2017
DOI: 10.1016/j.bjm.2016.08.002
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Abstract: Serratia marcescens is a Gram-negative rod intrinsically resistant to polymyxins and usually associated with wound, respiratory and urinary tract infections. The whole genome of the first GES-5-producing S. marcescens isolated from a Brazilian patient was sequenced using Ion Torrent PGM System. Besides blaGES-5, we were able to identify genes encoding for other β-lactamases, for aminoglycoside modifying enzymes and for an efflux pump to tetracyclines.

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Cited by 4 publications
(5 citation statements)
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“…The persistence of genes that confer resistance to carbapenems results due to the clonal dissemination of the isolates and via the dispersion of these genes through conjugative or mobile plasmids 8 , 9 , 10 , 11 . In this study, we detected five types of Incs which are described in the literature as being potentially responsible for the spread of bla KPC and bla NDM genes in K. pneumoniae isolates.…”
Section: Discussionmentioning
confidence: 99%
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“…The persistence of genes that confer resistance to carbapenems results due to the clonal dissemination of the isolates and via the dispersion of these genes through conjugative or mobile plasmids 8 , 9 , 10 , 11 . In this study, we detected five types of Incs which are described in the literature as being potentially responsible for the spread of bla KPC and bla NDM genes in K. pneumoniae isolates.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, resistance to carbapenems can occur due to the production of other enzymes, such as metallo-beta-lactamases, e.g., the New Delhi metallo-beta-lactamase-1 (NDM-1). Since its detection in 2008 in New Delhi, India 23 strains producing NDM-1 have been reported in many countries, including Brazil 6,8,9,24,25 . Considering the importance of knowing which resistance genes and plasmids are circulating among multi-drug resistant clinical isolates…”
Section: Introductionmentioning
confidence: 99%
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“…in clinical specimens: A prospective diagnostic accuracy study detected in S. marcescens (11,12). In addition, other types of carbapenemases, including S. marcescens enzymes, Serratia metallo-β-lactamase, Guiana extended-spectrum β-lactamase and Germany imipenemase, were detected in S. marcescens isolated in different regions (13)(14)(15)(16)(17)(18). The high hydrolytic efficiency of these carbapenemases when acting on carbapenem substrates combined with the natural resistance of S. marcescens to polymyxin B and polymyxin E (two restricted antibiotics used for multidrug-resistant bacteria infections), makes the treatment of S. marcescens infections challenging in the clinical setting (19).…”
Section: Evaluation Of Loop-mediated Isothermal Amplification Assaysmentioning
confidence: 99%