First case of infection by metallo-β-lactamase-producing Pseudomonas aeruginosa in Mato Grosso do Sul, Brazil

Ferreira, Kalinca Miranda; Rodrigues, Ana Claudia de Souza; Watanabe, Ana Carolina; Ferreira, Yanara Miranda; Chang, Marilene Rodrigues

doi:10.1016/j.bjid.2016.12.005

Cited by 2 publications

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References 5 publications

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“…Among a variety of gram-negative bacilli, the resistance genes are likely to become highy disseminated. It is essential to rapidly detect Metallo-β-lactamase (MBL)-positive gram-negative bacilli in order to control infection and to prevent their spreading [5,6].…”

Section: Introductionmentioning

confidence: 99%

Karbapenem dirençli Pseudomonas ve Acinetobacter türlerinde MBL üretiminin saptanması ve risk faktörlerinin değerlendirilmesi.

Deniz

Baykam

2023

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Purpose: To investigate the frequency of MBLs in Pseudomonas and Acinetobacter species with E-test, to determine the risk factors and to evaluate the demographic and clinical features of infected patients. Materials and methods: Imipenem or meropenem resistance of Pseudomonas and Acinetobacter isolated from several clinical samples with conventional methods were evaluated with imipenem EDTA E-test and the presence of Metallo-β-lactameses MBL was examined. Several isolates were screened for VIM-1, VIM-2, IMP-1, and IMP-2 with a PCR test. Results: Of 46 carbapenem resistant Acinetobacter isolates, 41 (89%), as well as of 19 carbapenem resistant Pseudomonas isolates, 5 (26%) had MBL positivity with imipenem-EDTA E-test. A history of Intensive Care Unit stay, mechanical ventilation and cephalosporin use were found to be significant risk factors with respect to MBL production. Conclusion: Detection of MBL production in Acinetobacter and Pseudomonas species especially in ICU patients is of prime importance to control infection rapidly and effectively, which contribute to prevention of outbreaks.

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Section: Introductionmentioning

confidence: 99%