2017
DOI: 10.1016/j.bjm.2017.04.001
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Abstract: Early diagnosis of tuberculosis is of major clinical importance. Among 4733 clinical specimens collected from 3363 patients and subjected to Ziehl–Neelsen microscopy, 4109 were inoculated onto Löwenstein–Jensen slants and 3139 in Bactec/9000MB. Polymerase Chain Reaction (PCR) was performed in 3139 specimens, whereas, a genotypic assay was directly applied in 93 Mycobacterium tuberculosis complex PCR-positive for isoniazid and rifampicin resistance detection specimens (GenoType MTBDRplus). Recovered M. tubercul… Show more

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Cited by 4 publications
(1 citation statement)
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“…As not all types of mutations that cause drug resistance have been identified, using molecular assays in conjunction with pDST could enable the rapid and accurate determination of drug susceptibility of MTB isolates, thereby facilitating timely initiation of appropriate anti-TB drug therapy [28]. In particular, the 100% concordance between DNA sequencing and QMAP results indicates that QMAP could detect all known, or at least, targeted DNA mutations associated with drug resistance.…”
Section: Discussionmentioning
confidence: 99%
“…As not all types of mutations that cause drug resistance have been identified, using molecular assays in conjunction with pDST could enable the rapid and accurate determination of drug susceptibility of MTB isolates, thereby facilitating timely initiation of appropriate anti-TB drug therapy [28]. In particular, the 100% concordance between DNA sequencing and QMAP results indicates that QMAP could detect all known, or at least, targeted DNA mutations associated with drug resistance.…”
Section: Discussionmentioning
confidence: 99%