Abnormal anal cytology risk in women with known genital squamous intraepithelial lesion

Nobre, Maria do Socorro; Jacyntho, Cláudia; Eleutério, José; Giraldo, Paulo César; Gonçalves, Ana Katherine

doi:10.1016/j.bjid.2016.01.008

Cited by 11 publications

(11 citation statements)

References 17 publications

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“…We did not take into account the time since the organ transplant for each patient, but it was already demonstrated that no significant differences were observed for women with abnormalities in a cervical smear in relation to the time since the transplant procedure. 19 However, this observation is very similar to a study that used the same liquid-based cytology. Using another liquid-based cytology assay, Patel et al 18 found that fewer than 10% of patients displayed anal atypia in renal transplant recipients, which included both men and women.…”

Section: Discussionsupporting

confidence: 81%

“…18 The prevalence of anal cytologic atypia is very high compared with those observed in immunocompetent women using conventional cytology. 19 However, this observation is very similar to a study that used the same liquid-based cytology. 15 Thus, it is possible that the persistence of the viral infection is more important than the presence of atypia.…”

Section: Discussionsupporting

confidence: 81%

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Prevalence of high‐risk HPV and atypia in liquid‐based cytology of cervical and intra‐anal specimens from kidney‐transplanted women

Eleutério

Cavalcante

Gonçalves

et al. 2019

Diagnostic Cytopathology

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Background: There is a high frequency of human papillomavirus (HPV)-induced lesions in cervix and anus of immunosuppressed patients. However, few studies have evaluated these lesions in kidney-transplanted women.Methods: This cross-sectional study examined 31 kidney-transplanted women receiving immunosuppressive therapy at the General Hospital of Fortaleza in Brazil. Cervical and anal samples were collected and preserved in order to perform liquid-based cytology and a real-time polymerase chain reaction assay detecting high-risk HPV. Results: The patients' ages ranged from 31 to 70 years (mean: 42.6 ± 10.4). The age of sexual debut varied from 14 to 30 years (mean: 19.7 ± 3.8). Cervical cytology was diagnosed as atypical in 25.8% of cases (atypical squamous cells of undetermined significance [ASC-US] in 2 [6.2%], atypical squamous cells, but unable to exclude a high-grade squamous intraepithelial lesion in 1 [3.1%], low-grade squamous intraepithelial lesion [LSIL] in 4 [12.4%], and squamous cell carcinoma in 1 [3.1%]). Anal cytology was atypical in 35.4% of cases (ASC-US in 1 [3.2%]and LSIL in 7 [21.7%]). The presence of cervical HPV was confirmed in 22.5% of patients, and anal HPV was found in 48.8% of the cases. The relative risk of atypical anal cytology in cases of atypical cervical cytology was 4.37 (1. 35-14.20). High-risk cervical HPV did not significantly increase the risk of having atypical anal cytology. However, for HPV in the anus, this was associated with a relative risk of 10.18 (1.45-71.54).Conclusion: High-risk HPV and atypical cytology are very common in the cervix and anus of kidney-transplanted women. Furthermore, the presence of HPV in an anal sample correlates with an increased risk of atypical anal cytology. HPV tests could be useful tools for identifying patients who require anal cytology.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 81%

Prevalence of high‐risk HPV and atypia in liquid‐based cytology of cervical and intra‐anal specimens from kidney‐transplanted women

Eleutério

Cavalcante

Gonçalves

et al. 2019

Diagnostic Cytopathology

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“…Studies have shown that women with genital SILs have a higher risk of anal SILs and anal carcinoma. 10 18 19…”

Section: Discussionmentioning

confidence: 99%

Anal High-risk HPV and Liquid-based Cytology of Immunocompetent Brazilian Women with Genital High-risk HPV

