Disseminated cutaneous leishmaniasis: ulcerovegetative and ulcero-crusted lesions

Sgarbi, Isabela Martins; Santos, Flávia da Silva Domingos; Monteiro, Veridiana Elisa; Fonseca, Sílvia Nunes Szente; Filho, Fred Bernardes

doi:10.1016/j.bjid.2016.10.014

Cited by 3 publications

(2 citation statements)

References 3 publications

(3 reference statements)

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“…The American tegumentary leishmaniasis (ATL) is caused predominantly by L. (V.) braziliensis, a parasite that is associated with different clinical forms of the disease as cutaneous, mucosal and disseminated cutaneous leishmaniasis (DL). 1,2 The cutaneous leishmaniasis (CL) is the most common presentation of the disease occurring in over 90% of the cases and is characterized by a well-limited skin ulcer with raised borders. Approximately 3% of CL patients develop concomitantly or months and sometimes years after the cutaneous disease, mucosal leishmaniasis (ML) that affect primarily the nasal mucosa.…”

Section: Introductionmentioning

confidence: 99%

Leishmania braziliensis isolated from disseminated leishmaniasis patients downmodulate neutrophil function

Cardoso

Bezerra

Medina

et al. 2019

Parasite Immunology

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Summary Aims The polymorphism observed in Leishmania braziliensis is associated with different clinical forms of leishmaniasis. Neutrophils ( PMN s) participate in the pathogenesis of leishmania infection, and here, we evaluate neutrophil function after infection with isolates of L. braziliensis from cutaneous leishmaniasis ( CL ) or disseminated leishmaniasis ( DL ) patients. Methods and results Neutrophils from 30 healthy subjects ( HS ) were infected with isolates of L . ( V .) braziliensis obtained from three CL and three DL patients. They were infected at the ratio of 3:1 parasites per neutrophil, and leishmania uptake was evaluated by microscopy. The neutrophil activation markers and oxidative burst by expression of dihidrorhodamine ( DHR ) were evaluated by flow cytometry and cytokine production by ELISA . The frequency of infected cells and the number of amastigotes were higher in neutrophils infected with CL isolates compared to DL isolates ( P < 0.05). The DHR and CD 66b expression after infection with DL isolate was lower than with CL isolates. There was no difference regarding chemokine production. Conclusion The L. (V.) braziliensis isolates of DL induced lower respiratory burst and neutrophils activation markers compared with CL isolates which may contribute to parasite survival and dissemination in DL patients.

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Section: Introductionmentioning

confidence: 99%

Leishmania braziliensis isolated from disseminated leishmaniasis patients downmodulate neutrophil function

Cardoso

Bezerra

Medina

et al. 2019

Parasite Immunology

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“…Good therapeutic response to pentavalent antimonial and other drugs of choice for the treatment of ACL was observed. [13][14][15][16] When disseminated leishmaniasis is caused by L. (L.) amazonensis, a reduced number of primary lesions (1-3) with an erythematous infiltrated plaque appearance are observed. The spread to other anatomical sites is late, taking on average 6-12 months, producing few metastatic lesions.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Atypical Cutaneous Leishmaniasis in a Patient with Mixed Leishmania guyanensis and Leishmania amazonensis Infection

Gosch

Resende

Amorim³

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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The disseminated form of leishmaniasis is a serious and rare disease, being diagnosed in 2% of the cutaneous cases registered per year in Brazil. The main characteristic is the appearance of multiple pleomorphic lesions on the cutaneous surface. A 68-year-old male from the rural area of Tocantins, Brazil, presented atypical disseminated cutaneous leishmaniasis (ACL). The clinical course and histopathological and immunological findings presented a mixed pattern that hindered diagnosis and therapeutic management. Molecular typing revealed a mixed infection with and. Molecular identification of the agents responsible for ACL is important for adequate therapeutic planning, minimizing the possibility of sequellae that impact the quality of life of the patient.

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American Tegumentary Leishmaniasis

Filho¹,

Queiroz

Nery

2018

The Journal of Emergency Medicine

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Disseminated cutaneous leishmaniasis: ulcerovegetative and ulcero-crusted lesions

Cited by 3 publications

References 3 publications

Leishmania braziliensis isolated from disseminated leishmaniasis patients downmodulate neutrophil function

Leishmania braziliensis isolated from disseminated leishmaniasis patients downmodulate neutrophil function

Case Report: Atypical Cutaneous Leishmaniasis in a Patient with Mixed Leishmania guyanensis and Leishmania amazonensis Infection

American Tegumentary Leishmaniasis

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