2018
DOI: 10.1016/j.bjid.2017.10.005
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Abstract: The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory C… Show more

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Cited by 26 publications
(16 citation statements)
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“…In our study all 38 tested isolates have shown that sensitive to voriconazole with the ECV ≤ 2 µg/ml. Many supportive studies have shown that A. flavus to be sensitive to voriconazole, like Denardi et al and Mahdavi-Omran et al which have reported MIC GM values 0.871 and 0.27 µg/ml respectively (7,11). Moreover, in a study by Borman et al only 0.7% of A. flavus isolates were resistant to voriconazole (10) whereas all tested isolates by Varotto et al were sensitive to voriconazole (35).…”
Section: Discussionmentioning
confidence: 96%
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“…In our study all 38 tested isolates have shown that sensitive to voriconazole with the ECV ≤ 2 µg/ml. Many supportive studies have shown that A. flavus to be sensitive to voriconazole, like Denardi et al and Mahdavi-Omran et al which have reported MIC GM values 0.871 and 0.27 µg/ml respectively (7,11). Moreover, in a study by Borman et al only 0.7% of A. flavus isolates were resistant to voriconazole (10) whereas all tested isolates by Varotto et al were sensitive to voriconazole (35).…”
Section: Discussionmentioning
confidence: 96%
“…Echinocandin resistance is uncommon among A. (11,12,28). They found that all isolates had MEC 90 lower than presented epidemiologic cutoff values.…”
Section: Discussionmentioning
confidence: 98%
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“…Also, other authors have reported differences of Aspergillus spp. susceptibility to echinocandins (Denardi et al 2018).…”
Section: Introductionmentioning
confidence: 99%
“…Environmental isolates of A. fumigatus and A. flavus have demonstrated azole-resistance which is a direct consequence of azole and benzimidazole pesticide exposure [14,15].…”
Section: Introductionmentioning
confidence: 99%