Melo

Eleutério

Peixoto

et al. 2022

Rev Bras Ginecol Obstet

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Objective The purpose of this study was to compare the frequency of the occurrence of high-risk human papillomavirus (HPV) and abnormal anal cytology in immunocompetent women with and without HPV-induced genital lesions. Methods This analytical cross-sectional, observational study was conducted between July 2017 and December 2018 in a specialized outpatient clinic of a tertiary hospital in Fortaleza, CE. Fifty-seven immunocompetent women with and without genital intraepithelial lesions were assessed; they were divided into two groups: group 1 was comprised of women with HPV-associated genital lesions (n = 26), and group 2 was comprised of those without HPV-associated genital lesions (n = 31). Samples for liquid-based cytology and high-risk DNA-HPV polymerase chain reaction real-time tests were collected from the cervix and anus. All cases were evaluated using high-resolution anoscopy; biopsies were performed when required. The Fisher exact and chi-squared tests were applied for consolidated data in the contingency table, and the Student t-test and Mann-Whitney U-test for independent variables. Results Anal high-risk HPV infections were more frequent in group 1 (odds ratio [OR], 4.95; 95% confidence interval [CI], 1.34–18.3; p = 0.012), along with concomitant high-risk HPV infections in the uterine cervix and the anus (OR 18.8; 95% CI, 2.20–160; p < 0.001). The incidence of high-risk cervical HPV infection was associated with high-risk anal HPV infection (OR, 4.95; 95% CI, 1.34–18.3; p = 0.012). There was no statistical difference concerning abnormal anal cytology or anoscopy between the groups, and no anal intraepithelial lesion was found in either group. Conclusion Immunocompetent women with HPV-associated genital lesions and high-risk cervical HPV were more likely to have high-risk anal HPV.

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“…Se ha reportado una sensibilidad y una especificidad de la citología anal de 77,3 y 55,5 %, respectivamente, para la detección de NIA (20). Por otra parte, dada la asociación de VPH con la NIA, surge la pregunta sobre si la prueba de detección de VPH-AR podría ser utilizada para la tamización de la NIA de manera similar a como se utiliza para la neoplasia intraepitelial cervical (NIC) (21-23) por lo que un resultado negativo en la prueba de VPH-AR podría evitar procedimientos diagnósticos innecesarios (24). Como paso inicial es importante identificar la prevalencia de la infección del VPH-AR en la región anal en poblaciones de alto riesgo, para determinar la magnitud del problema localmente y, con base en esta prevalencia, evaluar el desempeño operativo de las pruebas de tamización o confirmatorias (25,26).…”

Section: Introducciónunclassified

Prevalencia de infección por virus del papiloma humano de alto riesgo y citología anormal en la zona de transformación anal en mujeres con displasia cervical. Bogotá, Colombia, 2017-2019

Sánchez-Corredor

Guerrero-Machado

Rubio-Romero

et al. 2020

Rev. Colomb. Obstet. Ginecol.

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Objetivo: establecer la prevalencia de infección anal por virus de papiloma humano de alto riesgo (VPH- AR) y citología anal anormal en mujeres con displasia cervical confirmada. Materiales y métodos: estudio de corte transversal que incluyó pacientes entre 30 y 65 años con diagnóstico nuevo de displasia cervical por histopatología, en dos unidades de colposcopia y patología del tracto genital inferior (una de carácter público y otra privada) entre diciembre de 2017 y abril de 2019. Se excluyeron mujeres con infección por virus de inmunodeficiencia humana (VIH), inmuno-compromiso (uso de esteroides, trasplante, quimioterapia), en embarazo o con malformaciones anorrectales. Muestreo consecutivo. Se evaluaron variables sociodemográficas, tipo de relaciones sexuales, el grado de displasia cervical, resultado positivo de prueba de reacción en cadena de la polimerasa para VPH de alto riesgo en canal anal y tipo de VPH-AR identificado (16-18 u otro). Se utilizó estadística descriptiva. Resultados: de 188 candidatas a ingresar se incluyeron 100 pacientes en el análisis, se encontró una prevalencia de 32 % de infección por VPH de alto riesgo y de 2,8% de citología anal anormal (ASCUS) en el canal anal. El 68,8% de las infecciones por VPH-AR en el canal anal correspondió a genotipos de VPH-AR diferentes a 16 o 18. Conclusiones: la prevalencia de infección anal por VPH-AR en mujeres con displasia cervical fue del 32%. Es importante determinar la utilidad del tamizaje del compromiso de la mucosa anal por virus VPH de alto riesgo de cáncer en mujeres con displasia cervical. Se requieren estudios sobre el pronóstico de la infección anal por VPH-AR en las mujeres con displasia cervical.

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Abnormal anal cytology risk in women with known genital squamous intraepithelial lesion

Cited by 11 publications

References 17 publications

Prevalence of high‐risk HPV and atypia in liquid‐based cytology of cervical and intra‐anal specimens from kidney‐transplanted women

Prevalence of high‐risk HPV and atypia in liquid‐based cytology of cervical and intra‐anal specimens from kidney‐transplanted women

Anal High-risk HPV and Liquid-based Cytology of Immunocompetent Brazilian Women with Genital High-risk HPV

Prevalencia de infección por virus del papiloma humano de alto riesgo y citología anormal en la zona de transformación anal en mujeres con displasia cervical. Bogotá, Colombia, 2017-2019

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