Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges

Santos, Tayse Silva dos; Tavares, Renato; Farias, Danielle Leão Cordeiro de

doi:10.1016/j.bjhh.2016.09.014

Cited by 33 publications

(35 citation statements)

References 55 publications

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“…Splenic marginal zone lymphoma (SMZL) is a non-Hodgkin lymphoma malignancy of mature B-cells that originally involves the spleen, but it can also affect peripheral organs. SMZL is a rare malignancy that accounts for less than 2% of all lymphomas and accounts for less than 1% of non-Hodgkin's lymphomas [26]. Di Lisio et al evaluated a set of miRNAs in B cell lymphomas, including SMZL identifying expressed miRNAs in varying types of B-cell lymphomas.…”

Section: Mir-144 In Splenic Marginal Zone Lymphomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.Int. J. Mol. Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers. More than 50% of miRNA genes were discovered to be located within the genomic regions that are involved in cancers, suggesting their role in human cancer pathogenesis. In pathological conditions, MiRNAs can negatively regulate gene expression and they are associated with tumor growth, apoptosis, invasion, and metastasis. In the past, several studies have indicated the ability of miRNAs in the inhibition of tumors as a critical option for the improvement of cancer therapy [4,5]. Tumor activator miRNAs, called oncomiRs, are overexpressed in various cancers. On the contrary, suppressive tumor miRNAs are underexpressed [6][7][8]. Among several miRNAs assessed, miR-144s seem to have a role in several cancers. These miRNAs are located in the chromosomal region 17q11.2, being significantly destroyed in many types of cancers. The predicted stem-loop structure of miR-144s recognized by the miRBase (http://mirbase.org/) is shown in Figure 1A. The miR-144 hairpin gives rise to the "guide strand" miR-144-5p and the sister "passenger" strand miR-144-3p ( Figure 1B).

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Section: Mir-144 In Splenic Marginal Zone Lymphomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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“…There are no defining diagnostic molecular features of SMZL, but characteristic findings in a minority of cases include del(7q), trisomy 3, NOTCH2 mutations, and KLF2 mutations (39,40). There are no defining diagnostic molecular features of SMZL, but characteristic findings in a minority of cases include del(7q), trisomy 3, NOTCH2 mutations, and KLF2 mutations (39,40).…”

Section: Cd5-negative Cd10-negative Small B-cell Neoplasmsmentioning

confidence: 99%

“…SMZL lacks most HCL markers, but may weakly express CD103. There are no defining diagnostic molecular features of SMZL, but characteristic findings in a minority of cases include del(7q), trisomy 3, NOTCH2 mutations, and KLF2 mutations (39,40). Recently, expression of CD1d in conjunction with CD200 was reported to be of diagnostic utility in sub-classification of CD5-negative/CD10-negative B-cell neoplasms (41,42).…”

Section: Cd5-negative Cd10-negative Small B-cell Neoplasmsmentioning

confidence: 99%

The current role of clinical flow cytometry in the evaluation of mature B‐cell neoplasms

Seegmiller

Hsi

Craig

2018

Cytometry Part B Clinical

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Flow cytometry (FC) has a well-established role in the diagnostic evaluation of mature B-cell neoplasms. Effective assessment for lineage associated antigens, aberrant antigen expression, and immunoglobulin light chain restriction requires a welldesigned, optimized, and controlled FC assay. However, it is important for hematopathologists to know when flow cytometry has a more limited role, and other modalities, such as immunohistochemistry, cytogenetic and molecular testing, are more important. This review will discuss the features of an optimal FC assay for the evaluation of mature B-cell neoplasms, and the current role of FC in the diagnosis and sub-classification, prognostic assessment, identification of therapeutic targets, and assessment for disease response to therapy.

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“…Both were positive for the B-cell markers (Figure 6M-N'). These features are reminiscent of human SMZL (Splenic Marginal Zone B-cell -Lymphoma), a clonal B-cell neoplasm that manifests itself in elderly patients and consists of small lymphocytes that infiltrate the lymph nodes and other organs(Arcaini et al, 2016;Piris et al, 2017;Santos et al, 2017). As would be expected, the enlarged lymph nodes and spleens were highly proliferative as indicated by Ki67 and phospho-H3 staining (Supplemental…”

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confidence: 66%

“…For example, Notch1 promotes T-cell development (Pui et al, 1999;Radtke et al, 2010;Radtke et al, 1999), while Notch2 is indispensable for Marginal Zone B-cell (MZB) development (Gibb et al, 2010;Hozumi et al, 2004;Liu et al, 2015;Maillard et al, 2004;Moran et al, 2007;Saito et al, 2003;Tanigaki et al, 2002;Witt et al, 2003). Accordingly, elevated Notch1 signaling is oncogenic in T-cells driving Acute Lymphoblastic Leukemia (T-ALL) (Ellisen et al, 1991;Weng et al, 2004) while increased Notch2 signaling is associated with splenic marginal zone B-cell transformation (Arcaini et al, 2016;Piris et al, 2017;Santos et al, 2017). Inversely, where Notch signals promote differentiation, the pathway can have a tumor suppressor function with diminished Notch signaling being associated with cancer (Demehri et al, 2009;Koch and Radtke, 2007).…”

Section: Introductionmentioning

confidence: 99%

Exposure to Mites Sensitizes Intestinal Stem Cell Maintenance, Splenic Marginal Zone B Cell Homeostasis, And Heart Development to Notch Dosage and Cooperativity

Kobia

Preusse

Dai

et al. 2020

Preprint

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Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo-or heterodimerize, essential for cooperative binding to sequence paired sites (SPS) located near many Notch-regulated genes. While most known Notch-dependent phenotypes were unaffected in Notch1/2 dimer-deficient mice, a subset of tissues proved highly sensitive to loss of cooperativity. These phenotypes include heart development, compromising viability in combination with low gene dose, and the gut, developing ulcerative colitis in response to 1% DSS. The most striking phenotypes -gender imbalance and splenic marginal zone B cell lymphoma -emerged in combination with dose reduction or when challenged by chronic fur mite infestation. This study highlights the role of the environment in malignancy and colitis, and is consistent with Notch-dependent anti-parasite immune responses being compromised in the dimer deficient animals. Highlights• Notch dimerization has an in vivo role in contributing to intestinal homeostasis • Loss of cooperativity can manifest as Notch gain or loss of function phenotypes • Mite infestation exacerbates all phenotypes, triggers MZB hyperproliferation in mutant animals • Mite-infested mutant mice develop SMZL with age 3

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Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges

Cited by 33 publications

References 55 publications

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

The current role of clinical flow cytometry in the evaluation of mature B‐cell neoplasms

Exposure to Mites Sensitizes Intestinal Stem Cell Maintenance, Splenic Marginal Zone B Cell Homeostasis, And Heart Development to Notch Dosage and Cooperativity

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