Pulmonary cryptococcosis in non-AIDS patients

Jinquan, Yu; Tang, Kejing; Xu, Bowen; Xie, Canmao; Light, Richard W.

doi:10.1016/j.bjid.2012.07.004

Cited by 40 publications

(30 citation statements)

References 17 publications

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“…Most of our patients (87.5%) had pulmonary nodules (solitary: 18.8%, multiple: 68.7%). The high frequency of these lesions is consistent with that reported by other studies [8, 11, 12, 14, 15]. The lesions were located predominantly in the lower lung (62.5%) rather than in the middle (18.8%) or upper lung (37.5%), which was also noted in other studies [11, 16–18], and were found mainly in the right (81.3%) rather than the left (50.0%) lung in most patients.…”

Section: Discussionsupporting

confidence: 93%

“…The clinical descriptions of pulmonary cryptococcosis in HIV-negative individuals are quite limited because of the rarity of the disease itself. In general, males are more frequently infected than females, and, in the present study, the disease also occurred predominantly in males [11, 12]. Nadrous et al reported that about one-third of immunocompetent patients with pulmonary cryptococcosis were asymptomatic [13].…”

Section: Discussionmentioning

confidence: 48%

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Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

et al. 2015

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Objective. The aim of this study was to review HIV-negative patients with pulmonary cryptococcosis to analyze the correlations between clinical characteristics and chest computed tomography (CT) findings. Methods. We retrospectively analyzed medical records of 16 HIV-negative patients with pulmonary cryptococcosis diagnosed at our institution, and clinical characteristics of the patients with nodules or masses without ground-glass attenuation (GGA)/consolidation type were compared with those of patients with inclusive GGA or consolidation type. Results. Host status was immunocompromised (81.2%) in most of the patients, and 6 (37.5%) were asymptomatic. The most frequent radiologic abnormalities on chest CT scans were one or more nodules (87.5%), GGA (37.5%), and consolidations (18.8%). Most lesions were located in the lower lung. Levels of hemoglobin and platelets were significantly lower in patients with inclusive GGA or consolidation type. Although the differences were not significant, patients with inclusive GGA or consolidation type tended to have a C-reactive protein level of ≥1.0 mg/dL. Conclusion. If a patient with anemia and thrombocytopenia shows GGA or consolidation in the lung, pulmonary cryptococcosis should be given careful consideration.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 48%

Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

et al. 2015

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“…Usually, the inhalation of Cryptococcus causes focal pneumonitis, and the infection is generally detected as single or multiple pulmonary nodules (11,12). In immunosuppressed patients, focal infection worsens and can cause life-threatening respiratory failure, fungemia, and meningoencephalitis.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Cryptococcosis with Rapidly Growing Lung Nodules in an End-stage Renal Disease Patient

et al. 2017

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A 73-year-old man with type 2 diabetes mellitus and end-stage renal disease was diagnosed with acute myocardial infarction. He required continuous dialysis after percutaneous coronary intervention. Subsequently, multiple nodules were discovered in both lungs for the first time, and Cryptococcus neoformans was isolated from the patient's sputum, blood, bilateral pleural fluid, and cerebrospinal fluid cultures, resulting in a diagnosis of disseminated cryptococcosis. This case represents an invaluable example of disseminated cryptococcosis with rapidly growing lung nodules in a dialysis patient, and illustrates that dialysis causes innate immune disorder and the reactivation of cryptococcosis.

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“…13 Although latex agglutination can be used as a screening test to detect cryptococcal polysaccharide capsule antigens, this test may yield false positive or negative results. 7,14 Still, Chang et al 3 observed that variations in serum cryptococcal antigen titers were consistent with imaging changes could be used to monitor changes in a patient's condition. Accordingly, extensive development of the latex agglutination test for cryptococcal antigens will significantly influence the detection, diagnosis, monitoring, and treatment of PC.…”

Section: Discussionmentioning

confidence: 99%

A case of pulmonary cryptococcosis with large pericardial effusion diagnosed using cervical lymph node biopsy

Liu

Wei²,

Huang

et al. 2016

Clinical Respiratory J

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Pulmonary cryptococcosis (PC) is a relatively rare infectious disease. It mainly involves the lungs; however, in some patients, the infection could spread to other parts of the body. PC mostly occurs in patients with immune deficiencies. However, PC infections have been reported in non-immunocompromised patients. The diagnosis of PC is challenging in patients without immune deficiencies. Here, the case of a 27-year-old immunocompetent woman who was diagnosed with PC was report. She had unexplained fever and a history of close contact with poultry feathers. Lesions were observed in the lungs, pleural cavity, pericardium, and cervical lymph nodes. Biopsy of the cervical lymph nodes helped in the pathological diagnosis of PC. She was treated with fluconazole, and the lesions disappeared. They present this case to encourage detailed inquiry of medical history in such patients, improve the diagnostic awareness of clinicians, and help reduce the likelihood of misdiagnosis.

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Pulmonary cryptococcosis in non-AIDS patients

Abstract: Non-AIDS patients with pulmonary cryptococcosis have a good prognosis with appropriate management.

Cited by 40 publications

References 17 publications

Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

Disseminated Cryptococcosis with Rapidly Growing Lung Nodules in an End-stage Renal Disease Patient

A case of pulmonary cryptococcosis with large pericardial effusion diagnosed using cervical lymph node biopsy

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