Consensus of the Brazilian Society of Infectious Diseases and Brazilian Society of Clinical Oncology on the management and treatment of Kaposi's sarcoma

Arruda, Érico Antônio Gomes de; Jácome, Alexandre A.; Toscano, Ana Luiza de Castro Conde; Silvestrini, Anderson Arantes; Rêgo, André Santa Bárbara; Wiermann, Evanius Garcia; Cunha, Geraldo Felicio; Melo, Heloísa Ramos Lacerda de; Morejón, Karen Mirna Loro; Goldani, Luciano Zubaran; Pereira, Luiz Carlos; Silva, Mariliza Henrique da; Treistman, Mauro Sergio; Pereira, Mônica Cristina Toledo; Romero, Patricia Maria Bezerra Xavier; Schmerling, Rafael; Guedes, Rodrigo; Camargo, Veridiana Pires de

doi:10.1016/j.bjid.2014.01.002

Cited by 22 publications

(21 citation statements)

References 66 publications

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“…27-29 This can be explained both by the direct action of ART on KSHV as well as by the suspension of the progression of HIV infection and, consequently, the immunodeficiency that predisposes KS. In case series, few patients used ART at the time of KS diagnosis, similar to the data found by Saraceni et al, in which 57% of KS cases were diagnosed before the individual started antiretroviral treatment.…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory characteristics, staging, and outcomes of individuals with AIDS-associated Kaposi's sarcoma at an university hospital

Lima¹,

Araújo

Teixeira

et al. 2017

An. Bras. Dermatol.

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BackgroundKaposi's sarcoma continues to be the most common human immunodeficiency virus - associated neoplasm with considerable morbidity and mortality.ObjectiveTo describe the clinical and laboratory characteristics, initial staging, and outcomes of aids patients with Kaposi's sarcoma at an university hospital of Recife, Pernambuco.MethodsThis is a descriptive study with analytic character, retrospective, of a case series between 2004 and 2014.ResultsOf the 22 patients included in the study, 20 were aged <40 years (72.7%). The majority had CD4+ T lymphocyte counts of <200 cells/mm3 (77.3%) and human immunodeficiency virus loads of <100,000 copies/mL (78.9%). Lesions were most commonly observed on the skin (90%), and internal organs were affected in 11 of the 22 patients. Only 7 (31.8%) of the 22 patients were undergoing antiretroviral therapy (ART) at the time of Kaposis sarcoma diagnosis, and the initial disease staging classification was high risk (Aids Clinical Trials Group Oncology Committee) in 19 of the 22 patients (86.4%). Regarding Kaposi's sarcoma treatment, 17 of 22 patients (77.3%) underwent systemic chemotherapy + ART and 5 were treated exclusively with ART. Eight of the 22 patients died (36.5%); of these, 87.5% had died within one year of Kaposi's sarcoma diagnosis.Limitation of the studyWithout a control group, this study cannot be used to generate hypotheses.ConclusionsDespite the association between aids and late Kaposi's sarcoma diagnosis in the study population, including an unfavorable risk at the time of staging, a lower mortality rate was observed relative to other studies; this might be related to access to a specialized health service.

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Section: Discussionmentioning

confidence: 99%

Clinical and laboratory characteristics, staging, and outcomes of individuals with AIDS-associated Kaposi's sarcoma at an university hospital

Lima¹,

Araújo

Teixeira

et al. 2017

An. Bras. Dermatol.

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“…In Brazil, among people living with HIV/AIDS the mortality rate was substantially decreased, despite this success, approximately 48% out of 734,000 people living with HIV/AIDS are under HAART, and, hence, is still considerable the residual risk of developing KS [Arruda et al, ; Brasil, ]. In people living with HIV/AIDS, previous studies of Brazil reported only an overall seroprevalence of anti‐HHV‐8 ranging from 13.9% to 25.9%.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil

et al. 2016

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This cross-sectional study aimed to estimate the seroprevalence and risk factors for Human herpesvirus 8 (HHV-8) infection among people living with HIV/AIDS in Recife, Pernambuco, Brazil. A total of 500 individuals were tested for antibodies against HHV-8 using the whole-virus ELISA. The prevalence of anti-HHV-8 was 28.6% and the frequency among 140 men who have sex with men (MSM) was 38.6%. In the univariate model, there were significant associations with male gender, detectable HIV load, travel abroad, bissexual, and homossexual orientation. The first HHV-8 seroepidemiologic study, in northeast Brazil, documents a highly prevalent HHV-8 infection among MSM living with HIV/AIDS. J. Med. Virol. 88:2016-2020, 2016. © 2016 Wiley Periodicals, Inc.

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“…Pleural effusion, hypoxemia and acute respiratory failure requiring mechanical ventilation have also been reported in some cases. [13][14][15] Kaposi's sarcoma may involve the tracheobronchial tree, the lung parenchyma and pleura. Pleural involvement occurs only in the presence of parenchymal abnormalities, just as the presence of lesions in the bronchial tree below the tracheal carina is, as a rule, accompanied by parenchymal lesions.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Kaposi’s sarcoma in a female patient: Case report

Petribu¹,

Cisneiros²,

Carvalho³

et al. 2016

Rev. Assoc. Med. Bras.

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SUMMARY Kaposi’s sarcoma (KS) is a multicentric lymphoproliferative malignancy. Most of the time this tumor is confined to the skin and subcutaneous tissue, but it can present with widespread visceral involvement, such as in the lung. Pulmonary KS is the most frequent form in young adult males, in a ratio of 15:1. The disease usually affects individuals with low CD4 lymphocyte counts (<150-200 cells/mm3). We report a case of a female patient aged 35 years, with the presence of skin lesions, self-limiting episodes of diarrhea and weight loss of 15 kg for nearly 9 months, progressing to persistent fever. AIDS was diagnosed and biopsy of the lesions revealed Kaposi’s sarcoma. Computed tomography of the chest showed peribronchovascular thickening, areas of ground glass opacity, condensations with air bronchograms surrounded by ground glass opacity (halo sign) and bilateral pleural effusion. The diagnosis of pulmonary KS is still a challenge, especially due to the occurrence of other opportunistic diseases that may also occur concurrently. Therefore, suspecting this diagnosis based on clinical and laboratory manifestations, and even more with CT findings, is fundamental, especially in patients who already have the cutaneous form of the disease.

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Consensus of the Brazilian Society of Infectious Diseases and Brazilian Society of Clinical Oncology on the management and treatment of Kaposi's sarcoma

Cited by 22 publications

References 66 publications

Clinical and laboratory characteristics, staging, and outcomes of individuals with AIDS-associated Kaposi's sarcoma at an university hospital

Clinical and laboratory characteristics, staging, and outcomes of individuals with AIDS-associated Kaposi's sarcoma at an university hospital

Prevalence of human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil

Pulmonary Kaposi’s sarcoma in a female patient: Case report

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