Papillary thyroid carcinoma: does the association with Hashimoto's thyroiditis affect the clinicopathological characteristics of the disease?

Girardi, Fábio Muradás; Barra, Marinez Bizarro; Zettler, Cláudio Galleano

doi:10.1016/j.bjorl.2014.04.006

Cited by 39 publications

(47 citation statements)

References 30 publications

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“…Although it is not statistically significant, our study showed that, the TNM staging of PTC patients in HT group had a higher proportion of stage I than the PTC patients in non-HT group. These results were compatible with the literatüre and these results can be suggestive that the tumor's biological behavior is better in the case of HT or its due to the close follow-up of HT patients for thyroid disorders (3,6,9,14).…”

Section: Discussionsupporting

confidence: 90%

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Kutlutürk¹,

Ünal²,

Çetin³

2017

J Turgut Ozal Med Cent

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Aim: A positive correlation between Hashimoto's thyroiditis (HT) and papillary thyroid cancer (PTC) is determinated in studies based on histopathological examination of the thyroidectomy materials, but this correlation is not determinated in studies based on Fine Niddle Aspiration Biopsy (FNAB). In this study, the histopathologic results of bilateral total thyroidectomy (TT) specimens were studied for outcomes of PTC association with HT and its relationship with clinical and pathological prognostic factors. Material and Methods: Demographic data, thyroidectomy indications and pathology results of 568 patients with performed TT between April 2009 March 2016 were collected. PTC identified patients, were evaluated in terms of HT association. In these patients, the prognostic factors were evaluated according to coexistence of HT. Results: The average age of the patients was 48.9 years and M / F ratio was 1: 3.5. HT was detected in 36 patients and PTCin 121 patients by histopathological examinations. PTC incidence in HT group was higher than non-HT group. (p = 0.025). HT incidence in PTC group was higher than non-PTC group (p = 0.025).When compared in terms of demographic and prognostic data of PTC patiens,no statistically significant difference was detected between PTC with and without HT groups. Conclusion: PTC detection rate in patients with HT, who has indication for thyroidectomy is higher than non-HT patients. HT patients (especially female sex), should be followed closely, in terms of the development of malignant nodules.

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Section: Discussionsupporting

confidence: 90%

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Kutlutürk¹,

Ünal²,

Çetin³

2017

J Turgut Ozal Med Cent

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“…Lindsay et al (1955) first described an association of AIT and papillary thyroid carcinoma [8]. Several groups found a high incidence of AIT in papillary thyroid carcinoma up to 44 % [9,10]. Data of our group show an incidence of 21 % of AIT in thyroid carcinoma patients (Bouter et al, unpublished data).…”

supporting

confidence: 53%

What makes Lymphadenopathy in Patients with Autoimmune Thyroiditis Suspicious for Malignancy?

Bouter¹,

Meller²,

Meller³

et al. 2016

Exp Clin Endocrinol Diabetes Rep

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Lymphadenopathy in Robbins level II-IV and VI is common in autoimmune thyroiditis but the diagnostic strategy of a distinct lymphadenopathy exceeding the known features in autoimmune thyroiditis patients is unknown. The aim of this study was to determine how the extent of cervical lymphadenopathy in autoimmune thyroiditis affects the diagnostic management.The study comprises one index-patient with autoimmune thyroiditis and distinct suspicious lymphadenopathy in all cervical levels as well as retroclavicular. In addition 10 patients with autoimmune thyroiditis and distinct suspicious lymphadenopathy limited to level VI were evaluated.Findings of high resolution ultrasound, fine-needle aspiration cytology, serological testing and clonal analysis are reported here. Further diagnostics of the index-patient included histology, immunohistochemistry, bcl-2-expression analysis and PET/CT.The index-patient showed distinct lymphadenopathy in level I-VI and retroclavicular. Lymph nodes did not display any sonographic malignancy criteria. Molecular analysis and immunohistochemistry revealed monoclonal CD10- and CD20-positive, Bcl-2 expressing follicular B-cells confirming the diagnosis of a follicular B-cell Non-Hodgkin lymphoma.10 additional patients with limited lymphadenopathy showed typical features of autoimmune thyroiditis and lymph nodes did not display sonographic malignancy criteria in all cases. Further tests excluded lymph node malignancies.Extensive diagnostics in autoimmune thyroiditis and distinct cervical lymphadenopathy is crucial. Whereas limited lymphadenopathy in AIT was proven benign, extensive lymphadenopathy exceeding the known amount and/or spreading to retroclavicular/mediastinal compartments is suspicious for malignancy. Even in the absence of sonographic malignancy criteria further tests have to be performed.

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“…It is composed predominantly or almost entirely of follicles lined by cells showing nuclear features of papillary carcinoma. [2,15] In this study they constituted to 11.4% of cases. In the present study we have encountered some of the rare variants like tall cell and Warthin like variants.…”

Section: Discussionmentioning

confidence: 85%

A Study on Papillary Thyroid Carcinoma- Histopathological Variants and Patterns

Devi¹,

Prasanna²,

Venkatachalam³

2019

jemds

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BACKGROUND Papillary carcinoma is a frequently reported thyroid malignancy. Diagnosis is based on the microscopic architecture and the characteristic nuclear features such as nuclear clearing, grooves and pseudo inclusions which can be seen on routine haematoxylin and eosin stained sections. Many morphological variants of this entity have been reported in the literature, classical papillary thyroid carcinoma (PTC) being the most common variant. Follicular, solid, tall cell, columnar etc., are the other variants. Some of these variants cause diagnostic difficulties on histopathological examination and also they have varied prognostic implications. METHODS This is a retrospective descriptive study which included 44 cases of papillary thyroid carcinoma diagnosed on histopathology over a period of 3 years. RESULTS Classical PTC was the most common variant (52.3%), followed by papillary micro carcinoma (13.6%), follicular variant (11.4%), mixed type that had features of both papillary and follicular (9.1%), tall cell and solid variants (4.5% each); and encapsulated, Warthin-like variants (2.3% each). Associated Hashimoto's thyroiditis was seen in 20.4% cases (n=9/44). CONCLUSIONS Papillary thyroid carcinomas showed a female sex predilection. Though seen within a wide age range, they were more common in the third decade. Classical papillary thyroid carcinoma was the most common variant followed by micro papillary carcinoma and follicular carcinoma. Rare variants found in the study were tall cell and Warthin like variants. Nodular goitre and Hashimoto thyroiditis were the common lesions associated with PTC. Histological variations and patterns in papillary thyroid carcinoma have prognostic implications, so it is important to identify and report them whenever present.

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Papillary thyroid carcinoma: does the association with Hashimoto's thyroiditis affect the clinicopathological characteristics of the disease?

Abstract: A high proportion of papillary thyroid carcinoma cases are associated with Hashimoto's thyroiditis. There are associations among these cases with several histopathological factors already recognized for their prognostic value, which by themselves could impact outcomes.

Cited by 39 publications

References 30 publications

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

What makes Lymphadenopathy in Patients with Autoimmune Thyroiditis Suspicious for Malignancy?

A Study on Papillary Thyroid Carcinoma- Histopathological Variants and Patterns

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