Utility of the p53 mutant protein in patients with low-risk myelodysplastic syndrome

Yao, David; Lima, Marcos de

doi:10.1016/j.bjhh.2014.03.014

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…These mutations are essential in not only determining the prognosis but also constituting a platform for the current and future novel and targeted therapies for various types of myelodysplasia (Tables 4 and 6) [34][35][36][37][38][39]. mutations often present with severe thrombocytopenia, complex cytogenetic abnormalities, an increased risk of leukemic transformation, and a shorter survival [41,42]. Patients with mutant p53, compared to patients carrying wild-type p53, have the following features: older age, anemia, and leucopenia at the time of diagnosis and shorter median survival.…”

Section: Genetic Mutations Described In Mdss and 5q-syndromementioning

confidence: 99%

“…Patients with mutant p53, compared to patients carrying wild-type p53, have the following features: older age, anemia, and leucopenia at the time of diagnosis and shorter median survival. Molecular identification of mutant p53 contributes to the risk stratification of patients with lower-risk MDS that may alter the treatment approach [41]. TP53 mutations develop at an early disease stage in almost 20% of patients with lower-risk MDS having del (5q) [42].…”

Section: Genetic Mutations Described In Mdss and 5q-syndromementioning

confidence: 99%

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Myelodysplastic Disorders, 5q-Syndrome

Al-Anazi¹

2016

Myelodysplastic Syndromes

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The myelodysplastic syndromes (MDSs) are characterized by ineffective erythropoiesis and progressive cytopenia and ultimately affected patients develop acute myeloid leukemia (AML) or die from advanced bone marrow (BM) failure. Myelodysplastic syndrome (MDS) with isolated del (5q) is a common type of MDS with specific pathological and clinical manifestations including refractory anemia. It is usually treated by (1) supportive measures including blood transfusions that may cause iron overload that requires iron chelation therapy, (2) targeted therapies such as the immunomodulatory drug lenalidomide, and (3) hematopoietic stem cell transplantation (HSCT) in transplant eligible individuals. The establishment of the various prognostic systems, the discovery of the new genetic mutations, and the identification of new targets, in MDSs in general and in 5q-syndrome in particular, will hopefully translate into more pinpointed targeted therapies that will further improve the outcomes of patients having these disorders.

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Section: Genetic Mutations Described In Mdss and 5q-syndromementioning

confidence: 99%

Section: Genetic Mutations Described In Mdss and 5q-syndromementioning

confidence: 99%

Myelodysplastic Disorders, 5q-Syndrome

Al-Anazi¹

2016

Myelodysplastic Syndromes

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Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma

Xavier

Guimarães

Fraga

et al. 2021

PPL

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Background:: Oral cancer is a significant health problem worldwide. Oral squamous cell carcinoma (OSCC) is a malignant neoplasm of epithelial cells that mostly affects different anatomical sites in the head and neck and derives from the squamous epithelium or displays similar morphological characteristics. Generally, OSCC is often the end stage of several changes in the stratified squamous epithelium, which begin as epithelial dysplasia and progress by breaking the basement membrane and invading adjacent tissues. Several plant-based drugs with potent anti-cancer effects are considered inexpensive treatments with limited side effects for cancer and other diseases. Objective:: The aim of this review is to explore whether some Brazilian plant extracts or constituents exhibit anti-tumorigenic activity or have a cytotoxic effect on human oral carcinoma cells. Methods:: Briefly, OSCC and several metabolites derived from Brazilian plants (i.e., flavonoids, vinblastine, irinotecan, etoposide and paclitaxel) were used as keywords to search the literature on PubMed, GenBank and GeneCards. Results:: The results showed that these five chemical compounds found in Cerrado Biome plants exhibit anti-neoplastic effects. Evaluating the compounds revealed that they play a main role in the regulation of cell proliferation. Conclusion:: Preserving and utilising the biodiversity of our planet, especially in unique ecosystems, such as the Cerrado Biome, may prove essential to preserving and promoting human health in modern contexts.

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Utility of the p53 mutant protein in patients with low-risk myelodysplastic syndrome

Cited by 2 publications

References 14 publications

Myelodysplastic Disorders, 5q-Syndrome

Myelodysplastic Disorders, 5q-Syndrome

Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma

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