Draft genome sequence of a multidrug-resistant beta-lactamase OXA-357-producing Acinetobacter pittii ST865 clinical isolate from China

Wang, Jianfeng; Chen, Yan; Wu, Liyan; Chen, Yu; Xu, Liqun

doi:10.1016/j.bjm.2016.10.020

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Whole-genome sequences of A. pittii have been reported in ST119, ST207 (strain TCM292), ST220 (strain YB-45), ST865 (strain TCM156), and several strains deposited in GenBank [ 44 , 53 , 56 , 57 ]. Whole-genome SNP phylogeny revealed that our XDRAP isolates showed that the A436 (ST63) isolate was closely related to the strain WCHAP100020 from China.…”

Section: Discussionmentioning

confidence: 99%

Genomic Characterization of Clinical Extensively Drug-Resistant Acinetobacter pittii Isolates

et al. 2021

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Carbapenem-resistant Acinetobacter pittii (CRAP) is a causative agent of nosocomial infections. This study aimed to characterize clinical isolates of CRAP from a tertiary hospital in Northeast Thailand. Six isolates were confirmed as extensively drug-resistant Acinetobacter pittii (XDRAP). The blaNDM-1 gene was detected in three isolates, whereas blaIMP-14 and blaIMP-1 were detected in the others. Multilocus sequence typing with the Pasteur scheme revealed ST220 in two isolates, ST744 in two isolates, and ST63 and ST396 for the remaining two isolates, respectively. Genomic characterization revealed that six XDRAP genes contained antimicrobial resistance genes: ST63 (A436) and ST396 (A1) contained 10 antimicrobial resistance genes, ST220 (A984 and A864) and ST744 (A56 and A273) contained 9 and 8 antimicrobial resistance genes, respectively. The single nucleotide polymorphism (SNP) phylogenetic tree revealed that the isolates A984 and A864 were closely related to A. pittii YB-45 (ST220) from China, while A436 was related to A. pittii WCHAP100020, also from China. A273 and A56 isolates (ST744) were clustered together; these isolates were closely related to strains 2014S07-126, AP43, and WCHAP005069, which were isolated from Taiwan and China. Strict implementation of infection control based upon the framework of epidemiological analyses is essential to prevent outbreaks and contain the spread of the pathogen. Continued surveillance and close monitoring with molecular epidemiological tools are needed.

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Section: Discussionmentioning

confidence: 99%

Genomic Characterization of Clinical Extensively Drug-Resistant Acinetobacter pittii Isolates

et al. 2021

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Exploring the resistome and virulome in major sequence types of Acinetobacter baumannii genomes: Correlations with genome divergence and sequence types

Banerjee,

Robinson,

Lahiri

et al. 2024

Infection, Genetics and Evolution

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Comparative genomic analysis of Acinetobacter spp. plasmids originating from clinical settings and environmental habitats

Salto

Tejerizo

Wibberg

et al. 2018

Sci Rep

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Bacteria belonging to the genus Acinetobacter have become of clinical importance over the last decade due to the development of a multi-resistant phenotype and their ability to survive under multiple environmental conditions. The development of these traits among Acinetobacter strains occurs frequently as a result of plasmid-mediated horizontal gene transfer. In this work, plasmids from nosocomial and environmental Acinetobacter spp. collections were separately sequenced and characterized. Assembly of the sequenced data resulted in 19 complete replicons in the nosocomial collection and 77 plasmid contigs in the environmental collection. Comparative genomic analysis showed that many of them had conserved backbones. Plasmid coding sequences corresponding to plasmid specific functions were bioinformatically and functionally analyzed. Replication initiation protein analysis revealed the predominance of the Rep_3 superfamily. The phylogenetic tree constructed from all Acinetobacter Rep_3 superfamily plasmids showed 16 intermingled clades originating from nosocomial and environmental habitats. Phylogenetic analysis of relaxase proteins revealed the presence of a new sub-clade named MOBQAci, composed exclusively of Acinetobacter relaxases. Functional analysis of proteins belonging to this group showed that they behaved differently when mobilized using helper plasmids belonging to different incompatibility groups.

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Draft genome sequence of a multidrug-resistant beta-lactamase OXA-357-producing Acinetobacter pittii ST865 clinical isolate from China

Cited by 4 publications

References 10 publications

Genomic Characterization of Clinical Extensively Drug-Resistant Acinetobacter pittii Isolates

Genomic Characterization of Clinical Extensively Drug-Resistant Acinetobacter pittii Isolates

Exploring the resistome and virulome in major sequence types of Acinetobacter baumannii genomes: Correlations with genome divergence and sequence types

Comparative genomic analysis of Acinetobacter spp. plasmids originating from clinical settings and environmental habitats

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