al. 2023

Oral Oncology

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Diagnosis and comprehensive therapy for cutaneous neuroendocrine carcinoma of the external auditory canal: a case report and literature review

Cited by 4 publications

References 10 publications

68Ga-DOTATATE Uptake in Well-Differentiated Neuroendocrine Tumor of the External Auditory Canal

68Ga-DOTATATE Uptake in Well-Differentiated Neuroendocrine Tumor of the External Auditory Canal

A Rare Presentation of Primary Cutaneous Low-Grade Neuroendocrine Tumor of the External Auditory Canal

Exploring diagnosis and therapeutic complexities of an aggressive Merkel cell carcinoma: A case report and review of the literature

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