Detection of Human Adenovirus (species-C, -D and -F) in an allogeneic stem cell transplantation recipient: a case report

Santos, Hugo César Pereira; Borges, F.; Arantes, Adriano de Moraes; Souza, Menira

doi:10.1016/j.bjhh.2016.09.006

Cited by 6 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An investigation in HIV-seropositive and -seronegative children with diarrhea in Brazil reported a significantly higher rate of co-infections with >1 enteric virus including NoV, AdV and human bocavirus in HIV-1 seropositive children [110]. There have also been a number of case reports of severe co-infections in immunocompromised individuals, such as those of AdV and coxsackievirus detected in a child with a primary immunodeficiency with persistent severe diarrhea [111], or AdV and NoV co-infection reported in a patient diagnosed with chronic myeloid leukemia undergoing stem cell transplantation [112]. Certainly, immunocompromised patients with AGE are at increased risk of complications and prolonged hospitalizations.…”

Section: Co-infection In Acute Gastroenteritis (Age)mentioning

confidence: 99%

Enteric Viral Co-Infections: Pathogenesis and Perspective

Makimaa

Ingle

Baldridge

2020

Viruses

View full text Add to dashboard Cite

Enteric viral co-infections, infections involving more than one virus, have been reported for a diverse group of etiological agents, including rotavirus, norovirus, astrovirus, adenovirus, and enteroviruses. These pathogens are causative agents for acute gastroenteritis and diarrheal disease in immunocompetent and immunocompromised individuals of all ages globally. Despite virus–virus co-infection events in the intestine being increasingly detected, little is known about their impact on disease outcomes or human health. Here, we review what is currently known about the clinical prevalence of virus–virus co-infections and how co-infections may influence vaccine responses. While experimental investigations into enteric virus co-infections have been limited, we highlight in vivo and in vitro models with exciting potential to investigate viral co-infections. Many features of virus–virus co-infection mechanisms in the intestine remain unclear, and further research will be critical.

show abstract

Section: Co-infection In Acute Gastroenteritis (Age)mentioning

confidence: 99%

Enteric Viral Co-Infections: Pathogenesis and Perspective

Makimaa

Ingle

Baldridge

2020

Viruses

View full text Add to dashboard Cite

show abstract

“…HAdV species F (including HAdV types 40 and 41) are commonly observed as causes of acute gastroenteritis in the general population and are rarely associated with disseminated infection or disease. Few cases of systemic infections have been described in adult and pediatric HSCT patients 5–7 but HAdV‐F41 had not been linked to acute hepatitis or liver cytolysis. Recent phylogenetic analyses of 65 HAdV‐F41 complete genome indicated three lineage co‐circulating for many years and not identified new highly pathogenic strains that could explain resurgence and hepatitis cases in children 8 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adenovirus F41 infection and liver cytolysis in adult hematopoietic stem cell transplant recipients

Lefeuvre,

Thepot,

Mercier‐Delarue

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

Human adenoviruses (HAdVs) of the F species are commonly responsible for acute gastroenteritis. A few cases of systemic infections have been described in adults or children who have received a hematopoietic stem cell transplant (HSCT), but with no report of liver cytolysis. Since January 2022, several countries have reported an increase in cases of acute hepatitis of unknown cause in children. Adenovirus species F type 41 (HAdV‐F41) infection was predominantly identified. The objective of this study is to describe HAdV‐F41 infections diagnosed since January 2022 in adult HSCT recipients in two French hospitals. All four patients had diarrhea and liver cytolysis at the time of diagnosis of infection. HAdV viremia was observed in three patients (#1, #3, and #4), but no disseminated disease was reported. HAdV whole genome sequencing and metagenomics characterization were performed on stool and blood samples. The complete HAdV‐F41 genome sequence was obtained for three patients and phylogenetic analysis showed that the strains consisted of similar lineage (2b). We did not identify any new HAdV‐F41 strains. Metagenomics analysis found adeno‐associated virus 2 and torque‐teno virus infection in patient #1 and Epstein–Barr virus in patient #4. This is the first case series reporting liver cytolysis during HAdV‐F41 infection in adult HSCT patients.

show abstract

“…They can cause a range of infections from asymptomatic to localized or disseminated [3], including acute respiratory disease [7, 8], keratoconjunctivitis [8], pharyngeal–conjunctival fever [1] and hemorrhagic cystitis [7, 9]. Less frequent complications are arthritis, encephalitis [10, 11], gastroenteritis [12, 13] and hepatitis [7, 14]. …”

Section: Introductionmentioning

confidence: 99%

Co-infection with human polyomavirus BK enhances gene expression and replication of human adenovirus

Bil‐Lula

Woźniak

2018

Arch Virol

View full text Add to dashboard Cite

Immunocompromised patients are susceptible to multiple viral infections. Relevant interactions between co-infecting viruses might result from viral regulatory genes which trans-activate or repress the expression of host cell genes as well as the genes of any co-infecting virus. The aim of the current study was to show that the replication of human adenovirus 5 is enhanced by co-infection with BK polyomavirus and is associated with increased expression of proteins including early region 4 open reading frame 1 and both the large tumor antigen and small tumor antigen. Clinical samples of whole blood and urine from 156 hematopoietic stem cell transplant recipients were tested. We also inoculated adenocarcinomic human alveolar basal epithelial cells with both human adenovirus 5 and BK polyomavirus to evaluate if co-infection of viruses affected their replication. Data showed that adenovirus load was significantly higher in the plasma (mean 7.5 x 103 ± 8.5 x 102 copies/ml) and urine (mean 1.9 x 103 ± 8.0 x 102 copies/ml) of samples from patients with co-infections, in comparison to samples from patients with isolated adenovirus infection. In vitro co-infection led to an increased (8.6 times) expression of the adenovirus early region 4 open reading frame gene 48 hours post-inoculation. The expression of the early region 4 open reading frame gene positively correlated with the expression of BK polyomavirus large tumor antigen (r = 0.90, p < 0.0001) and small tumor antigen (r = 0.83, p < 0.001) genes. The enhanced expression of the early region 4 open reading frame gene due to co-infection with BK polyomavirus was associated with enhanced adenovirus, but not BK polyomavirus, replication. The current study provides evidence that co-infection of adenovirus and BK polyomavirus contributes to enhanced adenovirus replication. Data obtained from this study may have significant importance in the clinical setting.

show abstract

Detection of Human Adenovirus (species-C, -D and -F) in an allogeneic stem cell transplantation recipient: a case report

Cited by 6 publications

References 9 publications

Enteric Viral Co-Infections: Pathogenesis and Perspective

Enteric Viral Co-Infections: Pathogenesis and Perspective

Adenovirus F41 infection and liver cytolysis in adult hematopoietic stem cell transplant recipients

Co-infection with human polyomavirus BK enhances gene expression and replication of human adenovirus

Contact Info

Product

Resources

About