Carcinoma ex-pleomorphic adenoma derived from recurrent pleomorphic adenoma shows important difference by array CGH compared to recurrent pleomorphic adenoma without malignant transformation

Mariano, Fernanda Viviane; Giovanetti, Karina; Saccomani, Luis Fernando Vidal; Negro, André Del; Kowalski, Luiz Paulo; Krepischi, Ana Cristina Victorino; Altemani, Albina

doi:10.1016/j.bjorl.2015.12.004

Cited by 9 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The overall rates of malignant transformation from primary tumors and recurrent tumors have been frequently used as supporting evidence of the malignancy-promoting effect of recurrence or repeated surgeries [ 10 , 11 , 12 , 13 ]. Therefore, we calculated the overall incidence of malignant transformation in our series, which was 5.9% in primary tumor cases and 20.0% in recurrent cases ( p = 0.011) ( Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Longitudinal Analysis of Malignant Transformation in Pleomorphic Adenoma and Recurrent Pleomorphic Adenoma

Choi

Hwang

et al. 2022

JCM

View full text Add to dashboard Cite

Background: Recurrence in pleomorphic adenoma (PA) has been debated as a risk factor for malignant transformation (MT). In this study, we investigated whether recurrence is a risk factor for MT, by longitudinally analyzing cases with recurrent PA (RPA), and carcinomas from PA (CXPA) or RPA (CXRPA). Methods: The study population included 24 CXPA, 24 RPA, 6 CXRPA, and 386 PA cases (study period 2010–2018). Time and event data were collected from the medical documents to identify the time–event sequences. Results: The time interval to MT in CXRPA was significant longer than that of benign recurrence (median 342.0 vs. 109.5 months). In CXRPA, the recurrence intervals were not shorter than those in RPA according to recurrence frequency. Crudely, the MT rate was 5.9% among primary cases and 20.0% among recurrent cases. However, the time-adjusted MT rates increased up to 11.4% (incubation time > 60 months) and 20.0% (>120 months) in primary cases, which were not different from recurrent cases. Conclusion: In these longitudinal analyses, we did not find any clinical evidence that recurrence facilitates MT in the background of PA. Instead, a long incubation time seems to be a key factor for MT of underlying RPA.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Interestingly, recurrence (itself) in PA is considered a risk factor for malignant transformation of RPA (Carcinoma ex recurrent pleomorphic adenoma, CXRPA) in some studies analyzing RPA [ 10 , 11 , 12 , 13 ]. However, how repeated recurrences or surgeries promote the occurrence of CXRPA remains unclear [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Longitudinal Analysis of Malignant Transformation in Pleomorphic Adenoma and Recurrent Pleomorphic Adenoma

Choi

Hwang

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…In addition, ERBB2 overexpression and amplification similar to those which occur in SDC [68,69], copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) [70], MDM2 amplification [71,72], loss of heterozygosity, and microsatellite alterations in the p53 and RB genes and at chromosomal location 5q [73] are all secondary genetic alterations detected in CPA and may be of importance for disease progression from PA.…”

Section: Pa and Its Progression: An Example Of Recurrent Genetic Altementioning

confidence: 99%

Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity

Rito¹,

Fonseca²

2017

Pathobiology

View full text Add to dashboard Cite

Salivary gland tumor classification encompasses a vast list of benign and malignant neoplasms. Their morphological diversity is recognized not only between different entities but also within individual tumors. Tumor categories as described by the World Health Organization reflect, in part, a true genetic heterogeneity (e.g., translocations involving CRTC1 and CRTC3-MAML2 genes in mucoepidermoid carcinoma and MYB-NFIB fusion in adenoid cystic carcinoma). Carcinoma ex pleomorphic adenoma shows diversity in its histological appearance, but recurrent rearrangements on PLAG1 and HMGA2 are common to its benign precursor. More recently, new categories have been defined, like secretory carcinoma with the t(12;15) (p13;q25) ETV6-NTRK3 translocation and clear-cell carcinoma with EWSR1-ATF1 fusion. Recent studies on cribriform adenocarcinoma of minor salivary gland origin and epithelial-myoepithelial carcinoma point to a correlation with their morphological features. All of these advances show that the search of a histogenetic and genetic basis for salivary gland tumors is helping to clarify morphological categories and unraveling new ones. Nevertheless, currently morphology is still the hallmark of tumor classification and the gold standard. The therapeutic options for advanced tumors remain very limited but the discovery of translocation-generated gene fusions and increased knowledge of the genomic information of salivary gland tumors is creating opportunities for the development of specific targeted therapies.

show abstract

“…En cuanto a la transformación maligna adenoma pleomorfo en general se reporta en 1,5% a 23% de los casos y se describe que ésta aumenta según el tiempo de evolución de la enfermedad ya que la carcinogénesis se produce en varias etapas a través de los cambios genómicos que dan lugar a la pérdida de funciones de supresores tumorales, activación de oncogenes y la fusión de genes con potencial maligno 19 . En cuanto al adenoma pleomorfo nasal, Suzuki describe 2,4% de malignización, mientras en otras series alcanza el 6% y se observa predominantemente en mujeres 10,17 , sin embargo, no se especifica a cuanto tiempo de seguimiento ni diferencias exactas de distribución por sexo.…”

Section: Discussionunclassified

Adenoma pleomorfo originado en pared lateral nasal: Reporte de un caso clínico

et al. 2019

Rev. Otorrinolaringol. Cir. Cabeza Cuello

View full text Add to dashboard Cite

show abstract

Carcinoma ex-pleomorphic adenoma derived from recurrent pleomorphic adenoma shows important difference by array CGH compared to recurrent pleomorphic adenoma without malignant transformation

Abstract: The occurrence of gains at chromosomes 3 and 8 and genomic amplifications at 8p and 12q, mainly those encompassing the HMGA2, MDM2, WIF1, WHSC1L1, LIRG3, CDK4 in CXAP from RPA can be a significant promotional factor in malignant transformation.

Cited by 9 publications

References 28 publications

Comparative Longitudinal Analysis of Malignant Transformation in Pleomorphic Adenoma and Recurrent Pleomorphic Adenoma

Comparative Longitudinal Analysis of Malignant Transformation in Pleomorphic Adenoma and Recurrent Pleomorphic Adenoma

Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity

Adenoma pleomorfo originado en pared lateral nasal: Reporte de un caso clínico

Contact Info

Product

Resources

About