2016
DOI: 10.1016/j.bjm.2016.10.004
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Abstract: l-asparaginase (EC 3.5.1.1) is an enzyme that catalysis mainly the asparagine hydrolysis in l-aspartic acid and ammonium. This enzyme is presented in different organisms, such as microorganisms, vegetal, and some animals, including certain rodent's serum, but not unveiled in humans. It can be used as important chemotherapeutic agent for the treatment of a variety of lymphoproliferative disorders and lymphomas (particularly acute lymphoblastic leukemia (ALL) and Hodgkin's lymphoma), and has been a pivotal agent… Show more

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Cited by 160 publications
(96 citation statements)
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References 69 publications
(52 reference statements)
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“…It is produced by a large number of microorganisms that include Pseudomonas stutzeri 4 , Pseudomonas aerugenosa 5, and E. coli 6 . It is used for the treatment of acute lymphoblastic Leukemia, preliminary and advanced stages of cancer 7,8 so L-Asparaginase is a critical extracellular enzyme of medical importance as an anti-cancer agent and an anti-microbial agent. Asparaginase is commonly used in place of heat treatment of starchy food in the industry to reduce the formation of the acrylamide, which is suspected human carcinogenic 8, 9 .…”
Section: Quick Response Codementioning
confidence: 99%
“…It is produced by a large number of microorganisms that include Pseudomonas stutzeri 4 , Pseudomonas aerugenosa 5, and E. coli 6 . It is used for the treatment of acute lymphoblastic Leukemia, preliminary and advanced stages of cancer 7,8 so L-Asparaginase is a critical extracellular enzyme of medical importance as an anti-cancer agent and an anti-microbial agent. Asparaginase is commonly used in place of heat treatment of starchy food in the industry to reduce the formation of the acrylamide, which is suspected human carcinogenic 8, 9 .…”
Section: Quick Response Codementioning
confidence: 99%
“…It is used in the treatment of acute lymphoblastic leukemia, acute myeloid leukemia, and Hodgkin's lymphoma. [2] Lack of the enzyme affects nucleic acid synthesis which is the cause for apoptotic cell death of cancer cell. In the food industry, this enzyme decreases acrylamide levels in fried foods maintaining food security.…”
Section: R Ecombinantmentioning
confidence: 99%
“…However, the structural complexity, large size, and high susceptibility of the biomolecules make the manufacturing processes of biopharmaceuticals quite challenging . Among these, the biopharmaceutical l ‐asparaginase, l ‐asparagine amidohydrolase, EC.3.5.1.1 (ASNase), a therapeutic enzyme largely used in the treatment of childhood acute lymphoblastic leukemia (ALL), has been intensively studied . As other biopharmaceuticals, the high purity demands increases the ASNase high commercial price .…”
Section: Introductionmentioning
confidence: 99%
“…1 Among these, the biopharmaceutical L-asparaginase, L-asparagine amidohydrolase, EC.3.5.1.1 (ASNase), a therapeutic enzyme largely used in the treatment of childhood acute lymphoblastic leukemia (ALL), has been intensively studied. [2][3][4] As other biopharmaceuticals, the high purity demands increases the ASNase high commercial price. 5 The design of alternative and stabilizing downstream platforms is thus of upmost importance and fundamental in reducing the overall ASNase manufacturing costs.…”
Section: Introductionmentioning
confidence: 99%