Serological survey of Chikungunya virus in Ilorin Metropolis, Nigeria

Kolawole, Olatunji Matthew; Bello, Kizito Eneye; Seriki, A; Irekeola, Ahmad Adebayo

doi:10.1016/j.bjid.2016.12.007

Cited by 8 publications

(8 citation statements)

References 3 publications

(4 reference statements)

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“…Overall, the seroprevalence of prior DENV infection was high in the study areas. These rates were consistent with previous studies conducted in Nigeria [15,19] with seroprevalence ranging from 32.1 to 67.7% in our study areas or study year. While we acknowledge the limitations of the broad antibody within the genera Flavivirus and Alphavirus, the serological assays used in the current study were based on agent-specific diagnostic antigens derived from dengue and chikungunya viruses.…”

Section: Discussionsupporting

confidence: 93%

A Retrospective Study of the Seroprevalence of Dengue Virus and Chikungunya Virus Exposures in Nigeria, 2010–2018

et al. 2022

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Arboviruses are important public health threats in many regions of the world. Nigeria has experienced outbreaks of arboviruses over the past decades, leading to concerns of widespread endemicity, which are frequently misdiagnosed. This study aimed to determine the seroprevalence of dengue virus (DENV) (a flavivirus) and chikungunya virus (CHIKV) (an alphavirus) infections in three major population centers of Nigeria. A convenience sample of 701 sera was collected from both healthy and febrile participants between August 2010 and March 2018. Sera were tested for prior exposure to CHIKV virus and DENV using indirect IgG ELISA. Results showed that 54.1% (379/701) of participants were seropositive for anti-DENV antibodies, 41.3% (290/701) were seropositive for anti-CHIKV antibodies, and 20.1% (141/701) had previous exposure to both. The seropositivity for prior CHIKV exposure and prior exposure to DENV and CHIKV was significantly associated with age (CHIKV: OR = 2.7 (95% CI: 1.7–4.3); DENV and CHIKV: OR = 2.2 (95% CI: 1.2–4.0) for adults compared to participants under 18 years old). Overall, the high seropositivity across all age groups suggests that arboviral infections are prevalent in Nigeria and indicates that surveillance and further epidemiological studies are required to determine the true burden of these infections and the spectrum of diseases associated with these exposures.

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Section: Discussionsupporting

confidence: 93%

A Retrospective Study of the Seroprevalence of Dengue Virus and Chikungunya Virus Exposures in Nigeria, 2010–2018

et al. 2022

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“…IgM was positive in 10.39% (n = 27/260) and IgG in 20.76% (n = 54/260). A similar study in Nigeria and Benin reported 13% and 36.1% of anti-Chikungunya IgG antibodies respectively compared to 20.76% in Ghana [20, 21]. Anti-Chikungunya IgM antibodies of 10.39% in our study may suggest recent infections, notwithstanding, subclinical or possibly apparent that might have been missed and undiagnosed or treated as any common endemic ailment.…”

Section: Discussionsupporting

confidence: 58%

Arbovirus circulation among febrile patients at the greater Accra Regional Hospital, Ghana

et al. 2019

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Objective Arboviruses, Dengue and Chikungunya have become major international public health concerns due to their epidemics and introduction in new areas. In Ghana, little is known is about Dengue and Chikungunya viruses though the country has been listed as part of the 34 countries in which the viruses are endemic. This has been attributed partly to the lack of diagnostic tools for these viruses in several health facilities and institutions across the country. The purpose of this study was to detect and characterize these viral pathogens among febrile patients in Accra Ghana. Results This hospital-based cross-sectional study enrolled 260 suspected Dengue and/or Chikungunya febrile patients who submitted their clinical specimens of serum. Out of the total number tested with both molecular and serological tools, Chikungunya and Dengue specific total antibodies were detected from 72 (27.69%) and 180 (69.23%) respectively. None of the participants tested positive for Dengue and Chikungunya by reverse transcription-polymerase chain reaction (RT-PCR) and with the Dengue-specific NS1 antigen strip kits. Our findings suggested that Dengue and Chikungunya viruses may be circulating but are being missed among febrile patients. Differential diagnosis work-up in febrile patients should be made to include Dengue and Chikungunya infections.

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“…In our previous studies we established the presence of arboviruses capable of causing human diseases and belonging to three of the four virus families already highlighted [12,13,14,15,16]. As our findings suggest, DENV is highly prevalent in Nigeria [13].…”

Section: Introductionmentioning

confidence: 52%

The Neglect and Fast Spread of Some Arboviruses: A Note for Healthcare Providers in Nigeria

et al. 2018

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Arboviruses are distributed worldwide and constitute significant health burden globally. Outbreaks of arboviruses have been reported in Africa and beyond. In Nigeria, like in many other countries, arbovirus infections are more often than not neglected. As the early clinical features of arbovirus infections are generally nonspecific, most healthcare providers mistake them for other diseases. Outbreaks have been reported in Africa and beyond. The consequence of missed diagnosis of diseases cannot be overstated. In this review, some epidemiological data, classical syndromes, and risk factors for five human arboviruses (yellow fever YF, dengue DENV, chikungunya CHIKV, Rift Valley fever RVF, and West Nile virus WNV) found in Nigeria are presented. Health practitioners should ensure in-depth analysis rather than a superficial diagnosis of diseases before declaring a course of treatment.

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Serological survey of Chikungunya virus in Ilorin Metropolis, Nigeria

Cited by 8 publications

References 3 publications

A Retrospective Study of the Seroprevalence of Dengue Virus and Chikungunya Virus Exposures in Nigeria, 2010–2018

A Retrospective Study of the Seroprevalence of Dengue Virus and Chikungunya Virus Exposures in Nigeria, 2010–2018

Arbovirus circulation among febrile patients at the greater Accra Regional Hospital, Ghana

The Neglect and Fast Spread of Some Arboviruses: A Note for Healthcare Providers in Nigeria

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