Identification and characterization of nontuberculous mycobacteria isolated from suspected pulmonary tuberculosis patients in eastern china from 2009 to 2019 using an identification array system

Zhu, Yanyan; Hua, Wenya; Liu, Zhengwei; Zhang, Mingwu; Wu, Beibei; Wang, Zhen; Chen, Jiazhen

doi:10.1016/j.bjid.2022.102346

Cited by 4 publications

(3 citation statements)

References 36 publications

(54 reference statements)

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“…These NTM species are frequently isolated from pulmonary specimens [5][6][7]. Other common species associated with human infections include Mycobacterium kansasii, Mycobacteroides chelonae and Mycobacterium fortuitum complex [3,6]. The clinical signs and symptoms of NTM infections vary with the site of infection, the species of NTM involved and the infected individual's immune status [8].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous species of NTM have been identified, with Mycobacterium avium-intracellulare complex (MAC) and Mycobacteroides abscessus complex (MABC) being the most common and clinically significant species. These NTM species are frequently isolated from pulmonary specimens [5][6][7]. Other common species associated with human infections include Mycobacterium kansasii, Mycobacteroides chelonae and Mycobacterium fortuitum complex [3,6].…”

Section: Introductionmentioning

confidence: 99%

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Five-year species distribution and antimicrobial susceptibility of non-tuberculous mycobacteria in Malaysia, 2018–2022

Mohamad Azranyi,

Aziz,

Ishak

et al. 2024

Journal of Medical Microbiology

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Introduction. Non-tuberculous Mycobacteria (NTM) is a group of mycobacteria distinct from the Mycobacterium tuberculosis complex. They can cause opportunistic infections, especially in immunocompromised individuals. Gap Statement. Over the last few years, there has been a growing concern regarding the distribution and antimicrobial resistance of NTM in Malaysia. however, a comprehensive study to fully grasp the NTM situation has yet to be conducted. Aim. This study aimed to investigate the species distribution and antimicrobial susceptibility patterns of NTM isolated from clinical samples in Malaysia from 2018 to 2022. Methodology. A retrospective analysis was conducted on NTM isolates obtained from various clinical specimens over a span of five years. The isolates were identified using phenotypic and molecular techniques, and antimicrobial susceptibility profiles for clinically significant isolates were determined using minimum inhibitory concentration. Results. The study revealed a diverse distribution of NTM species in Malaysia, with Mycobacteroides abscessus complex and Mycobacterium avium complex emerging as the most predominant. Furthermore, the antimicrobial susceptibility patterns showed varying degrees of resistance to commonly used antibiotics, highlighting the significance of treatment tailored to susceptibility testing results. Conclusion. This study provides valuable perspective into the epidemiology of NTM in Malaysia. The information gained from this study should prove useful for empirically treating serious NTM infections prior to species identification and the availability of antimicrobial susceptibility testing results.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Five-year species distribution and antimicrobial susceptibility of non-tuberculous mycobacteria in Malaysia, 2018–2022

Mohamad Azranyi,

Aziz,

Ishak

et al. 2024

Journal of Medical Microbiology

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“…Although three national TB epidemiological sampling surveys carried out in China in 1990, 2000 and 2010 reported the proportion of NTM among mycobacterial isolates, these NTM isolates were not identified to species. A few studies have reported NTM epidemiology mainly based on regional or local data (6)(7)(8)(9)(10)(11). Liu et al (12) reported the incidence of NTM in China from a national survey conducted in 2013.…”

Section: Introductionmentioning

confidence: 99%

Trends and Species Diversity of Non-tuberculous Mycobacteria Isolated From Respiratory Samples in Northern China, 2014–2021

Sun

Yan

Liao

et al. 2022

Front. Public Health

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BackgroundPulmonary non-tuberculous mycobacteria (NTM) infection has become a public health concern in China and around the world. The objective of this study was to describe the longitudinal changes in the frequency and diversity of NTM in northern China.MethodsWe retrospectively analyzed data on mycobacterium species in Beijing Chest Hospital from January 2014 to December 2021. The isolates were identified to species level by targeted DNA sequencing.ResultsAfter excluding duplicates, 1,755 NTM strains were analyzed, which were from 27 provinces in China over 8 years. Among all mycobacteria, the proportion of NTM increased each year, from 4.24% in 2014 to 12.68% in 2021. Overall, 39 different NTM species were identified, including 23 slow growing mycobacteria (SGM) and 16 rapid growing mycobacteria (RGM). The most common species were M. intracellulare (51.62%), M. abscessus (22.22%), M. kansasii (8.32%), M. avium (7.75%) and M. fortuitum (2.05%). The number of NTM species identified also increased each year from 9 in 2014 to 26 in 2021. Most species showed stable isolation rates over the years; however, the proportion of M. avium increased from 3.85 to 10.42% during the study period. Besides, 81 non-mycobacteria strains, including Gordonia (21 isolates), Nocardia (19 isolates) and Tsukamurella (17 isolates), etc., were also discovered.ConclusionThe proportion of NTM and species diversity increased considerably in northern China from 2014 to 2021. M. intracellulare was the most common NTM isolated among respiratory specimens, followed by M. abscessus and M. kansasii. Rare NTM species and non-mycobacteria pathogens also need attention.

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Global Epidemiology of Nontuberculous Mycobacterial Pulmonary Disease

Prevots,

Marshall,

Wagner

et al. 2023

Clinics in Chest Medicine

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Identification and characterization of nontuberculous mycobacteria isolated from suspected pulmonary tuberculosis patients in eastern china from 2009 to 2019 using an identification array system

Cited by 4 publications

References 36 publications

Five-year species distribution and antimicrobial susceptibility of non-tuberculous mycobacteria in Malaysia, 2018–2022

Five-year species distribution and antimicrobial susceptibility of non-tuberculous mycobacteria in Malaysia, 2018–2022

Trends and Species Diversity of Non-tuberculous Mycobacteria Isolated From Respiratory Samples in Northern China, 2014–2021

Global Epidemiology of Nontuberculous Mycobacterial Pulmonary Disease

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