Early-onset neonatal sepsis by Group B Streptococcus in a Brazilian public hospital

Barbosa, Nayara Gonçalves; Reis, Heloísio dos; Mantese, Orlando César; Mussi-Pinhata, Marisa Márcia; Abdallah, Vânia Olivetti Steffen; Filho, Paulo Pinto Gontijo

doi:10.1016/j.bjid.2016.07.013

Cited by 6 publications

(8 citation statements)

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“…One hundred thirty-five articles (reporting data from 57 countries) met our inclusion criteria (search strategy of study selection in Figure 2 ). Of these, 90 reported incidence [ 22–96 ], (EOGBS: 74 studies; LOGBS: 33 studies), 64 reported CFR [ 22–27 , 30 , 34 , 37 , 38 , 41–43 , 46 , 49–57 , 59 , 61 , 63 , 68 , 70 , 71 , 73–75 , 78–81 , 84 , 89 , 90 , 92 , 95–111 ], and 45 reported serotype data [ 22–25 , 31 , 42 , 47 , 50 , 55 , 61 , 63 , 66 , 70 , 73 , 78 , 81 , 84 , 112–138 ]. (The full list of articles included in this review is available in Supplementary Table 3.)…”

Section: Resultsmentioning

confidence: 99%

Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses

Madrid

Seale

Kohli-Lynch

et al. 2017

Clinical Infectious Diseases

299

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BackgroundGroup B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasive GBS disease and the associated serotypes, updating previous estimates.MethodsWe conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data regarding invasive GBS disease in infants aged 0–89 days. We conducted random-effects meta-analyses of incidence, case fatality risk (CFR), and serotype prevalence.ResultsWe identified 135 studies with data on incidence (n = 90), CFR (n = 64), or serotype (n = 45). The pooled incidence of invasive GBS disease in infants was 0.49 per 1000 live births (95% confidence interval [CI], .43–.56), and was highest in Africa (1.12) and lowest in Asia (0.30). Early-onset disease incidence was 0.41 (95% CI, .36–.47); late-onset disease incidence was 0.26 (95% CI, .21–.30). CFR was 8.4% (95% CI, 6.6%–10.2%). Serotype III (61.5%) dominated, with 97% of cases caused by serotypes Ia, Ib, II, III, and V.ConclusionsThe incidence of infant GBS disease remains high in some regions, particularly Africa. We likely underestimated incidence in some contexts, due to limitations in case ascertainment and specimen collection and processing. Burden in Asia requires further investigation.

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Section: Resultsmentioning

confidence: 99%

Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses

Madrid

Seale

Kohli-Lynch

et al. 2017

Clinical Infectious Diseases

299

301

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“…In human specimens, including non-pregnant women, serotype Ia has been the most frequent in recent years [57,58]. The global data from serotyping prevalence also reports Ia, Ib, II, III, and Vas the most prevalent serotypes in pregnant women in all continents in reports published between 1997 and 2015 [60] (Fig. 2).…”

Section: Serotypesmentioning

confidence: 87%

“…The mothers either were not screened for GBS or, despite a positive GBS culture, the result was not delivered in time for antibiotic prophylaxis. According to Barbosa et al, these results not only reinforce the need for GBS screening but also demand the development of a faster diagnosis method [60].…”

Section: Gbs Neonatal Sepsismentioning

confidence: 95%

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Streptococcus agalactiae in pregnant women in Brazil: prevalence, serotypes, and antibiotic resistance

et al. 2019

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Brazilian data for maternal GBS colonization shows different prevalence rates. This conflicting data may be related to the absence of an official recommendation from the Federal Brazilian Health Authorities describing guidelines and protocols to perform GBS screening in pregnant women, in both public and private clinics. In the present review, we evaluated published reports addressing the prevalence of GBS in different regions of the country, methods used, and, when available, information regarding antibiotic resistance and serological typing of clinical isolates. According to this review, GBS prevalence in pregnant women in Brazil ranged from 4.2 to 28.4%, in the last 10 years. Serotype Ia was the most prevalent. The highest antibiotic resistance rates were found for tetarcycline, although its use to treat GBS infections is not common. Our results also show high resistance rates to clindamycin and erythromycin, which are commonly used as an alternative to penicillin in GBS infecctions. The increased antibiotic resistance, variations in serotype distribution, and high GBS prevalences need to be further investigated. Based on the present situation, recommendations regarding GBS surveillance in the country were raised and may improve our strategies for preventing neonatal infections.

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“…Studies in Malawi [19], Finland [20], Sweden [21], England [22], United States [23], Zimbabwe [18], Gambia [24], Egypt [25] and in Brazil [26] have shown variations in serotype distribution around the world. This study therefore sought to determine the prevalence of GBS and capsular type distribution of isolates colonising pregnant women in Namibia and South Africa.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and capsular type distribution of Streptococcus agalactiae isolated from pregnant women in Namibia and South Africa

et al. 2019

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Background Streptococcus agalactiae or Group B Streptococcus (GBS) is the leading cause of neonatal morbidity and mortality resulting in septicaemia, bacteraemia and meningitis. Long term problems in children range from loss of hearing to mental retardation. While Intrapartum Antibiotic Prophylaxis (IAP) has reduced the incidence of S. agalactiae infection, it still remains the leading cause of disease in neonates. GBS has ten capsular types whose distribution varies across the world. Therefore, this study sought to determine the prevalence of GBS in Namibia and South Africa amongst pregnant women between 35 and 37 weeks gestation and elucidate the capsular types. Methods Lower vaginal and rectal swabs were collected from pregnant women between 35 and 37 weeks gestation. Five hundred and thirty pregnant women were recruited into the study in Windhoek, Namibia while one hundred pregnant women were recruited in the Eastern Cape, South Africa. The swabs were cultured on 5% sheep blood agar (Biomerieux, New Jersey, USA) for isolation of GBS. Presumptive isolates were confirmed using both the Vitek (2) and molecular techniques targeting the scp B gene. Capsular typing was performed in a multiplex PCR with capsular specific primer pairs. Results The prevalence of GBS in Namibia was 13.6 and 37% in South Africa respectively. In both countries most women were dually colonised with GBS. Capsular types II, III and V were the most prevalent. Conclusions The prevalence of GBS in Namibia was lower than in South Africa in this study. The prevalence in both countries was not different from those reported in other African countries and around the world. The predominant capsular types in this study are the ones commonly associated with adverse maternal outcomes.

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Early-onset neonatal sepsis by Group B Streptococcus in a Brazilian public hospital

Cited by 6 publications

References 4 publications

Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses

Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses

Streptococcus agalactiae in pregnant women in Brazil: prevalence, serotypes, and antibiotic resistance

Prevalence and capsular type distribution of Streptococcus agalactiae isolated from pregnant women in Namibia and South Africa

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