2014
DOI: 10.1016/j.bjid.2014.01.008
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Pharmacodynamic profiling of commonly prescribed antimicrobial drugs against Escherichia coli isolates from urinary tract

Abstract: Since antimicrobial resistance among uropathogens against current first line agents has affected the management of severe urinary tract infection, we determined the likelihood that antibiotic regimens achieve bactericidal pharmacodynamic exposures using Monte Carlo simulation for five antimicrobials (ciprofloxacin, ceftriaxone, piperacillin/tazobactam, ertapenem, and meropenem) commonly prescribed as initial empirical treatment of inpatients with severe community acquired urinary tract infections. Minimum inhi… Show more

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Cited by 12 publications
(8 citation statements)
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“…The management of UTIs is usually empirical, based on the predictable spectrum of etiologic agents and their susceptibility patterns. Due to the emergence of antimicrobial resistance among uropathogens, the effectiveness of empirical therapy has been affected [ 7 ]. In Chad, antimicrobial susceptibility among pathogens involved in UTIs is poorly investigated.…”
Section: Introductionmentioning
confidence: 99%
“…The management of UTIs is usually empirical, based on the predictable spectrum of etiologic agents and their susceptibility patterns. Due to the emergence of antimicrobial resistance among uropathogens, the effectiveness of empirical therapy has been affected [ 7 ]. In Chad, antimicrobial susceptibility among pathogens involved in UTIs is poorly investigated.…”
Section: Introductionmentioning
confidence: 99%
“…So, the therapeutic regimens using different antibiotic may vary according to country and region, hospital, or community due the access to local epidemiology data (Cuba et al, 2014;Terlizzi et al, 2017).…”
Section: The Problem Of the Resistance Of Uropathogens To Antimicrobi...mentioning
confidence: 99%
“…So, the therapeutic regimens using different antibiotic may vary according to country and region, hospital, or community due the access to local epidemiology data (Cuba et al, 2014;Terlizzi et al, 2017).…”
Section: The Problem Of the Resistance Of Uropathogens To Antimicrobi...mentioning
confidence: 99%