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Cited by 65 publications
(61 citation statements)
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References 6 publications
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“…In this study Ivermectin is very effective in preventing corona virus infection in health care or household contacts of COVID 19 patients group V (2%) compared to non Ivermectin group VI (10%). Physicians have directed the usage of ivermectin in a few synchronous trials in many countries [32], and announced that patients' viral loads started declining very quickly after Ivermectin administering. We noticed that it has surprised physicians in clinical trials in many countries.…”
Section: Discussionmentioning
confidence: 99%
“…In this study Ivermectin is very effective in preventing corona virus infection in health care or household contacts of COVID 19 patients group V (2%) compared to non Ivermectin group VI (10%). Physicians have directed the usage of ivermectin in a few synchronous trials in many countries [32], and announced that patients' viral loads started declining very quickly after Ivermectin administering. We noticed that it has surprised physicians in clinical trials in many countries.…”
Section: Discussionmentioning
confidence: 99%
“…In this study Ivermectin is very effective in preventing corona virus infection in health care or household contacts of COVID 19 patients group V (2%) compared to non Ivermectin group VI (10%). Physicians have directed the usage of ivermectin in a few synchronous trials in many countries [32], and announced that patients' viral loads started declining very quickly after Ivermectin administration. We noticed that it has surprised physicians in clinical trials in many countries.…”
Section: Discussionmentioning
confidence: 99%
“…Chloroquine -Interferes with ACE2 ligands and receptors, decreasing the penetration of the virus into the cell, in addition, it changes the pH of the endosome, making it difficult to release viral RNA in the cell's cytoplasm; Azithromycin -Reduces the number of microorganisms in the alveolus and maintains the integrity of tight junctions, reinforcing the virus barrier; Anti-inflammatory drugs -Reduce the inflammatory process by decreasing the release of cytokines, Ivermectin -Inhibits the integrase protein and importin α/ÎČ1 (IMPα/ÎČ1) heterodimer that promote the entry of viral proteins in the cell nucleus; Convalescent plasma -Immunoglobulins directly fight the virus; Anticoagulant drugs-Interact with antithrombin reducing the thrombotic process; Antivirals (Remdesivir) -Inhibit the RNA-dependent RNA polymerase (RdRp) preventing the self-replication of viral RNA; Zinc -inhibits RNA-dependent RNA polymerase (RdRp) preventing self-replication of viral RNA. with drugs that have shown in vitro antiviral activity (67), which includes chloroquine, hydroxychloroquine and ivermectin. However, randomized clinical trials have not demonstrated a prophylactic effect with reduced hospitalization among adults with mild COVID-19 that have been treated with hydroxychloroquine.…”
Section: Discussionmentioning
confidence: 99%