Accurate diagnosis and treatment of Vibrio vulnificus infection: a retrospective study of 12 cases

Matsuoka, Yoshinori; Nakayama, Yukishi; Yamada, Tomoko; Nakagawachi, Akira; Matsumoto, Kouichi; Nakamura, Kimihide; Sugiyama, Kyousuke; Tanigawa, Yoshinobu; Kakiuchi, Yoshinobu; Saito, Yoshiro

doi:10.1016/j.bjid.2012.07.017

Cited by 15 publications

(11 citation statements)

References 15 publications

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“…The prognosis of primary septicaemia was found to be worse than that of wound infection ( P < 0.001; Inoue et al, 2008). Recently, Matsuoka et al (2013) investigated and reported 12 patients with V. vulnificus -induced necrotic fasciitis—7 out of 12 died, giving a mortality rate of 58.3% and without exception, all patients involved had underlying diseases (Matsuoka et al, 2013). …”

Section: Occurrence Of Vibrio Vulnificusmentioning

confidence: 99%

Vibrio vulnificus: An Environmental and Clinical Burden

Heng

Letchumanan

Deng³

et al. 2017

Front. Microbiol.

126

114

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Vibrio vulnificus is a Gram negative, rod shaped bacterium that belongs to the family Vibrionaceae. It is a deadly, opportunistic human pathogen which is responsible for the majority of seafood-associated deaths worldwide. V. vulnificus infection can be fatal as it may cause severe wound infections potentially requiring amputation or lead to sepsis in susceptible individuals. Treatment is increasingly challenging as V. vulnificus has begun to develop resistance against certain antibiotics due to their indiscriminate use. This article aims to provide insight into the antibiotic resistance of V. vulnificus in different parts of the world as well as an overall review of its clinical manifestations, treatment, and prevention. Understanding the organism's antibiotic resistance profile is vital in order to select appropriate treatment and initiate appropriate prevention measures to treat and control V. vulnificus infections, which should eventually help lower the mortality rate associated with this pathogen worldwide.

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Section: Occurrence Of Vibrio Vulnificusmentioning

confidence: 99%

Vibrio vulnificus: An Environmental and Clinical Burden

Heng

Letchumanan

Deng³

et al. 2017

Front. Microbiol.

126

114

View full text Add to dashboard Cite

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“…V. cholerae can act as the causative agent of the severe and sometimes lethal disease, cholera, and is probably the most sequenced and clinically important member of Vibrio species (Heidelberg et al, 2000; Egan and Waldor, 2003). V. vulnificus causes septicemia in wound infections; however, despite its high fatality rate, human infections of V. vulnificus are rare (Matsuoka et al, 2013; Tsao et al, 2013). V. parahaemolyticus and V. furnissii infections may lead to gastroenteritis in humans via consumption of raw seafood (Tanabe et al, 2011; Xiang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Vibrio chromosome-specific families

Lukjancenko

Ussery

2014

Front. Microbiol.

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We have compared chromosome-specific genes in a set of 18 finished Vibrio genomes, and, in addition, also calculated the pan- and core-genomes from a data set of more than 250 draft Vibrio genome sequences. These genomes come from 9 known species and 2 unknown species. Within the finished chromosomes, we find a core set of 1269 encoded protein families for chromosome 1, and a core of 252 encoded protein families for chromosome 2. Many of these core proteins are also found in the draft genomes (although which chromosome they are located on is unknown.) Of the chromosome specific core protein families, 1169 and 153 are uniquely found in chromosomes 1 and 2, respectively. Gene ontology (GO) terms for each of the protein families were determined, and the different sets for each chromosome were compared. A total of 363 different “Molecular Function” GO categories were found for chromosome 1 specific protein families, and these include several broad activities: pyridoxine 5' phosphate synthetase, glucosylceramidase, heme transport, DNA ligase, amino acid binding, and ribosomal components; in contrast, chromosome 2 specific protein families have only 66 Molecular Function GO terms and include many membrane-associated activities, such as ion channels, transmembrane transporters, and electron transport chain proteins. Thus, it appears that whilst there are many “housekeeping systems” encoded in chromosome 1, there are far fewer core functions found in chromosome 2. However, the presence of many membrane-associated encoded proteins in chromosome 2 is surprising.

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“…We found that more than 95% of the reported episodes of VNSSTIs occurred in the subtropical western Pacific and Atlantic coastal regions of the northern hemisphere, such as Taiwan, 19 , 21 , 25 , 28 , 31 , 32 , 36 South Korea, 30 , 33 Japan, 18 , 27 , 29 , 34 or the Gulf of Mexico of the United States. 20 , 23 , 26 , 35 The common average weather feature of these areas is a subtropical monsoon climate pattern, which is rarely seen in the southern hemisphere.…”

Section: Discussionmentioning

confidence: 86%

Distribution of Fatal Vibrio Vulnificus Necrotizing Skin and Soft-Tissue Infections

et al. 2016

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Vibrio vulnificus necrotizing skin and soft tissue infections (VNSSTIs), which have increased significantly over the past few decades, are still highly lethal and disabling diseases despite advancing antibiotic and infection control practices. We, therefore, examined the spatiotemporal distribution of worldwide reported episodes and associated mortality rates of VNSSTIs between 1966 and 2014. The PubMed and Cochrane Library databases were systematically searched for observational studies on patients with VNSSTIs. The primary outcome was all-cause mortality. We did random-effects meta-analysis to obtain estimates for primary outcomes; the estimates are presented as means plus a 95% confidence interval (CI). Data from the selected studies were also extracted and pooled for correlation analyses.Nineteen studies of 2227 total patients with VNSSTIs were analyzed. More than 95% of the episodes occurred in the subtropical western Pacific and Atlantic coastal regions of the northern hemisphere. While the number of cases and the number of deaths were not correlated with the study period (rs = 0.476 and 0.310, P = 0.233 and 0.456, respectively), the 5-year mortality rate was significantly negatively correlated with them (rs = −0.905, P = 0.002). Even so, the pooled estimate of total mortality rates from the random-effects meta-analysis was as high as 37.2% (95% CI: 0.265–0.479).These data suggest that VNSSTIs are always an important public health problem and will become more critical and urgent because of global warming. Knowing the current distribution of VNSSTIs will help focus education, policy measures, early clinical diagnosis, and appropriate medical and surgical treatment for them.

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Accurate diagnosis and treatment of Vibrio vulnificus infection: a retrospective study of 12 cases

Abstract: Recognition of the characteristic epidemiology and clinical features of this disease is important, and positive debridement should be performed on suspicion. When the illness reaches an advanced stage, however, amputation should be the immediate treatment of choice.

Cited by 15 publications

References 15 publications

Vibrio vulnificus: An Environmental and Clinical Burden

Vibrio vulnificus: An Environmental and Clinical Burden

Vibrio chromosome-specific families

Distribution of Fatal Vibrio Vulnificus Necrotizing Skin and Soft-Tissue Infections

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