2015
DOI: 10.1016/j.bjhh.2014.11.009
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Abstract: ObjectiveTo assess the impact of the implementation of neonatal screening on hospitalization and death rates due to sickle cell disease in patients from the state of Maranhão, Brazil.MethodsA descriptive study was performed of all inpatients and deaths of patients with a diagnosis of sickle cell disease in Maranhão between 1999 and 2012. Data were collected from the Hospital Information System of the Brazilian National Health Service (SUS) and the Death Information System of the Ministry of Health. The impleme… Show more

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Cited by 14 publications
(12 citation statements)
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References 10 publications
(15 reference statements)
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“…Eight studies on mortality by SCD were carried out in the Brazilian states of Maranhão, 19 Bahia, 20 Minas Gerais, 21 , 22 , 23 Rio de Janeiro 24 , 25 and Mato Grosso do Sul. 26 …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Eight studies on mortality by SCD were carried out in the Brazilian states of Maranhão, 19 Bahia, 20 Minas Gerais, 21 , 22 , 23 Rio de Janeiro 24 , 25 and Mato Grosso do Sul. 26 …”
Section: Resultsmentioning
confidence: 99%
“…Possible explanations for an increase both in hospitalization and mortality rates after implementing neonatal screening are under-reporting of the disease due to difficulty of diagnosis, insufficient hospital care, incorrect use of the international disease classification (ICD) code and lack of hospital registry 19 . The authors from Bahia concluded that there is a lack of studies correlating mortality in this genetic disorder and they highlighted the need for filling out death certificates correctly 20 …”
Section: Discussionmentioning
confidence: 99%
“…The socioeconomic status of the population also hinders access to all available treatments through SUS. 27 The introduction and scope of the neonatal screening program (NSP) in the whole country after 2014 has not resulted yet in improved survival for patients with sickle-cell diseases in Brazil. 28 Nonetheless, the introduction of allogeneic BMT as a therapeutic option in SUS for patients with sickle-cell diseases was a step forward in the fight against this not so benign disease.…”
Section: Sources Of Alternative Hematopoietic Stem Cellsmentioning
confidence: 99%
“…In this issue of the Revista Brasileira de Hematologia e Hemoterapia (RBHH), Lima et al 12 analyze trends in mortality and hospital admission rates for patients (not only children) with SCD in a 14-year period, comparing the data before and after the introduction of a newborn screening program in Maranhão, a northeastern state in Brazil. The total number of recorded hospital admissions increased from 128 in the first seven-year period (‘pre-newborn screening’ – 1999–2005) to 840 in the ‘post-newborn screening’ period (2006–2012).…”
mentioning
confidence: 99%
“…In this comparison, the lower hospitalization rate for Maranhão and Bahia relative to Rio de Janeiro and São Paulo is due not only to under-reporting of patients (the ‘invisible’ disease), but also, probably, to lower level of health care for patients with SCD in these poorer states demonstrating “the social differences that exist between regions in Brazil”. 12 …”
mentioning
confidence: 99%