The halo sign of Q fever pneumonia

Zhang, Yi; Zang, Guoqing; Tang, Zisheng; Yu, Yehua

doi:10.1016/j.bjid.2014.11.001

Cited by 4 publications

(9 citation statements)

References 5 publications

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“…Radiological findings are highly polymorphic. Several reports found rounded opacities (446,457,458) with a halo sign suggestive of an angio-invasive process, but classical interstitial or segmental opacities involving the lower lobes are also common (459). CT scanning has shown lobar, segmental, multilobar, or patchy involvement, sometimes associated with lymph node enlargement (446).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Clinical Manifestationsmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…2 Q fever pneumonia can range from mild to severe, and numerous patients have extrapulmonary manifestations, including severe headache, myalgia, and arthralgia. 2,5,6,8,10 The onset of symptoms can be gradual or abrupt, with variable severity. Typically, pneumonia in acute Q fever infection results in a dry to productive cough, pleuritic chest pain, and focal or bilateral infiltrates that are visible on chest radiographs.…”

Section: Discussionmentioning

confidence: 99%

“…6 HRCT is rarely required for the diagnosis of this disease, which may explain the paucity of studies concerning the tomographic findings of acute Q fever. 7,8,17 Nevertheless, in selected cases in which radiographic findings are confusing or coexistent disease is suspected, chest CT may be requested. 17 The HRCT features of acute Q fever pneumonia consist of airspace consolidation or nodules, which may be associated with a halo of ground-glass opacity, in a segmental, patchy, or lobar distribution.…”

Section: Discussionmentioning

confidence: 99%

“…17 The HRCT features of acute Q fever pneumonia consist of airspace consolidation or nodules, which may be associated with a halo of ground-glass opacity, in a segmental, patchy, or lobar distribution. 8,17 Figure 2. Axial HRCT images from a 22-year-old male with Q fever showing peripheral nodules in the left upper lobe (a) and right lower lobe (b, c).…”

Section: Discussionmentioning

confidence: 99%

“…2,4 Pulmonary involvement is possible in the acute and chronic forms. [5][6][7][8] The diagnosis of Q fever is based on serologic, clinical, and radiologic criteria. Polymerase chain reaction (PCR) of whole blood or serum provides rapid results and can be used to diagnose acute Q fever in the first 2 weeks after symptom onset but before antibiotic administration.…”

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confidence: 99%

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