Evaluation of a strategy for identification of hepatitis C virus carriers in outpatient and emergency units: contribution to the microelimination of hepatitis C in Brazil

Gardona, Rodrigo Galvão Bueno; Appel, Flávia; Ercolin, Samara; Carvalho-Filho, Roberto José de; Barbosa, Dulce Aparecida; Ferraz, M.L.G.

doi:10.1016/j.bjid.2021.101546

Cited by 2 publications

(2 citation statements)

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“…It is also worth highlighting that there was an increasing trend in individuals under 5 years of age and in those over 60 years (APC 18.5 and 15.0, respectively). Previous studies have demonstrated a higher prevalence of HCV in young people and in adults over 45 years old [ 2 , 13 , 20 , 25 ]. The main explanation for the increased incidence of HCV in these age groups involves changes in the mechanisms of disease transmission over the years.…”

Section: Discussionmentioning

confidence: 99%

A time series analysis of detection and mortality of hepatitis C in Brazil, 2008–2018

et al. 2022

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Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030. In Brazil, efforts have been undertaken to achieve this goal; there are, however, great challenges. It is important to understand the disease profile in different regions of the country in order to design strategies to fight the disease nationwide. The objective of this study was to analyse the time trend of the incidence and mortality of hepatitis C in Brazil during the period from 2008 to 2018 according to sociodemographic and clinical characteristics. Methods All newly diagnosed cases of hepatitis C reported between 2008 and 2018, in all regions of Brazil, were included. The indicators were obtained from the databases of the Brazilian Ministry of Health. For the time series analysis, a joinpoint regression model was used. Results Between 2008 and 2018, 136,759 newly diagnosed cases of hepatitis C were reported considering anti-HCV and HCV RNA positivity, and 271,624 newly diagnosed cases were reported considering one or another positive test. The majority of the records were concentrated in the Southeast (61%) and South (26.2%) Regions. The joinpoint regression model indicated an increasing trend in the detection rate of hepatitis C in Brazil, but there was a decreasing trend in the mortality rate during the period analysed. Conclusions Differences were observed in the time trend of hepatitis C and in the sociodemographic and clinical characteristics in different regions of Brazil. These data can provide support to design strategies for the elimination of hepatitis C in Brazil, according to regional particularities.

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Section: Discussionmentioning

confidence: 99%

A time series analysis of detection and mortality of hepatitis C in Brazil, 2008–2018

et al. 2022

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“…Hepatitis C virus (HCV) determination is important for the treatment of chronic hepatitis C. − Quantitative reverse transcription–PCR (RT–qPCR) has been considered to be an efficient approach for quantifying HCV RNA in blood. A μTASWako g1 fully automated genetic analyzer could be used to prepare samples and to extract RNA in human clinical samples, and a microfluidic RT–qPCR–CE system was developed to achieve RNA amplification and detection with improved assay performance and reduced costs .…”

Section: Microscale Systems “See” In Virusesmentioning

confidence: 99%