Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced squamous cell carcinoma of the larynx

Bonhin, Rodrigo Gonzalez; Rocha, Vanessa Brito Brito Campoy; Carvalho, Guilherme Machado de; Guimarães, Alexandre Caixeta; Crespo, Agrício Nubiato; Chone, Carlos Takahiro; Amstalden, Eliane Maria Ingrid

doi:10.1016/j.bjorl.2014.08.016

Cited by 6 publications

(5 citation statements)

References 21 publications

(30 reference statements)

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“…Korampalli and Stafford 11 found no differences in terms of VEGF levels in early and advanced larynx tumors. Similar to our findings, no correlations were found between VEGF level and lymph node metastasis in several studies on larynx cancer 31,32 . However, Wang et al 33 reported a significant association between VEGF and lymph node metastasis.…”

Section: Discussionsupporting

confidence: 87%

“…Similar to our findings, no correlations were found between VEGF level and lymph node metastasis in several studies on larynx cancer. 31,32 However, Wang et al 33 reported a significant association between VEGF and lymph node metastasis. We think the role of VEGF in laryngeal carcinoma needs to be further investigated in order to better understand the underlying molecular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

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Candidate Angiogenesis‐Related Biomarkers in Patients with Laryngeal Carcinoma (AngLaC): A Prospective Cohort Study

Pamuk

Gedik

Süslü

et al. 2023

Otolaryngol.--head neck surg.

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Objective. Angiogenesis is indeed a vital process in the progression of carcinomas, including that of larynx. Therefore, this study (AngLaC) aimed to identify candidate angiogenesisrelated biomarkers in laryngeal carcinoma patients.Study Design. Prospective controlled cohort study.Setting. Tertiary referral center.Methods. In silico analyses of angiogenesis-related genes in laryngeal carcinoma were performed to determine candidate biomarkers. Serum levels of candidate biomarkers were determined via enzyme-linked immunosorbent assay in laryngeal carcinoma patients as well as in an age and gender-matched control group. The associations of the biomarkers with clinical parameters were investigated.Results. The study included 60 laryngeal carcinoma patients and 20 healthy controls. The serum levels of osteopontin, IGFBP-3, VEGF, sVEGFR-1, and VEGFR-2 were significantly higher in the patient group (p < .001, p ≤ .001, p < .001, p < .01, p < .01, respectively). High osteopontin and sVEGFR-1 levels were associated with locoregional-recurrence (p = .024, p = .016, respectively). IGFBP-3 had the highest diagnostic sensitivity (81.4%) and specificity (80%) among the molecules that were investigated (p < .001). High sVEGFR-1 and low VEGFR-2 levels were associated with poor overallsurvival (p = .037, p = .027, respectively). High osteopontin and sVEGFR-1 levels were associated with poor diseasespecific survival rates (p = .035, p = .018, respectively). Conclusion.High serum levels of sVEGFR-1 and osteopontin as well as low serum levels of VEGFR-2 proved to be poor prognostic in terms of survival in laryngeal carcinoma. VEGF, sVEGFR1, VEGFR2, IGFBP-3, and osteopontin levels were found to be significantly increased in larynx cancer patients compared to the normal population. Further studies on osteopontin and sVEGFR-1 are required in order to determine their associations with recurrence.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Candidate Angiogenesis‐Related Biomarkers in Patients with Laryngeal Carcinoma (AngLaC): A Prospective Cohort Study

Pamuk

Gedik

Süslü

et al. 2023

Otolaryngol.--head neck surg.

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“…Interestingly, Wang et al even reported a strong association of VEGF expression with lymph node metastasis in primary laryngeal carcinomas [ 27 ]. In contrast, other studies did not reveal any association of angiogenesis with the presence of LN metastasis [ 25 , 28 ]. In our analysis there was no direct correlation between T- or N-stage and VEGF.…”

Section: Discussionmentioning

confidence: 67%

CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma

et al. 2018

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BackgroundPatients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenvironment. In this study, we examined whether the number of microvessels and the expression level of vascular endothelial growth factor (VEGF) in the primary tumor are correlated with the degree of lymph node metastasis (N-stage), tumor staging (T) and survival time in LSCC patients.MethodsTissue-Microarrays of 97 LSCC patients were analyzed using immunohistochemistry. The expression of VEGF was scored as intensity of staining (low vs high) and the number of CD31-positive vessels (median

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“…The prevalence of laryngeal carcinoma is increasing; it currently accounts for 1‒5% of all malignant tumors and 11‒22% of head and neck malignant tumors [ 2 , 3 ]. Further, tumor size, local invasion, spread into lymph nodes, and distant metastasis can affect the prognosis for laryngeal carcinoma [ 4 ]. Chemoradiotherapy is used to treat laryngeal carcinoma in its early stage, whereas surgery is widely used in its advanced stage, including total and partial laryngectomies [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Nurse-led telephone follow-up according to the revised nursing outcomes classification for laryngeal carcinoma surgery patients: a randomized controlled trial

et al. 2022

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Background This study used the revised nursing outcomes classification (NOC) outlined in our previous study, “Core nursing outcomes for otorhinolaryngology head-neck,” for telephone follow-up of patients who had laryngeal carcinoma surgery in China. This randomized controlled trial aimed to compare nurse-led telephone follow-up according to the revised NOC with traditional telephone follow-up. Methods A total of 100 postoperative patients were recruited from March 2018‒March 2020. Patients were randomly assigned to nurse-led telephone follow-up groups as either revised NOC follow-up (n = 51) or traditional follow-up (n = 49). The investigated outcomes included nursing outcomes, quality of life, and self-care abilities. Results The baseline characteristics of patients were well balanced. We noted that improvements in nursing outcomes in the intervention group were significantly better than for those in the control group (P = 0.018), primarily regarding psychosocial health (P < 0.001) and health knowledge and behavior (P < 0.001). Moreover, patient outcomes in the intervention group were associated with greater improvements in quality of life than those in the control group (P < 0.001), especially for social conditions (P < 0.001), emotional health (P < 0.001), functional status (P < 0.001), and additional attention (P = 0.001). Finally, compared with the control group, significant improvements were observed in self-care abilities in the intervention group (P = 0.002), mainly regarding general self-care abilities (P = 0.016) and development self-care abilities (P < 0.001). Conclusion This study found that nurse-led telephone follow-up according to the revised NOC improved nursing outcomes, quality of life, and self-care abilities. Trial registration: ChiCTR2100045941.

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Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced squamous cell carcinoma of the larynx

Abstract: Although vascular endothelial growth factor was expressed in a few cases, there was no correlation with the spread of cervical lymph metastases.

Cited by 6 publications

References 21 publications

Candidate Angiogenesis‐Related Biomarkers in Patients with Laryngeal Carcinoma (AngLaC): A Prospective Cohort Study

Candidate Angiogenesis‐Related Biomarkers in Patients with Laryngeal Carcinoma (AngLaC): A Prospective Cohort Study

CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma

Nurse-led telephone follow-up according to the revised nursing outcomes classification for laryngeal carcinoma surgery patients: a randomized controlled trial

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