Molecular detection of Feline Leukemia Virus in free-ranging jaguars (Panthera onca) in the Pantanal region of Mato Grosso, Brazil

Silva, Carla Patricia Amarante e; Onuma, Selma Samiko Miyazaki; Aguiar, Daniel Moura de; Dutra, Valéria; Nakazato, Luciano

doi:10.1016/j.bjid.2016.01.005

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…FeLV-B horizontal transmission has been described only on 3 previous occasions ( 43 ). One study reported that FeLV-B was detected in a jaguar ( Panthera onca ); however, this analysis was based on a sequence amplified from a 232-bp region of the LTR ( 12 , 21 ). We have clearly documented a full FeLV-B genomic sequence in an endangered non- Felis cat species.…”

Section: Discussionmentioning

confidence: 99%

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Multiple Introductions of Domestic Cat Feline Leukemia Virus in Endangered Florida Panthers1

Chiu¹,

Kraberger²,

Cunningham³

et al. 2019

Emerg. Infect. Dis.

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The endangered Florida panther (Puma concolor coryi) had an outbreak of infection with feline leukemia virus (FeLV) in the early 2000s that resulted in the deaths of 3 animals. A vaccination campaign was instituted during 2003–2007 and no additional cases were recorded until 2010. During 2010–2016, six additional FeLV cases were documented. We characterized FeLV genomes isolated from Florida panthers from both outbreaks and compared them with full-length genomes of FeLVs isolated from contemporary Florida domestic cats. Phylogenetic analyses identified at least 2 circulating FeLV strains in panthers, which represent separate introductions from domestic cats. The original FeLV virus outbreak strain is either still circulating or another domestic cat transmission event has occurred with a closely related variant. We also report a case of a cross-species transmission event of an oncogenic FeLV recombinant (FeLV-B). Evidence of multiple FeLV strains and detection of FeLV-B indicate Florida panthers are at high risk for FeLV infection.

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Section: Discussionmentioning

confidence: 99%

“…FeLV prevalence in domestic cats is variable (prevalence range 3%–18%) ( 13 – 16 ). FeLV has the capacity to infect nondomestic species including jaguars, bobcats, the critically endangered Iberian lynx, and pumas, most notably the endangered puma subspecies, the Florida panther ( Puma concolor coryi ) ( 17 – 21 ). In all non- Felis spp.…”

mentioning

confidence: 99%

Multiple Introductions of Domestic Cat Feline Leukemia Virus in Endangered Florida Panthers1

Chiu¹,

Kraberger²,

Cunningham³

et al. 2019

Emerg. Infect. Dis.

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show abstract

“…It arises by recombination between FeLV-A and enFeLV subsequent to co-packaging of expressed enFeLV and exFeLV transcripts into a single virion, followed by strand displacement during reverse transcription [ 25 , 26 , 27 ]. FeLV-B is tumorigenic [ 24 ], and is considered to be incapable of horizontal transmission unless it is co-transmitted with FeLV-A [ 20 ], with rare exception [ 28 , 29 ]. FeLV-C is a less common subgroup that arises from de novo mutations in env of FeLV-A and has been associated with the development of aplastic anemia [ 3 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Exogenous Feline Leukemia Virusmentioning

confidence: 99%

A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep Sequencing

Chiu

Hoover

VandeWoude

2018

Viruses

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Feline leukemia virus (FeLV) was the first feline retrovirus discovered, and is associated with multiple fatal disease syndromes in cats, including lymphoma. The original research conducted on FeLV employed classical virological techniques. As methods have evolved to allow FeLV genetic characterization, investigators have continued to unravel the molecular pathology associated with this fascinating agent. In this review, we discuss how FeLV classification, transmission, and disease-inducing potential have been defined sequentially by viral interference assays, Sanger sequencing, PCR, and next-generation sequencing. In particular, we highlight the influences of endogenous FeLV and host genetics that represent FeLV research opportunities on the near horizon.

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Immunopathological Disorders in Sheep, Goat, Wild Animals, and Laboratory Animals

Chauhan,

Malik,

Saminathan

et al. 2024

Essentials of Veterinary Immunology and Immunopathology

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Molecular detection of Feline Leukemia Virus in free-ranging jaguars (Panthera onca) in the Pantanal region of Mato Grosso, Brazil

Cited by 6 publications

References 5 publications

Multiple Introductions of Domestic Cat Feline Leukemia Virus in Endangered Florida Panthers1

Multiple Introductions of Domestic Cat Feline Leukemia Virus in Endangered Florida Panthers1

A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep Sequencing

Immunopathological Disorders in Sheep, Goat, Wild Animals, and Laboratory Animals

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