Homocysteine and vitamin B12 status and iron deficiency anemia in female university students from Gaza Strip, Palestine

Sirdah, Mahmoud M.; Yassin, Maged M.; Shekhi, Sabreen El; Lubbad, Abdel Monem

doi:10.1016/j.bjhh.2014.03.005

Cited by 17 publications

(12 citation statements)

References 25 publications

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“…which is in agreement agreement with our results, Sirdah et al (27) studied the homocysteine and vitamin B 12 status in females with iron deficiency anemia. They found that there were significant negative correlations between homocysteine level and vitamin B12 and hemoglobin levels (r=-0.361 and r=-0.364 respectively; P<0.0001) (27) .Also, in the study of Yassin et al (28) , to assess the association between homocysteine and different hematological indices in hemodialysis patients, they found that homocysteine correlated inversely with hemoglobin (r=-0.733, P=0.0001) and APTT(r=-0.690, P=0.0001) (28) .Moreover, Narang et al (29) studied vitamin B12 level in patients with metabolic syndrome and they found that there was a positive correlation (r=0.346, P=0.002) between vitamin B12 and hemoglobin level (29) .…”

Section: Discussionsupporting

confidence: 94%

The Relation between Serum Homocystiene Level and Recurrent Abortion in Egyptian Women

Ellatef

Beteha

Hasan

et al. 2018

Egyptian Journal of Hospital Medicine

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Background: Early pregnancy loss is defined as the termination of pregnancy before 20 weeks' gestation or with a fetal weight of <500 g. Of those that are recognized, 15-20% result in spontaneous abortions (SABs) or ectopic pregnancies. Approximately 5% of couples trying to conceive have two consecutive miscarriages, and approximately 1% of couples have three or more consecutive early pregnancy loss. Increased levels of homocysteine may be due to inadequate dietary intake of folate and vitamin B12 and inherited defects within the methionine-hmocysteine pathway such as MTHFR c677T gene polymorphism. Hyperhomocysteinemia is associated with the syndromes of repeated miscarriage. Objective: The aim of the current study is to estimate the serum levels of Homocystine and vitamin B12 and their relation to prevalence of recurrent spontaneous abortion in pregnancies with history of recurrent miscarriage. Subjects and Methods: In this study 80 pregnant women classified into two groups: GroupI:60 consecutive pregnant women who had suffered from two or more miscarriages, and Group II: 20 pregnant women with no history of abortion .The following estimations were done (for each woman in the study): serum homocysteine and vitaminB12 were estimated using ELISA technique. Results: Results showed a significant increase in serum level of homocysteine in the first group compared to control group(p<0.0001) and a low serum level of vitamin B12 which was significantly decreased in the study group (group 1) compared to control group(p<0.0001). Moreover, Our results showed a negative correlation between homocysteine and vitamin B12. Conclusion: The elevated serum homocysteine levels during pregnancy were significantly associated with recurrent pregnancy losses. Moreover, reduced serum vitamin B12 level was considered a risk for recurrent miscarriage. Homocysteine is most sensitive and specific parameters in the recurrent pregnancy losses.

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Section: Discussionsupporting

confidence: 94%

The Relation between Serum Homocystiene Level and Recurrent Abortion in Egyptian Women

Ellatef

Beteha

Hasan

et al. 2018

Egyptian Journal of Hospital Medicine

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“…[ 56,57] Zinc Zinc acts as a catalyst in haem metabolism. Zinc and iron deficiency were reported to be strongly correlated.…”

Section: Micronutrients/food Components Notes Referencesmentioning

confidence: 99%

Pulse Probiotic Superfood as Iron Status Improvement Agent in Active Women—A Review

2021

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Active women or women of reproductive age (15–49 years old) have a high risk of suffering from anaemia. Anaemia is not solely caused by iron deficiency, however, the approaches to improve iron status in both cases are greatly related. Improving the iron status of active women can be done by dietary intervention with functional food. This review aims to provide insights about the functional food role to increase iron absorption in active women and the potency of pulse probiotic superfood development in dry matrices. Results showed that the beneficial effect of iron status is significantly improved by the synergic work between probiotic and prebiotic. Furthermore, chickpeas and lentils are good sources of prebiotic and the consumption of pulses are related with 21st century people’s intention to eat healthy food. There are wide possibilities to develop functional food products incorporated with probiotics to improve iron status in active woman.

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“…25,26 The present study found adverse pregnancy outcomes like IUD, still birth with increased levels of serum homocysteine levels. 27,28…”

Section: Studies Done By Ferdausi Et Al Sanlikan Et Al and Kananmentioning

confidence: 99%

Correlation of serum homocysteine levels in pregnancy related hypertensive disorders versus normotensive pregnancies

Hymavathi

Shukla

Madhuri

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Homocysteine concentrations decrease during normal pregnancy, but this does not occur in pre-eclampsia. In pre-eclampsia, homocysteine levels further increase with severity of pre-eclampsia. Elevated homocysteine levels can be due to genetic or multifactorial deficit or a combination of both.Methods: The present study is conducted at department of obstetrics and gynaecology, Narayana Medical College and Hospital, Nellore. 200 pregnant (100 women with pregnancy related hypertensive disorders and 100 normotensive pregnants) recruited. Maternal serum Homocysteine levels were analyzed among women with pregnancy related hypertensive disorders and compared with normotensive pregnant. Chemiluminescence immunoassay was used for determining the Homocysteine levels.Results: The study revealed significant elevation in the levels of homocysteine in pre-eclamptic women (17.54±5.34) compared to normotensive women (7.59±1.91). The study showed a strong association between serum homocysteine levels and severity of pre-eclampsia. The mean homocysteine levels in women with severe Pre-eclampsia (20.59±4.3) were significantly higher than those with mild pre-eclampsia (15.17±1.9). A positive correlation is found between homocysteine levels with serum uric acid and LDH demonstrating the harmful action of hyperhomocysteinemia upon the endothelium. A negative correlation is found between homocysteine levels with hemoglobin and hematocrit even though in anemic patients the hematological levels are found to be little high due to hemoconcentration. The perinatal outcome in women with raised levels of homocysteine was poor with an increased incidence of IUGR (41%), SGA (9%), still births (3%) and IUD (4%) among women with pregnancy related hypertensive disorders when compared to normotensive pregnant women.Conclusions: Elevated levels of homocysteine can be reduced by administering vitamins which help by increasing the metabolism of homocysteine. The internationally accepted treatment for hyperhomocystenemia is using a combination of folic acid 400 µg, vitamin B12 500 µg and pyridoxine 10mg initiating from pre-conceptional period can be used.

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Homocysteine and vitamin B12 status and iron deficiency anemia in female university students from Gaza Strip, Palestine

Cited by 17 publications

References 25 publications

The Relation between Serum Homocystiene Level and Recurrent Abortion in Egyptian Women

The Relation between Serum Homocystiene Level and Recurrent Abortion in Egyptian Women

Pulse Probiotic Superfood as Iron Status Improvement Agent in Active Women—A Review

Correlation of serum homocysteine levels in pregnancy related hypertensive disorders versus normotensive pregnancies

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