Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China

Abstract

This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections. In this retrospective cohort study, 257 older patients with bacterial infection were divided into two groups: a statin group, those who had received statin therapy for ≥1 month before admission and continued receiving statin during hospitalization; and a non-statin group, those who had never received statin or used statin for <1 month prior to admission. A multivariate logistic regression analysis was performed to identify risk and protective factors for severe sepsis. A significantly lower incidence of organ dysfunction was found in the statin group, as compared with the non-statin group (13.3% vs 31.1%, respectively; p=0.002), corresponding to adjusted rates ratio of 0.32 (95% confidence interval [CI], 0.13-0.75; p=0.009). No significant difference was found between statin and non-statin groups in 30-day sepsis-related mortality (4.4% vs 10.2%, respectively; p=0.109), incidence of intensive care unit admission (13.3% vs 16.8%, respectively; p=0.469), or length of hospital stay (20.5 vs 25.9 days, respectively; p=0.61). Statins significantly reduced the development of sepsis and infection-related organ dysfunction in hospitalized older Chinese patients but did not reduce 30-day mortality, ICU admission incidence, or length of hospital stay.

Statin use and Vital Organ Failure in Patients With Asthma–Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study

“…Statins may be beneficial in the case of acute hepatic failure, renal failure, (Gupta et al, 2007) and heart failure. Statins significantly reduced the development of sepsis and infection-related organ dysfunction in older patients in hospitals; however, it did not reduce intensive care unit (ICU) admission incidence with respiratory failure, supporting our findings (Gui et al, 2017).…”

Deep Venous Thrombosis and Risk of Consequent Sepsis Event: A Retrospective Nationwide Population-Based Cohort Study

“…In addition, this study result showed the protective effect of hyperlipidemia against sepsis, which could be explained as the statins prescriptions for hyperlipidemia patients. Previous studies have demonstrated a similar correlation that statins use was associated with a lower risk of developing sepsis [42][43][44].…”

Statins improve the long-term prognosis in patients who have survived sepsis

“…Statins significantly reduced the development of sepsis and infection-related organ dysfunction in hospitalized older Chinese patients, but did not reduce 30-day mortality, ICU admission incidence, or length of hospital stay. [18] According to the results by Lee et al, preadmission simvastatin, atorvastatin, and rosuvastatin were associate with a decreased 30-day mortality of 28%, 22%, and 13% compared with nonstatin users, respectively, in patients of sepsis. [14] This nation-scale cohort study skipped the previous non-resolved controversy, “effect of statins prior to or during the course of sepsis and the associated hospital outcomes”, and thus provided a new perspective program in post-sepsis care.…”