Morphological analysis of the vestibular system of guinea pigs poisoned by organophosphate

Cogo, Lícia Assunção; Filha, Valdete Alves Valentins dos Santos; Murashima, Adriana de Andrade Batista; Hyppolito, Miguel Ângelo; Silveira, Aron Ferreira da

doi:10.1016/j.bjorl.2015.10.001

Cited by 9 publications

(3 citation statements)

References 14 publications

(12 reference statements)

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“…The limitation of this study was the compound's incapacity to cross the egg barrier, and no chemical analysis in the embryo was done to confirm if the pesticide reached tissues. The second study used guinea pig exposed to chlorpyrifos to evaluate the vestibular system (Cogo et al 2016). In this case, the endpoint was too specific, and there is no ototoxicity evidence in the literature related to chlorpyrifos.…”

Section: Resultsmentioning

confidence: 99%

The Toxic Effects of Glyphosate, Chlorpyrifos, Abamectin, and 2,4‐D on Animal Models: A Systematic Review of Brazilian Studies

Disner

Falcão

Andrade‐Barros

et al. 2020

Integr Envir Assess & Manag

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Brazil is a global agricultural commodity producer and the largest consumer of pesticides. Pesticide use in Brazil comprised 549 280 tons in 2018. In the country, soybean, corn, and sugar cane are extensively produced, which are the most pesticides demanding crops. In the last years, the records of new pesticides were the highest in the historical series. They can persist in soil or water, accumulate in organisms, and contaminate workers and the general population through the air, water, or food. This review aimed to gather toxicological data obtained by animal models exposed to 4 pesticides: glyphosate, chlorpyrifos, abamectin, and 2,4‐D. An additional goal was to compose an overview of how this subject has been approached, surveying which research groups are working on this field, where they are located, and relations with pesticides used in those regions. We collected the papers from the platforms PubMed, Scopus, Scielo, and Web of Science, performed in Brazil from 2014 to 2019. After two‐step blind selection using the software Rayyan QCRI by different authors, 67 studies were selected to extract data. We observed that research is more concentrated in the South region, followed by the Southeast and Midwest, with 43%, 32%, and 23% of the studies, respectively. The prevalent institutions are from the states of Rio Grande do Sul, São Paulo, and Goiás. The effects on a variety of biomarkers help predict the potential risks to humans and nontarget organisms. The prevalent animal model was fish (36%). Overall, the main toxic effects evaluated were mortality, abnormalities in the blood cells, developmental abnormalities, and behavior alterations. Integr Environ Assess Manag 2021;17:507–520. © 2020 SETAC

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Section: Resultsmentioning

confidence: 99%

The Toxic Effects of Glyphosate, Chlorpyrifos, Abamectin, and 2,4‐D on Animal Models: A Systematic Review of Brazilian Studies

Disner

Falcão

Andrade‐Barros

et al. 2020

Integr Envir Assess & Manag

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“…Cogo ve ark. [17] Guinea piglere intraperitoneal yoldan 10 gün boyunca pyrinex enjekte edip dış tüy hücreleri, utrikül ve sakkülde anlamlı değişiklik saptamamış ancak anlamsız da olsa elektron mikroskopik olarak bir fark olduğunu ve bu farkın sakkülde daha belirgin olduğunu belirtmiş-lerdir. Çalışmanın sonucunun diğer çalışmalardan farklı olmasının nedeni seçtikleri pestisit cinsi ve dozlamanın yetersiz yapılmış olması olabilir.…”

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Effect of organophosphate insecticides on vestibulocochlear system

Acıpayam¹

2018

KBB Uygulamaları

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ÖZOrganofosfatlı (OF'li) insektisitler tüm dünyada tarım işçiliğinde yaygın olarak kullanılmaktadır. Yaygın kullanımları nedeniyle OP intoksikasyonları acil servislerde sık görülmektedir. Organofosfat intoksikasyonlarının vestibülokochlear sistem üzerine etkileri bir çok hayvan çalışması üzerinde gösterilmiş olmasına rağmen, literatürde tarım işçileri üzerine az sayıda çalışma vardır. Bu derlemede, OF'lerin vestibülokochlear sistem üzerine etkileri güncel literatür eşliğinde sunuldu.Anahtar sözcükler: Tarım; organofosfatlı insektisitler; vestibülokochlear. ABSTR ACTOrganophosphate (OP) insecticides are widely used in agricultural labor all over the world. Organophosphate intoxications are frequently observed in emergency services due to their common use. Although the effects of OP intoxications over the vestibulocochlear system were demonstrated in many animal studies, there are a limited number of studies in the literature on agricultural workers. In this review, we present the effects of OPs on the vestibulocochlear system in light of the current literature.

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“…The degree of the lesion caused by those substances will depend on individual predisposition, administered dose, duration, route of administration, age, and family tendency. 10…”

Section: Introductionmentioning

confidence: 99%

The Importance of Otoneurological Evaluation in Brazilian Workers Exposed to Pesticides: A Preliminary Study

Zeigelboim

Malisky

Rosa

et al. 2019

Int Arch Otorhinolaryngol

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Introduction Agrochemicals, also known as pesticides, are widely used in agriculture and in public health. They are organic and inorganic chemical substances with a high level of toxicity not only for the environment, but also for human health. Objective To verify findings on labyrinthine assessment in endemic disease control agents, and to recommend the inclusion of the vestibular exam in the set of tests for pesticide-exposed populations. Methods Descriptive, prospective, cross-sectional study with a sample comprising 15 endemic disease control agents, males, mean age of 51.6 years old (standard deviation [SD] = 5.9). All of the participants were submitted to anamnesis, otorhinolaryngological screening, and vestibular assessment. Results Regarding the most reported complaints, dizziness (73.4%), headache (60%), and tingling in the extremities (53.4%) were observed. The findings of the vestibular exams were normal in 53.3%, while 46.7% showed peripheral vestibular disorder, of which 26.7% were of deficitary type, and 20% of the irritative type. Conclusions: Alteration in the vestibular system was verified in 50% of the workers, with a greater prevalence in the caloric testing. Several disorders related to pesticides intoxication are scientifically known. Actions promoting knowledge and qualification of this population for the proper handling of chemicals are suggested, in addition to the elaboration and inclusion of protocols of vestibular assessment in hearing health programs for the prevention, diagnosis and treatment of vestibular disorders.

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Morphological analysis of the vestibular system of guinea pigs poisoned by organophosphate

Cited by 9 publications

References 14 publications

The Toxic Effects of Glyphosate, Chlorpyrifos, Abamectin, and 2,4‐D on Animal Models: A Systematic Review of Brazilian Studies

The Toxic Effects of Glyphosate, Chlorpyrifos, Abamectin, and 2,4‐D on Animal Models: A Systematic Review of Brazilian Studies

Effect of organophosphate insecticides on vestibulocochlear system

The Importance of Otoneurological Evaluation in Brazilian Workers Exposed to Pesticides: A Preliminary Study

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