Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children

Pugliese, Camila; Patin, Rose Vega; Palchetti, Cecília Zanin; Claudio, Cristiane Chiantelli; Gouvêa, Aída de Fátima Thomé Barbosa; Succi, Regina Célia de Menezes; Amâncio, Olga Maria Silvério; Cozzolino, Sílvia Maria Franciscato; Oliveira, Fernanda Luísa Ceragioli

doi:10.1016/j.bjid.2014.02.003

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…Imbalance of these trace elements in the body may affect the enzyme activity. This observation was verified by other authors [56]. Such imbalance can contribute to oxidative stress, an imbalance in the generation of free radical and availability of antioxidant protection mechanism, and a situation that can compromise immune system and worsened by HIV-1 infection [57,58].…”

Section: Discussionsupporting

confidence: 59%

Correlation of copper/zinc ratio with superoxide dismutase activity and neutrophil-to-lymphocyte ratio in human immunodeficiency virus type 1 (HIV-1) infected subjects

Emokpae¹

2017

hivar

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Introduction: The important role of nutrition in the pathogenesis of human immunodeficiency virus type-1 (HIV-1) infection has not been sufficiently addressed in sub-Sahara Africa, where the prevalence of HIV infection is high. This study correlates copper-to-zinc ratio with activities of superoxide dismutase and calculated neutrophil-to-lymphocyte ratio in HIV-1-infected subjects. Material and methods: In the study, there were 120 confirmed HIV-1 positive subjects and 100 HIV-1 negative ambulatory healthy controls. Complete blood count, clusters of differentiation (CD4+) lymphocyte count, serum superoxide dismutase (SOD), catalase, copper, and zinc were evaluated using hematology analyzer, FACS flow cytometer, enzyme-linked immunosorbent assay, and atomic absorption spectrophotometer, respectively. Correlation between the measured variables was completed using Pearson correlation coefficient. Results: Serum copper (p < 0.001), catalase (p < 0.05), and neutrophil-to-lymphocyte ratio (NLR) (p < 0.001) were significantly higher, while serum zinc (p < 0.001) was lower in HIV-1 positive than control subjects. Copper/zinc ratio correlated with SOD (r =-0.228; p < 0.02), CD4 + (-0.235; p < 0.02), and NLR (r = 0.198; p < 0.05) in HIV infected subjects. Conclusions: Copper/zinc ratio correlated with NLR, SOD, and CD4 + cell count. Because of the adverse effects associated with imbalance of copper and zinc levels, nutritional status, antioxidant defense mechanism, and inflammatory markers may be assessed periodically in HIV-1-infected patients.

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Section: Discussionsupporting

confidence: 59%

Correlation of copper/zinc ratio with superoxide dismutase activity and neutrophil-to-lymphocyte ratio in human immunodeficiency virus type 1 (HIV-1) infected subjects

Emokpae¹

2017

hivar

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“…Food intake observed in HIV-infected children and adolescents is similar to uninfected patients' , generally inadequate, monotonous, high in sodium, sugar and saturated and trans fats; poor in fruits, milk and milk products, whole grains and fibers in general 11,19 .…”

Section: Food Intakementioning

confidence: 87%

“…Micronutrient deficiencies have been associated with increased mortality in HIV-infected persons and are directly related to the inadequate intake of these nutrients, which implies low serum quantification 33 , impairing the immune system and worsening the patient's prognosis 19 .…”

Section: Food Intakementioning

confidence: 99%

Effects of HAART in the nutritional status of children and adolescents infected by HIV in Brazil: a systematic review

Gratão

Nascimento

2021

Ciênc. saúde coletiva

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The verification of factors associated with growth, body composition and nutritional and nutritional aspects after HIV infection in children or adolescents in Brazil is fundamental for progress in this area. We selected articles published until 2018, available on the platforms PubMed and Lilacs, using the keywords The following descriptors and their associations were used, extracted from MeSH: “Children”, “Adolescent”, “Anthropometry”, “Nutritional Assessment”, “HIV”, “Brazil” adding the filter “and” for advanced searches. A total of 1,450 articles were found, and after selection and full reading, 19 were selected. The studies agreed that children and adolescents living with HIV present or may present alterations in bone metabolism, lipid metabolism and body composition due to infection or associated with therapy. Significant differences were observed in weight and height in infected infants compared to uninfected infants. The evaluation and monitoring of diet quality, as well as serum micronutrient monitoring, are fundamental to guarantee the clinical and treatment conditions of these patients, as well as to prevent disorders due to low nutrient intakes.

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“…La prevalencia de deficiencia sérica de selenio durante la infección por VIH es alta, oscilando entre 53 % -96 %, siendo mayor en pacientes sin TAR (36,37) . En población mexicana, la prevalencia de deficiencia sérica de selenio en pacientes con TAR documentada es 65,9 % (25) .…”

Section: Seleniounclassified

Implicaciones clínicas e inmunológicas de los micronutrientes durante la infección por VIH

Padilla¹,

Moguel

Vargas

et al. 2020

Rev. Nutr. Clin. Metab.

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Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children

Abstract: HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress.

Cited by 10 publications

References 23 publications

Correlation of copper/zinc ratio with superoxide dismutase activity and neutrophil-to-lymphocyte ratio in human immunodeficiency virus type 1 (HIV-1) infected subjects

Correlation of copper/zinc ratio with superoxide dismutase activity and neutrophil-to-lymphocyte ratio in human immunodeficiency virus type 1 (HIV-1) infected subjects

Effects of HAART in the nutritional status of children and adolescents infected by HIV in Brazil: a systematic review

Implicaciones clínicas e inmunológicas de los micronutrientes durante la infección por VIH

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