Low seroprevalence of hepatitis E virus infection in pregnant women in Yunnan, China

Huang, Fen; Ma, Tianwu; Li, Li; Zeng, Weikun; Jing, Shenrong

doi:10.1016/j.bjid.2013.02.006

Cited by 18 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding, though higher than 0% rate reported in a similar cohort in France [45], is lower than rates ranging from 2.6% to 33% recorded by several authors in a similar cohort in different regions of the world [46][47][48][49][50]. Variation in the performance of different ELISA kits employed in these studies may account for the difference in rates reported.…”

Section: Discussioncontrasting

confidence: 79%

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Ijeoma

Faleye

Bakarey

et al. 2017

Preprint

View full text Add to dashboard Cite

Hepatitis E virus (HEV) remains a major public health concern in resource limited regions of the world. Yet data reporting is suboptimal and surveillance system is inadequate. In Nigeria, there is dearth of information on prevalence of acute HEV infection. This study was therefore designed to describe acute HEV infection among antenatal clinic attendees and community dwellers from two geographical regions in Nigeria. Seven hundred and fifty plasma samples were tested for HEV IgM by Enzyme Linked Immunosorbent Assay (ELISA) technique. The tested samples were randomly selected from a pool of 1,115 blood specimens previously collected for viral hepatitis studies among selected populations (pregnant women, 272; Oyo community dwellers, 438; Anambra community dwellers, 405) between September 2012 and August 2013. One (0.4%) pregnant woman in her 3rd trimester had detectable HEV IgM, while community dwellers from the two study locations had zero prevalence rates of HEV IgM. Detection of HEV IgM in a pregnant woman, especially in her 3rd trimester, is of clinical and epidemiological significance. The need therefore exists for establishment of a robust HEV surveillance system in Nigeria and especially amidst the pregnant population in a bid to improve maternal and child health.

show abstract

Section: Discussioncontrasting

confidence: 79%

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Ijeoma

Faleye

Bakarey

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…The most severe clinical manifestation of hepatitis E has been recognized as the high mortality in pregnant women, which has been had extensive attention [5][6][7][8][9][10]. However, the mechanism remains unclear, and the high mortality in pregnancy has been questioned [11][12][13][14][15][16]. These conflicting reports prompted us to investigate whether HEV infection in pregnancy could lead to high maternal mortality and poor outcomes in experimental animals.…”

Section: Discussionmentioning

confidence: 99%

Experimental infection of pregnant rabbits with hepatitis E virus demonstrating high mortality and vertical transmission

Xia

Liu

Zhang

et al. 2015

Journal of Viral Hepatitis

View full text Add to dashboard Cite

A high mortality rate of approximately 20% in pregnant women with hepatitis E has been reported in previous studies. However, other studies showed no difference between pregnant and nonpregnant women in the severity of hepatitis E. To determine the effects of HEV infection on pregnancy, we successfully established HEV infection in six pregnant rabbits (PR) and six nonpregnant rabbits (NPR) with a rabbit HEV isolate, taking three PR and one NPR without HEV infection as controls. Tests for HEV RNA by RT-PCR, anti-HEV antibodies by ELISA and HEV antigen via immunohistochemistry and histopathology were carried out. Two of six infected PR miscarried and three of the remaining four PR died which may be attributed to severe liver necrosis caused by HEV infection. Moreover, vertical transmission was found to be associated with the replication of HEV in placenta, indicated by the presence of HEV RNA and antigen in placenta from the infected PR. Our findings strongly suggest that HEV infection could lead to adverse outcomes in pregnancy and vertical transmission, suggesting the necessity for pregnant women at risk of HEV infection to be vaccinated.

show abstract

“…It is recognized that HEV infections may pose serious threats to pregnant women and fetuses during pregnancy, resulting in congenital defects, spontaneous abortion and even death [Adjei et al, 2009;Goumba et al, 2010;Huang et al, 2013]. Similar to other recently-published evidence [Singh et al, 2003;Purcell and Emerson, 2008;Jacobs et al, 2014], the present study showed that seroprevalence of HEV infection in the third trimester of pregnancy (18.7%) (95% CI 13.7%-23.4%) is higher than that in the second (15.5%) (95% CI 10.7%-20.3%) or the first trimester (15.3%) (95% CI 12.2%-18.4%) of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of hepatitis E virus among pregnant women and control subjects in China

Cong

Sui

Zhang

et al. 2014

Journal of Medical Virology

View full text Add to dashboard Cite

Hepatitis E infection, caused by the hepatitis E virus (HEV), is an important global public health concern, with particularly high mortality in pregnant women. China is generally judged to be an HEV-endemic area, but epidemiological data for HEV among pregnant women are limited. Between June 2011 and July 2013, a case-control study was conducted to estimate the seroprevalence and potential risk factors associated with the acquisition of HEV infection by pregnant women in China. Nine-hundred and ninety pregnant women who visited hospitals for antenatal follow-up or medication in Qingdao and Weihai and 965 control subjects matched by age, gender and residence were examined for the presence of anti-HEV IgG and IgM antibodies by enzyme immunoassays. Socio-demographic and behavioral characteristics from the study subjects were obtained. The overall prevalence of anti-HEV IgG in all 1,955 samples was 20.7%. In pregnant women, 16.2% of samples were anti-HEV IgG positive whereas, in control subjects 25.3% of samples were anti-HEV IgG positive, (P < 0.01). For anti-HEV IgM detection, 62 (3.2%) of the 1,955 serum samples were positive and the seroprevalence in pregnant women and control subjects was 2.6% and 3.6%, respectively. Age, contact with cats, contact with pigs and exposure to soil were found to be associated with HEV infection. These findings demonstrated the high prevalence of HEV and the considerable potential for the transmission of HEV infection in pregnant women in China.

show abstract

Low seroprevalence of hepatitis E virus infection in pregnant women in Yunnan, China

Cited by 18 publications

References 6 publications

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Experimental infection of pregnant rabbits with hepatitis E virus demonstrating high mortality and vertical transmission

Seroprevalence of hepatitis E virus among pregnant women and control subjects in China

Contact Info

Product

Resources

About