Linezolid-induced angioedema and urticaria in a patient with renal failure

Yang, Meifang; Xu, Min

doi:10.1016/j.bjid.2012.07.007

Cited by 4 publications

(2 citation statements)

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“…Immediate hypersensitivity reactions to linezolid have been reported with symptoms including urticaria, skin flushing, and angioedema [ 64 – 66 ]. In one study, rash and pruritus were reported in 1.7% of the 828 patients who received linezolid as well as two cases of anaphylactoid-type reactions (one with bullous arm lesions and one with throat swelling) [ 64 ].…”

Section: Linezolidmentioning

confidence: 99%

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Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole

Dilley

Geng

2021

Clinic Rev Allerg Immunol

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Hypersensitivity reactions including IgE-mediated and delayed cell-mediated reactions to aminoglycosides, clindamycin, linezolid, and metronidazole are rare. For aminoglycosides, allergic contact dermatitis is the most frequent reaction for which patch testing can be a useful step in evaluation. For clindamycin, delayed maculopapular exanthems are the most common reactions. There are case reports of clindamycin associated with drug rash with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), acute febrile neutrophilic dermatosis, and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). For linezolid, cases of hypersensitivity were exceedingly rare and included urticaria, angioedema, anaphylaxis, delayed rashes, and DRESS. For metronidazole, only rare cases were found across a broad spectrum of reactions including allergic contact dermatitis, fixed drug eruption, angioedema, anaphylaxis, serum sickness-like reaction, SJS/TEN, AGEP, SDRIFE, and a possible case of DRESS. IgE-mediated reactions and anaphylaxis to these types of antibiotics are uncommon, and reports of skin testing concentrations and desensitization protocols are largely limited to case reports and series. Non-irritating skin testing concentrations have been reported for gentamycin, tobramycin, and clindamycin. Published desensitization protocols for intravenous and inhaled tobramycin, oral clindamycin, intravenous linezolid, and oral and intravenous metronidazole have also been reported and are reviewed.

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Section: Linezolidmentioning

confidence: 99%

“…Bishop et al reported that 1 of 44 patients experienced a severe skin rash from linezolid therapy that required drug discontinuation [ 65 ]. Yang and Xu report a case of a patient with angioedema and urticaria 12 h after initiation of linezolid for an Enterococcus faecium infection [ 66 ].…”

Section: Linezolidmentioning

confidence: 99%