2012
DOI: 10.1016/j.bjid.2012.06.012
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Abstract: Hematopoietic progenitor cells from peripheral blood (HPCPB) are commonly used for autologous and allogenic transplants in patients with most various onco-hematological diseases, and despite the utilization of sterile techniques during collection and processing of these products, bacterial contamination can occur. This study aimed to investigate the microbial contamination of HPCPB products. Microbial cultures of 837 HPCPB products between the year 2000 and 2009 were retrospectively analyzed to determine the i… Show more

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Cited by 27 publications
(10 citation statements)
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“…15 Most hospital strains are resistant to a wide range of antibiotics, including macrolide and vancomycin, 15-17 and also have been recognized as β-lactamases producers, causing resistance to penicillins and cephalosporins. 18 Few studies have focused on E faecalis isolated from surgical wound infections and bacteremia. In this regard, little is known about the prevalence of E faecalis isolated from surgical wound infections and bacteremia, their antimicrobial susceptibility, and the mechanisms of antibiotic resistance particularly in developing countries, which are investigated in the current study…”
Section: Introductionmentioning
confidence: 99%
“…15 Most hospital strains are resistant to a wide range of antibiotics, including macrolide and vancomycin, 15-17 and also have been recognized as β-lactamases producers, causing resistance to penicillins and cephalosporins. 18 Few studies have focused on E faecalis isolated from surgical wound infections and bacteremia. In this regard, little is known about the prevalence of E faecalis isolated from surgical wound infections and bacteremia, their antimicrobial susceptibility, and the mechanisms of antibiotic resistance particularly in developing countries, which are investigated in the current study…”
Section: Introductionmentioning
confidence: 99%
“…As the low amount of NCSCs within their respective niches of the adult human body limits their direct use for transplantations, in vitro expansion remains as a vital alternative. Such necessary cultivation procedures greatly increase the risk of transmitting infectious agents [2], such as viruses [30,31] or bacteria [3] together with the transplant. In this regard, the FDA, as well as respective bodies of the European Union (Euro GMP guidelines), prescribe good tissue handling practices in a sterile environment with minimal contamination risk as well as recommend against the use of animal-derived sera [5,12,32].…”
Section: Discussionmentioning
confidence: 99%
“…However, the relative abundances of available endogenous stem cells in their respective niches within the human body are too low to achieve significant therapeutic effects if transplanted directly into the patient without prior in vitro expansion [1]. Although there is a clear need for expansion steps prior to transplantation, cultivation of stem cells in vitro presents the inherent challenges of increasing risk of contamination, for example by transmitting infectious agents [2] or bacteria [3]. …”
Section: Introductionmentioning
confidence: 99%
“…Therefore, a few bacteria could cause a life‐threatening infection. As reported by Dullis et al ., 36 of 837 stem cell preparations were contaminated by coagulase‐negative Staphylococcus (4·3%) . This result demonstrates a residual transfusion‐transmitted risk of approximately one log higher than the risk for platelets.…”
Section: Introductionmentioning
confidence: 99%