Hepatitis E virus seroprevalence among schistosomiasis patients in Northeastern Brazil

Passos-Castilho, Ana Maria; Sena, Anne de; Domingues, Ana Lúcia Coutinho; Lopes, Edmundo Pessoa; Medeiros, Tibério Batista de; Granato, Celso; Ferraz, M.L.G.

doi:10.1016/j.bjid.2016.03.001

Cited by 14 publications

(5 citation statements)

References 27 publications

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“…The prevalence is the same with the prevalence recorded in United States [10]. However, it is lower than a prevalence of 22.5% in Rural Bangladesh [8], 14.3% in Austria [2], 5.38% in Italy [4], 5.8% in Ghana [11] 18.8% among schistosomiasis patients in Northeastern Brazil [12]. It is higher than a 2.6% prevalence recorded at Switzerland [13].…”

Section: Discussionsupporting

confidence: 65%

Human Hepatitis E Virus among Apparently Healthy Individuals in Ogbomoso, South-Western Nigeria

Oloke

2017

JHVRV

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This study was undertaken to determine the seroprevalence, and associated risk factors, of hepatitis E virus. A total of 186 consented apparently healthy individuals were recruited. Interviewer-administered questionnaire was used to obtain the socio-demographic information from the individuals. Blood samples were collected and analyzed for anti-HEV using third generation enzyme-linked immunosorbent assay (ELISA). Samples were collected over a period of 10 months (December 2014 -September 2015. Results obtained were analyzed using Statistical Package for Social Sciences (SPSS) version 20.0 statistical software; Chi-square (χ 2 ) test was utilized to assess the association between the sociodemographic variables and HEV status while Logistic regression was done to determine the strength of association between the potential risk factors and HEV status (statistical significance was set at P ˂ 0.05). The overall anti-HEV prevalence was 2.7% (5/186). The highest seroprevalence was in the age range 15-25 (4.1%) years. Males had higher prevalence (3.2%). None of the sociodemographic status and potential risk factors were significantly associated with HEV infection (P ˃ 0.05). Preventive public health measures should be maintained among individuals and communities. Data suggest further research with larger population as HEV remains an under-recognized public health challenge.

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Section: Discussionsupporting

confidence: 65%

Human Hepatitis E Virus among Apparently Healthy Individuals in Ogbomoso, South-Western Nigeria

Oloke

2017

JHVRV

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“…A 10‐year gap in knowledge followed, until 2011, when studies from Argentina, Bolivia, Brazil and Colombia, reported respective HEV prevalences . This wave of studies followed the global reports of chronic hepatitis E virus infection by HEV‐3 in immunosuppressed individuals, especially those with solid organ transplantation as well as the reports of extra‐hepatic manifestations of HEV.…”

Section: Detection Of Hev In Humans In South Americamentioning

confidence: 99%

Hepatitis E virus in South America: The current scenario

Pisano

Martinez‐Wassaf²,

Mirazo

et al. 2018

Liver International

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Hepatitis E virus (HEV) is one of the most frequent causes of acute viral hepatitis of enteric transmission worldwide. In South America the overall epidemiology has been little studied, and the burden of the disease remains largely unknown. A research of all scientific articles about HEV circulation in South America until November 2017 was carried out. Human seroprevalences of HEV varied according to the studied population: blood donors presented prevalence rates ranging from 1.8% to 9.8%, while reports from HIV‐infected individuals, transplant recipients and patients on hemodialysis showed higher prevalence rates. Only 2 cases of chronic hepatitis in solid‐organ transplant patients from Argentina and Brazil have been described. Detection of HEV in the swine population is widely prevalent in the region. Anti‐HEV antibodies have also been recently documented in wild boars from Uruguay. Although scarce, studies focused on environmental and food HEV detection have shown viral presence in these kind of samples, highlighting possible transmission sources of HEV in the continent. HEV genotype 3 was the most frequently detected in the region, with HEV genotype 1 detected only in Venezuela and Uruguay. HEV is widely distributed throughout South America, producing sporadic cases of acute hepatitis, but as a possible agent of chronic hepatitis. Finding the virus in humans, animals, environmental samples and food, show that it can be transmitted through many sources, alerting local governments and health systems to improve diagnosis and for the implementation of preventive measures.

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“…In Brazil, the reported seroprevalence rates vary widely and are difficult to interpret. Reported seroprevalence in blood donors varies from 0.44% [11] to 10.0% [12]; rates from 2.0% [13] to 13.0% [14] have been reported in rural populations, and the prevalence ranges from 10.0% [15] to 18.8% [16] in patients with comorbid diagnosis of chronic schistosomiasis. The aim of this study was therefore to systematically evaluate the divergent seroprevalence studies of hepatitis E in adults in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of hepatitis E in adults in Brazil: a systematic review and meta-analysis

Tengan

Figueiredo

Nunes³

et al. 2019

Infect Dis Poverty

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BackgroundHepatitis E virus (HEV) is a member of the Hepeviridae family; it has four main genotypes and one serotype. While genotypes 1 and 2 cause epidemic hepatitis and are transmitted via water and the fecal-oral route, genotypes 3 and 4 are zoonotic. In the various seroprevalence studies of hepatitis E in Brazil, the numbers reported vary widely and are difficult to interpret. The aim of this study was to analyze existing seroprevalence studies of hepatitis E in adults in Brazil.Main textWe searched the PubMed, Latin American and Caribbean Health Sciences and Embase databases for studies published from inception to May 12, 2018 concerning infection by HEV in Brazil without time period or language restrictions. We included studies that presented data concerning hepatitis E seroprevalence in adults in Brazil, had a sample size ≥50 patients and whose method used for the detection of anti-HEV was standardized and commercialized. We also evaluated the quality of the articles using a list of criteria that totalized 9 items. Of the 20 studies ultimately analyzed, 10 (50%) were from the southeast region of Brazil, 3 (15%) were from the central-west region, 3 (15%) were from the northern region, 2 (10%) were from the northeast region and 2 (10%) were from the southern region. Regarding the quality evaluation of the studies, the mean score was 5.6 (range: 4–8). The estimated overall seroprevalence of HEV infection in the adult population was 6.0% (95% CI: 5.0–7.0); in subgroup analyses, we observed that the prevalence of anti-HEV antibodies in blood donors was 7.0% (95% CI: 5.0–8.0), whereas in the general population, it was 3.0% (95% CI: 2.0–4.0).ConclusionsThe results of this systematic review indicate that there should be national investment in the prevention of hepatitis E virus infection in Brazil, including the implementation of improvements in basic sanitation and guidance regarding the appropriate handling of animal waste and the optimal cooking of vegetables, meat and their derivatives.Electronic supplementary materialThe online version of this article (10.1186/s40249-018-0514-4) contains supplementary material, which is available to authorized users.

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Hepatitis E virus seroprevalence among schistosomiasis patients in Northeastern Brazil

Cited by 14 publications

References 27 publications

Human Hepatitis E Virus among Apparently Healthy Individuals in Ogbomoso, South-Western Nigeria

Human Hepatitis E Virus among Apparently Healthy Individuals in Ogbomoso, South-Western Nigeria

Hepatitis E virus in South America: The current scenario

Seroprevalence of hepatitis E in adults in Brazil: a systematic review and meta-analysis

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